Photo of Philip J. S. Stork, M.D.

Philip J. S. Stork M.D.

  •      (503) 494-5494
    • Professor Vollum Institute
    • Senior Scientist Vollum Institute
    • Cancer Biology Graduate Program School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • OHSU Knight Cancer Institute School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Philip Stork earned his M.D. at Columbia University in 1984 and went on to a residency in Pathology at Harvard Medical School and a fellowship at Tufts-New England Medical Center. He became an assistant professor in the Department of Pathology at Tufts in 1988. Stork was appointed as an assistant scientist at the Vollum Institute in 1990, was promoted to scientist in 1997 and senior scientist in 2005. He holds a joint appointment in the Department of Cell, Developmental and Cancer Biology in OHSU's School of Medicine.

Dr. Stork and his colleagues use molecular and biochemical approaches to understand how hormones and growth factors convey signals from the outside of a cell to the nucleus to induce cellular responses. Over the past few years, the Stork laboratory has tried to understand a fundamental question in the field of signal transduction: how can qualitative changes in the magnitude and duration of a single signaling cascade lead to qualitative changes in the cellular response?

Areas of interest

  • small G proteins
  • MAP kinase
  • B-Raf

Education

  • M.S., Stanford University, Stanford California 1978
  • B.S., Harvard University, Cambridge Massachusetts 1977
  • M.D., Columbia University, New York New York 1984

Memberships and associations

  • Editorial Board, Molecular Cell Biology, 2008-2020

Publications

  • "Phosphorylation of the C-Raf N region promotes Raf dimerization." Molecular and Cellular Biology In: , Vol. 37, No. 19, e00132-17, 01.10.2017.
  • "Analysis of K-Ras interactions by biotin ligase tagging." Cancer Genomics and Proteomics  In: , Vol. 14, No. 4, 01.07.2017, p. 225-239.
  • "Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates." Cell Reports  In: , Vol. 19, No. 3, 18.04.2017, p. 617-629.
  • "Phosphorylation of Rap1 by cAMP-dependent protein kinase (PKA) creates a binding site for KSR to sustain ERK activation by cAMP." Journal of Biological Chemistry In: , Vol. 292, No. 4, 27.01.2017, p. 1449-1461.
  • "Protein kinase A-independent Ras protein activation cooperates with Rap1 protein to mediate activation of the extracellular signal-regulated kinases (ERK) by cAMP." Journal of Biological Chemistry  In: , Vol. 291, No. 41, 07.10.2016, p. 21584-21595.
  • "ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells." Cellular Signalling  In: , Vol. 28, No. 3, 01.03.2016, p. 177-189.
  • "Unexpected maturation of PI3K and MAPK-ERK signaling in fetal ovine cardiomyocytes." American Journal of Physiology - Heart and Circulatory Physiology In: , Vol. 307, No. 8, 15.10.2014, p. H1216-H1225.
  • "Protein kinase a-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration." Journal of Biological Chemistry  In: , Vol. 288, No. 39, 27.09.2013, p. 27712-27723.
  • "Ras-mutant cancer cells display B-Raf binding to ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase a phosphorylation." Journal of Biological Chemistry  In: , Vol. 288, No. 38, 20.09.2013, p. 27646-27657.
  • "Allosteric activation of functionally asymmetric RAF kinase dimers." Cell In: , Vol. 154, No. 5, 29.08.2013, p. 1036-1046.
  • "B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells." International Immunology  In: , Vol. 25, No. 4, 04.2013, p. 259-269.
  • "N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 110, No. 1, 02.01.2013, p. 312-317.
  • "Mid-gestation ovine cardiomyocytes are vulnerable to mitotic suppression by thyroid hormone." Reproductive Sciences In: , Vol. 19, No. 6, 06.2012, p. 642-649.
  • "Thyroid hormone drives fetal cardiomyocyte maturation." FASEB Journal In: , Vol. 26, No. 1, 01.2012, p. 397-408.
  • "The interaction of Epac1 and ran promotes Rap1 activation at the nuclear envelope." Molecular and Cellular Biology  In: , Vol. 30, No. 16, 08.2010, p. 3956-3969.
  • "ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells." Journal of Biological Chemistry  In: , Vol. 284, No. 35, 28.08.2009, p. 23564-23573.
  • "CAMP signaling for ERK activation in neuronal cells." Folia Pharmacologica Japonica  In: , Vol. 133, No. 2, 2009, p. 63-68.
  • "Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2." Molecular and Cellular Biology  In: , Vol. 28, No. 23, 12.2008, p. 7109-7125.
  • "Putting on the RITz." Science's STKE : signal transduction knowledge environment  In: , Vol. 2007, No. 416, 11.12.2007.
  • "Rap1 : Selective activator of β2 integrins?" Blood  In: , Vol. 110, No. 10, 15.11.2007, p. 3496-3497.
  • "The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells." Journal of Neurochemistry  In: , Vol. 101, No. 2, 04.2007, p. 470-482.
  • "Sustained activation of extracellular signal-regulated kinase by nerve growth factor regulates c-fos protein stabilization and transactivation in PC12 cells." Journal of Neurochemistry  In: , Vol. 99, No. 6, 12.2006, p. 1480-1493.
  • "Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation." Molecular and Cellular Biology  In: , Vol. 26, No. 6, 03.2006, p. 2130-2145.
  • "Multiple roles of Rap1 in hematopoietic cells : Complementary versus antagonistic functions." Blood In: , Vol. 106, No. 9, 11.2005, p. 2952-2961.
  • "Unraveling the mysteries of B-Raf : The clot thickens!" Blood  In: , Vol. 106, No. 3, 01.08.2005, p. 775-776.
  • "Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4." Molecular and Cellular Biology  In: , Vol. 25, No. 10, 05.2005, p. 4117-4128.
  • "Directing NGF's actions : It's a rap." Nature Cell Biology In: , Vol. 7, No. 4, 04.2005, p. 338-339.
  • "Ras-independent activation of ERK signaling via the Torso receptor tyrosine kinase is mediated by Rap1." Current Biology  In: , Vol. 15, No. 4, 22.02.2005, p. 366-370.
  • "PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells." Journal of Cell Science  In: , Vol. 117, No. 25, 01.12.2004, p. 6085-6094.
  • "Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes." American Journal of Physiology - Regulatory Integrative and Comparative Physiology In: , Vol. 285, No. 6 54-6, 12.2003.

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