Photo of Sara A Courtneidge, Ph.D., D.Sc.

Sara A Courtneidge Ph.D., D.Sc.

  • (503) 496-4750
    • Professor of Cell, Developmental and Cancer Biology School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Sara A. Courtneidge was born in the UK, and received her B.Sc. from the University of Leeds and her Ph.D. from the National Institute for Medical Research, London. Following postdoctoral study at the University of California, San Francisco, and an independent position at the National Institute for Medical Research, she joined the European Molecular Biology Laboratory in Heidelberg, Germany in 1985, where she rose to the position of Senior Scientist. Changing course in 1994, Dr. Courtneidge joined SUGEN Inc., where as Chief Scientist she guided novel kinase discovery and validation efforts in oncology. From 2001-2005 she was Distinguished Scientific Investigator at the Van Andel Research Institute in Grand Rapids, Michigan, and from 2005-2014 she served as Professor and Director of the Tumor Microenvironment and Metastasis Program, and Director of Academic Affairs, at the Sanford|Burnham Medical Research Institute. She joined OHSU in 2014, where she is an Associate Director of Translational Sciences for the Knight Cancer Institute, a Professor in the Department of Cell, Developmental & Cancer Biology, and a member of the Center for Spatial Systems Biomedicine. Dr. Courtneidge’s laboratory has studied the Src family of protein tyrosine kinases for a number of years, and has contributed to the understanding of Src transformation, regulation, substrate selection and function. Currently, her research on Src and it substrates focuses on cancer invasion and metastasis, with particular emphasis on the role of membrane structures called podosomes or invadopodia. She also retains an interest in translational research, with the goal of defining novel therapeutic points of intervention for cancer treatment. Dr. Courtneidge’s contributions to cancer research have been recognized with numerous honors, including election to the European Molecular Biology Organization, the Jubilee Lecture and Harden Medal of the British Biochemical Society, the Feodor Lynen Lecture and Lynen Medal, an honorary doctorate from the University of Leeds, and, most recently, the 2015 AACR-WICR Charlotte Friend Memorial Lectureship.

Publications

  • "ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions." Journal of Cell Science  In: , Vol. 130, No. 12, 15.06.2017, p. 2036-2048.
  • "Invadosomes are coming : New insights into function and disease relevance." FEBS Journal In: , 2017.
  • "The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma." Oncotarget In: , Vol. 7, No. 48, 2016, p. 78473-78486.
  • "The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo." PLoS One In: , Vol. 10, No. 3, e0121003, 31.03.2015.
  • "Genetic disruption of the Sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of Tks5." PLoS One  In: , Vol. 9, No. 9, e107674, 26.09.2014.
  • "Regulation of invadopodia by the tumor microenvironment." Cell Adhesion and Migration In: , Vol. 8, No. 3, 01.05.2014, p. 226-235.
  • "Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells." Prostate In: , Vol. 74, No. 2, 02.2014, p. 134-148.
  • "Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis." Cell Reports In: , Vol. 8, No. 5, 2014, p. 1558-1570.
  • "Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia." Journal of Cell Biology In: , Vol. 201, No. 2, 15.04.2013, p. 279-292.
  • "Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma." Science Translational Medicine In: , Vol. 4, No. 127, 127ra36, 28.03.2012.
  • "Fer kinase regulates cell migration through α-dystroglycan glycosylation." Molecular Biology of the Cell  In: , Vol. 23, No. 5, 01.03.2012, p. 771-780.
  • "Cell migration and invasion in human disease : The Tks adaptor proteins." Biochemical Society Transactions In: , Vol. 40, No. 1, 02.2012, p. 129-132.
  • "Redox signaling at invasive microdomains in cancer cells." Free Radical Biology and Medicine In: , Vol. 52, No. 2, 15.01.2012, p. 247-256.
  • "A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion." Science Signaling In: , Vol. 4, No. 183, ra49, 26.07.2011.
  • "The 'ins' and 'outs' of podosomes and invadopodia : Characteristics, formation and function." Nature Reviews Molecular Cell Biology In: , Vol. 12, No. 7, 06.2011, p. 413-426.
  • "Podosomal proteins as causes of human syndromes : A role in craniofacial development?" Genesis In: , Vol. 49, No. 4, 04.2011, p. 209-221.
  • "A Src-Tks5 pathway is required for neural crest cell migration during embryonic development." PLoS One In: , Vol. 6, No. 7, e22499, 2011.
  • "MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro." Journal of Cell Biology In: , Vol. 189, No. 1, 05.04.2010, p. 13-22.
  • "Disruption of the Podosome Adaptor Protein TKS4 (SH3PXD2B) Causes the Skeletal Dysplasia, Eye, and Cardiac Abnormalities of Frank-Ter Haar Syndrome." American Journal of Human Genetics  In: , Vol. 86, No. 2, 12.02.2010, p. 254-261.
  • "Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation." Science Signaling In: , Vol. 2, No. 88, 15.09.2009.
  • "Novel p47-related organizers regulate localized NADPH oxidase 1 (Nox1) activity." Science Signaling In: , Vol. 2, No. 88, 15.09.2009.
  • "Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation." Experimental Cell Research  In: , Vol. 315, No. 15, 10.09.2009, p. 2581-2592.
  • "Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation." Journal of Cell Science  In: , Vol. 122, No. 15, 01.08.2009, p. 2727-2740.
  • "The novel adaptor protein tks4 (SH3PXD2B) is required for functional podosome formation." Molecular Biology of the Cell In: , Vol. 20, No. 5, 01.03.2009, p. 1302-1311.
  • "The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice : Correlates with human disease." Cell Death and Differentiation In: , Vol. 16, No. 12, 2009, p. 1590-1598.
  • "The Translational Research Working Group Developmental Pathway for anticancer agents (drugs or biologics)." Clinical Cancer Research In: , Vol. 14, No. 18, 15.09.2008, p. 5685-5691.
  • "A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo." European Journal of Cell Biology In: , Vol. 87, No. 8-9, 04.09.2008, p. 555-567.
  • "The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1." Molecular Biology of the Cell In: , Vol. 19, No. 7, 07.2008, p. 2984-2994.
  • "Assembly and biological role of podosomes and invadopodia." Current Opinion in Cell Biology  In: , Vol. 20, No. 2, 04.2008, p. 235-241.
  • "Non-receptor protein tyrosine kinases."  Protein Phosphorylation. wiley, 2007. p. 237-264.

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