Photo of Richard Goodman, M.D., Ph.D.

Richard Goodman M.D., Ph.D.

  •      (503) 494-5409
    • Professor Vollum Institute
    • Senior Scientist Vollum Institute
    • Biochemistry and Molecular Biology Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Richard Goodman is a senior scientist in the Vollum Institute. He also holds appointments as professor of Cell, Developmental and Cancer Biology and Biochemistry and Molecular Biology. After receiving his B.S. degree in Chemistry at the Massachusetts Institute of Technology, he entered the Medical Scientist Training Program at the University of Pennsylvania. He received his M.D. and Ph.D. degrees in 1976. Goodman trained in clinical medicine at Tufts-New England Medical Center from 1976 to 1978 and was an endocrinology fellow at New England Medical Center and Massachusetts General Hospital. He has been at the Vollum since 1990 and served as the Institute's director from 1990 until 2016.

Dr. Goodman's contributions include the characterization of the cAMP regulated enhancer (CRE), identification of the CREB coactivator, CBP, and one of the first genome-wide analyses of transcription factor binding sites in metazoan cells. He has trained 14 graduate students and 29 fellows, many of whom have gone on to have successful careers as independent investigators.

Areas of interest

  • metabolic regulation of gene expression
  • characterization of activity-regulated genes

Education

  • B.S., Massachusetts Institute of Technology, Cambridge Massachusetts 1970
  • M.D., University of Pennsylvania, Philadelphia Pennsylvania 1976
  • Ph.D., University of Pennsylvania, Philadelphia Pennsylvania 1976

Honors and awards

  • National Academy of Sciences, elected member (2002)
  • Institute of Medicine, elected member (2005)
  • Scientific Review Board, Howard Hughes Medical Institute (2008-2011)
  • Director of the Vollum Institute (1990-2016)

Publications

  • "miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock." Cell Reports In: , Vol. 19, No. 3, 18.04.2017, p. 505-520.
  • "Biosensor reveals multiple sources for mitochondrial NAD+." Science In: , Vol. 352, No. 6292, 17.06.2016, p. 1474-1477.
  • "Cell-specific Profiling of Nascent Proteomes Using Orthogonal Enzyme-mediated Puromycin Incorporation." ACS Chemical Biology In: , Vol. 11, No. 6, 17.06.2016, p. 1532-1536.
  • "Transcriptional Profiling of Newly Generated Dentate Granule Cells Using TU Tagging Reveals Pattern Shifts in Gene Expression during Circuit Integration." eNeuro In: , Vol. 3, No. 1, 01.01.2016.
  • "Erratum : MIR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3 (Nature Communications (2015) 6 (7718) DOI:10.1038/ncomms8718)." Nature Communications  In: , Vol. 6, 8227, 21.08.2015.
  • "MiR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3." Nature Communications  In: , Vol. 6, 7718, 27.07.2015.
  • "Memory formation and retention are affected in adult miR-132/212 knockout mice." Behavioural Brain Research In: , Vol. 287, 01.07.2015, p. 15-26.
  • "Retraction for Zhang et al., Metabolic regulation of SIRT1 transcription via a HIC1 : CtBP corepressor complex." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 112, No. 7, 17.02.2015, p. E819.
  • "Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns." Neuron In: , Vol. 81, No. 6, 19.03.2014, p. 1255-1262.
  • "MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 110, No. 44, 29.10.2013, p. 17898-17903.
  • "Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 109, No. 50, 11.12.2012, p. 20473-20478.
  • "Regulation of microRNA-375 by cAMP in pancreatic-βcells." Molecular Endocrinology In: , Vol. 26, No. 6, 06.2012, p. 989-999.
  • "Corrigendum to "An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling" [YMCNE (2010) 146-156]." Molecular and Cellular Neuroscience In: , Vol. 49, No. 2, 02.2012, p. 250.
  • "MicroRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 107, No. 47, 23.11.2010, p. 20382-20387.
  • "Affinity purification of microRNA-133a with the cardiac transcription factor, Hand2." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 107, No. 45, 09.11.2010, p. 19231-19236.
  • "MicroRNA pathways in neural development and plasticity." Current Opinion in Neurobiology In: , Vol. 20, No. 4, 08.2010, p. 457-465.
  • "An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling." Molecular and Cellular Neuroscience In: , Vol. 43, No. 1, 01.2010, p. 146-156.
  • "A β-catenin/TCF-coordinated chromatin loop at MYC integrates 5′ and 3′ Wnt responsive enhancers." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 107, No. 1, 2010, p. 145-150.
  • "A genome-wide screen for β-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression." Molecular and Cellular Biology In: , Vol. 28, No. 24, 12.2008, p. 7368-7379.
  • "An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 105, No. 26, 01.07.2008, p. 9093-9098.
  • "Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA." Nature Neuroscience In: , Vol. 10, No. 12, 12.2007, p. 1513-1514.
  • "Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy." Journal of Biological Chemistry In: , Vol. 282, No. 44, 02.11.2007, p. 32084-32092.
  • "A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions." Journal of Neuroscience  In: , Vol. 27, No. 25, 20.06.2007, p. 6729-6739.
  • "Serial analysis of chromatin occupancy identifies β-catenin target genes in colorectal carcinoma cells." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 104, No. 9, 27.02.2007, p. 3324-3329.
  • "Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation." Neoplasia In: , Vol. 9, No. 2, 02.2007, p. 101-107.
  • "Metabolic regulation of SIRT1 transcription via a HIC1 : CtBP corepressor complex." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 104, No. 3, 16.01.2007, p. 829-833.
  • "An antisense transcript induced by Wnt/β-catenin signaling decreases E2F4." Journal of Biological Chemistry In: , Vol. 282, No. 2, 12.01.2007, p. 871-878.
  • "Redox sensor CtBP mediates hypoxia-induced tumor cell migration." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 103, No. 24, 13.06.2006, p. 9029-9033.
  • "Erratum : A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis (Proceedings of the National Academy of Sciences of the United States of America (November 8, 2005) 102, 45 (16426-16431) DOI: 10.1073/pnas.0508448102)." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 103, No. 3, 17.01.2006, p. 825.
  • "Epigenetic mechanisms and gene networks in the nervous system." Journal of Neuroscience In: , Vol. 25, No. 45, 09.11.2005, p. 10379-10389.

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