Photo of Robert F. Klein, M.D.

Robert F. Klein M.D.

    • Professor of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition School of Medicine
    • Graduate Programs in Human Nutrition School of Medicine

Dr. Klein received his medical degree in 1980 from the University of California-San Francisco. He completed his residency at New York Hospital-Columbia University Medical Center, and underwent his fellowship in diabetes, endocrinology and metabolism at UCSF. Dr. Klein became board certified in internal medicine in 1983, and in endocrinology in 1987.

  • Residency:

    • New York Hospital, Columbia University Medical Center
  • Fellowship:

    • Diabetes/endocrinology/metabolism-University of California, San Francisco

Memberships and associations

  • Internal medicine, 1983

Publications

  • "Expanding the net : The re-evaluation of the multidimensional nomogram calculating the upper limit of normal PTH (maxPTH) in the setting of secondary hyperparathyroidism and the development of the MultIdimensional Predictive hyperparaTHyroid model (Mi-PTH)." Surgery (United States)  In: , Vol. 159, No. 1, 01.01.2016, p. 226-239.
  • "Neonatal estrogen exposure results in biphasic age-dependent effects on the skeletal development of male mice." Endocrinology In: , Vol. 156, No. 1, 01.01.2015, p. 193-202.
  • "Distinct actions of Akt1 on skeletal architecture and function." PLoS One  In: , Vol. 9, No. 3, e93040, 24.03.2014.
  • "Hypocalcemia."   Endocrine Emergencies: Recognition and Treatment. Humana Press Inc., 2014. p. 149-160.
  • "Hypercalcemia."   Endocrine Emergencies: Recognition and Treatment. Humana Press Inc., 2014. p. 161-174.
  • "The bone disease associated with factor VIII deficiency in mice is secondary to increased bone resorption." Haemophilia In: , Vol. 19, No. 6, 11.2013, p. 908-912.
  • "Sex and the single nucleotide polymorphism : Exploring the genetic causes of skeletal sex differences." Journal of Bone and Mineral Research In: , Vol. 27, No. 10, 10.2012, p. 2047-2050.
  • "Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system." PLoS One In: , Vol. 7, No. 7, e42183, 27.07.2012.
  • "Decreased bone density and bone strength in a mouse model of severe factor VIII deficiency." British Journal of Haematology In: , Vol. 158, No. 1, 07.2012, p. 140-143.
  • "Melanocortin-3 receptor regulates the normal fasting response." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 109, No. 23, 05.06.2012.
  • "Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition." Journal of Bone and Mineral Research In: , Vol. 27, No. 6, 06.2012, p. 1345-1356.
  • "Rare coding variants in ALPL are associated with low serum alkaline phosphatase and low bone mineral density." Journal of Bone and Mineral Research In: , Vol. 27, No. 1, 01.2012, p. 93-103.
  • "Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones (The Journal of Biological Chemistry (2010) 285, (17253-17262) DOI : 10.1074/jbc.A110.102228)." Journal of Biological Chemistry  In: , Vol. 285, No. 26, 25.06.2010, p. 20421.
  • "Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones." Journal of Biological Chemistry  In: , Vol. 285, No. 22, 28.05.2010, p. 17253-17262.
  • "The Genetics of Peak Bone Mass."   Osteoporosis in Men. Elsevier Inc., 2010. p. 149-163.
  • "A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 106, No. 33, 18.08.2009, p. 14034-14039.
  • "Nonpharmacological approaches to improve bone health and reduce osteoporosis." Current Opinion in Rheumatology In: , Vol. 20, No. 2, 03.2008, p. 213-217.
  • "Genetics of osteoporosis - Utility of mouse models." Journal of Musculoskeletal Neuronal Interactions In: , Vol. 8, No. 4, 2008, p. 287-290.
  • "Osteoporosis in Men : Epidemiology, Pathophysiology, and Clinical Characterization."  Osteoporosis, Two-Volume Set. Elsevier Inc., 2008. p. 1055-1094.
  • "Perioperative parathyroid hormone levels in thyroid surgery." Laryngoscope In: , Vol. 116, No. 4, 04.2006, p. 518-521.
  • "Human ALOX12, but not ALOX15, is associated with BMD in white men and women." Journal of Bone and Mineral Research In: , Vol. 21, No. 4, 04.2006, p. 556-564.
  • "Murine models of osteoporosis."  Computational Genetics and Genomics: Tools for Understanding Disease. Humana Press Inc., 2005. p. 147-175.
  • "Regulation of Bone Mass in Mice by the Lipoxygenase Gene Alox15." Science In: , Vol. 303, No. 5655, 09.01.2004, p. 229-232.
  • "Mapping quantitative trait loci that influence femoral cross-sectional area in mice." Journal of Bone and Mineral Research In: , Vol. 17, No. 10, 01.10.2002, p. 1752-1760.
  • "Genetic regulation of bone mineral density in mice." Journal of Musculoskeletal Neuronal Interactions In: , Vol. 2, No. 3, 2002, p. 232-236.
  • "In silico mapping of complex disease-related traits in mice." Science In: , Vol. 292, No. 5523, 08.06.2001, p. 1915-1918.
  • "Phenotypic characterization of mice bred for high and low peak bone mass." Journal of Bone and Mineral Research In: , Vol. 16, No. 1, 2001, p. 63-71.
  • "Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice." Journal of Bone and Mineral Research In: , Vol. 16, No. 11, 2001, p. 1953-1961.
  • "Gender specificity in the genetic determinants of peak bone mass." Journal of Bone and Mineral Research In: , Vol. 16, No. 11, 2001, p. 1962-1971.
  • "Quantitative trait loci affecting peak bone mineral density in mice." Journal of Bone and Mineral Research In: , Vol. 13, No. 11, 11.1998, p. 1648-1656.

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