Photo of Richard Maurer, Ph.D.

Richard Maurer Ph.D.

  • 5034947524
    • Professor of Cell, Developmental and Cancer Biology School of Medicine
To adapt to the environment, cells must respond to extracellular events with selective changes in gene expression. Receptor-regulated protein kinases are an important signaling mechanism which permits events at the cell membrane to alter the transcription of specific genes. This laboratory seeks to understand the intracellular signaling pathways which carry the message to the nucleus well as the nuclear events which mediate changes in pituitary hormone gene expression. Some of our studies examine the regulation of luteinizing hormone and follicle stimulating hormone gene expression. These pituitary hormones are essential for normal reproductive function. We also study the regulation of prolactin, a pituitary hormone which is essential for lactation. The studies seek to identify the signal transduction pathways, specific DNA elements and transcription factors which are required for the tissue-specific, regulated expression of these pituitary hormone genes. Several recent studies have focused on the role of LIM homeodomain transcription factors and their co-activators in regulating pituitary hormone promoter activity.

Memberships and associations

  • Cell &Developmental Biology Program in Molecular &Cellular Biosciences

Publications

  • "Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17." Experimental Cell Research In: , Vol. 319, No. 14, 15.08.2013, p. 2275-2281.
  • "Regulation of LIM-domain-binding 1 protein expression by ubiquitination of Lys134 ." Biochemical Journal In: , Vol. 429, No. 1, 01.07.2010, p. 127-136.
  • "Transcription intermediary factor 1γ decreases protein expression of the transcriptional cofactor, LIM-domain-binding 1." Biochemical and Biophysical Research Communications In: , Vol. 396, No. 3, 04.06.2010, p. 674-678.
  • "Generation of mice with a conditional allele for Ift172." Transgenic Research In: , Vol. 19, No. 1, 01.2010, p. 121-126.
  • "Expression of the synaptotagmin I gene is enhanced by binding of the pituitary-specific transcription factor, POU1F1." Molecular Endocrinology In: , Vol. 23, No. 10, 2009, p. 1563-1571.
  • "The pituitary-specific transcription factor, Pit-1, can direct changes in the chromatin structure of the prolactin promoter." Molecular Endocrinology In: , Vol. 19, No. 1, 01.2005, p. 138-147.
  • "Gonadotropin-releasing hormone-induced stimulation of the rat secretogranin II promoter involves activation of CREB." Molecular and Cellular Endocrinology  In: , Vol. 199, No. 1-2, 31.01.2003, p. 29-36.
  • "A Point Mutation in the LIM Domain of Lhx3 Reduces Activation of the Glycoprotein Hormone α-Subunit Promoter." Journal of Biological Chemistry In: , Vol. 276, No. 22, 01.06.2001, p. 19020-19026.
  • "Analysis of the role of the mitogen-activated protein kinase in mediating cyclic-adenosine 3′,5′-Monophosphate effects on prolactin promoter activity." Molecular Endocrinology In: , Vol. 15, No. 4, 2001, p. 614-624.
  • "Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors." Journal of Biological Chemistry In: , Vol. 275, No. 18, 05.05.2000, p. 13336-13342.
  • "Thyrotropin-releasing hormone stimulates phosphorylation of the epidermal growth factor receptor in GH3 pituitary cells." Molecular Endocrinology In: , Vol. 14, No. 9, 2000, p. 1328-1337.
  • "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone α-subunit gene expression." Journal of Biological Chemistry In: , Vol. 274, No. 51, 17.12.1999, p. 36159-36167.
  • "A role for the mitogen-activated protein kinase in mediating the ability of thyrotropin-releasing hormone to stimulate the prolactin promoter." Molecular Endocrinology In: , Vol. 13, No. 7, 1999, p. 1094-1104.
  • "Regulation of glyeoprotein hormone α-subunit gene expression." Recent Progress in Hormone Research In: , Vol. 54, 1999, p. 455-485.
  • "Characterization of DNA regions mediating the ability of Ca2+/calmodulin dependent protein kinase II to stimulate prolactin promoter activity." Molecular and Cellular Endocrinology In: , Vol. 132, No. 1-2, 1997, p. 109-116.
  • "Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV." Journal of Biological Chemistry In: , Vol. 271, No. 6, 09.02.1996, p. 3066-3073.
  • "In Vivo mutational analysis of the DNA binding domain of the tissue-specific transcription factor, Pit-1." Journal of Biological Chemistry In: , Vol. 270, No. 43, 27.10.1995, p. 25520-25525.
  • "An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation." Journal of Biological Chemistry In: , Vol. 270, No. 13, 1995, p. 7041-7044.
  • "A role for mitogen-activated protein kinase in mediating activation of the glycoprotein hormone α-subunit promoter by gonadotropin-releasing hormone." Molecular and Cellular Biology In: , Vol. 15, No. 7, 1995, p. 3531-3539.
  • "A composite Ets/Pit-1 binding site in the prolactin gene can mediate transcriptional responses to multiple signal transduction pathways." Journal of Biological Chemistry In: , Vol. 270, No. 36, 1995, p. 20930-20936.
  • "Thyrotropin releasing hormone stimulates transient phosphorylation of the tissue-specific transcription factor, Pit-1." Journal of Biological Chemistry In: , Vol. 269, No. 46, 18.11.1994, p. 28662-28669.
  • "Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity." Genes and Development In: , Vol. 8, No. 21, 01.11.1994, p. 2527-2539.
  • "Pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3′,5′-monophosphate through a mechanism that does not require inducible phosphorylation of Pit-1." Molecular Endocrinology In: , Vol. 8, No. 11, 11.1994, p. 1559-1565.
  • "Activation of the glycoprotein hormone α-subunit promoter by a LIM-homeodomain transcription factor." Molecular and Cellular Biology In: , Vol. 14, No. 5, 05.1994, p. 2985-2993.
  • "Involvement of a cAMP-responsive DNA element in mediating TRH responsiveness of the human thyrotropin α-subunit gene." Molecular Endocrinology In: , Vol. 8, No. 4, 04.1994, p. 528-536.
  • "Multiple Pit-1-binding sites facilitate estrogen responsiveness of the prolactin gene." Molecular Endocrinology In: , Vol. 8, No. 12, 1994, p. 1742-1749.
  • "Involvement of a cAMP-responsive DNA element in mediating TRH responsiveness of the human thyrotropin α-subunit gene." Molecular Endocrinology In: , Vol. 8, No. 4, 1994, p. 528-536.
  • "Two different DNA elements mediate gonadotropin releasing hormone effects on expression of the glycoprotein hormone α-subunit gene." Journal of Biological Chemistry In: , Vol. 268, No. 6, 25.02.1993, p. 3903-3910.
  • "The FSH β-subunit promoter directs the expression of Herpes simplex virus type 1 thymidine kinase to the testis of transgenic mice." Molecular and Cellular Endocrinology In: , Vol. 96, No. 1-2, 1993, p. 25-36.
  • "Effect of the thermostable protein kinase inhibitor on intracellular localization of the catalytic subunit of cAMP-dependent protein kinase." Journal of Biological Chemistry In: , Vol. 267, No. 24, 25.08.1992, p. 16824-16828.

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