Richard Goodman is a senior scientist in the Vollum Institute. He also holds appointments as professor of Cell, Developmental and Cancer Biology and Biochemistry and Molecular Biology. After receiving his B.S. degree in Chemistry at the Massachusetts Institute of Technology, he entered the Medical Scientist Training Program at the University of Pennsylvania. He received his M.D. and Ph.D. degrees in 1976. Goodman trained in clinical medicine at Tufts-New England Medical Center from 1976 to 1978 and was an endocrinology fellow at New England Medical Center and Massachusetts General Hospital. He has been at the Vollum since 1990 and served as the Institute's director from 1990 until 2016.
Dr. Goodman's contributions include the characterization of the cAMP regulated enhancer (CRE), identification of the CREB coactivator, CBP, and one of the first genome-wide analyses of transcription factor binding sites in metazoan cells. He has trained 14 graduate students and 29 fellows, many of whom have gone on to have successful careers as independent investigators.
Areas of interest
- metabolic regulation of gene expression
- characterization of activity-regulated genes
- B.S., Massachusetts Institute of Technology, Cambridge Massachusetts 1970
- M.D., University of Pennsylvania, Philadelphia Pennsylvania 1976
- Ph.D., University of Pennsylvania, Philadelphia Pennsylvania 1976
Honors and awards
- National Academy of Sciences, elected member (2002)
- Institute of Medicine, elected member (2005)
- Scientific Review Board, Howard Hughes Medical Institute (2008-2011)
- Director of the Vollum Institute (1990-2016)
Cambronne XA, Stewart ML, Kim D, Jones-Brunette AM, Morgan RK, Farrens DL, Cohen MS, Goodman RH. (2016) Biosensor reveals multiple sources for mitochondrial NAD+. Science 352:1474-1477.
Cambronne XA, Shen R, Auer PL, and Goodman RH. (2012) Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach. Proc. Natl. Acad. Sci. USA 109:20473-20478.
Magill ST, Cambronne XA, Luikart BW, Lioy DT, Leighton BH, Westbrook GL, Mandel G, and Goodman RH. (2010) MicroRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc. Natl. Acad. Sci. USA. 107:20382-20387
Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM, McWeeney S, Dunn JJ, Mandel G, and Goodman RH. (2004) Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 119:1041-1054.