Photo of Paul T. Spellman, Ph.D.

Paul T. Spellman Ph.D.

    • Professor of Molecular and Medical Genetics School of Medicine
    • Co-Director, CEDAR OHSU Knight Cancer Institute School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Paul Spellman is a professor in the Department of Molecular and Medical Genetics in the OHSU School of Medicine and co-leader of the Quantitative Oncology Program in the OHSU Knight Cancer Institute. He uses genetic and genomic approaches to understand the processes by which cancer develops, monitor disease, and to identify therapeutic strategies. He focuses on using population genetics to help determine who is at risk for cancer, how to computationally analyze genomic data to identify early changes in cancers, and how to accurately screen different populations for the disease. He also works to inform the public about the ways that genetics shape cancer risk. Spellman received his Ph.D. in genetics from Stanford University.

Memberships and associations

  • OHSU Center for Spatial Systems Biomedicine

Publications

  • "Correction : Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer (PLoS ONE (2015) 10:7 (e0133219) DOI: 10.1371/journal.pone.0133219)." PLoS ONE In: , Vol. 12, No. 10, e0186551, 01.10.2017.
  • "Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma." Cancer Cell In: , Vol. 32, No. 2, 14.08.2017, p. 185-203.e13.
  • "Erratum to : "Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer", [Breast Cancer Research, 19, (2017) (17)] DOI: 10.1186/s13058-017-0809-6." Breast Cancer Research In: , Vol. 19, No. 1, 17, 09.02.2017.
  • "Circulating-tumor DNA as an early detection and diagnostic tool." Current Opinion in Genetics and Development  In: , Vol. 42, 01.02.2017, p. 14-21.
  • "Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling." Cell Systems In: , Vol. 4, No. 1, 25.01.2017, p. 73-83.e10.
  • "ΔN-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival." Biochemical and Biophysical Research Communications In: , Vol. 482, No. 4, 22.01.2017, p. 1271-1277.
  • "FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 113, No. 43, 25.10.2016, p. E6600-E6609.
  • "Identification of shared TCR sequences from T cells in human breast cancer Using emulsion RT-PCR." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 113, No. 29, 19.07.2016, p. 8272-8277.
  • "Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer." Breast Cancer Research In: , Vol. 18, No. 1, 70, 01.07.2016.
  • "Patient-specific factors influence somatic variation patterns in von Hippel-Lindau disease renal tumours." Nature Communications In: , Vol. 7, 11588, 13.05.2016.
  • "Inferring causal molecular networks : Empirical assessment through a community-based effort." Nature Methods  In: , Vol. 13, No. 4, 30.03.2016, p. 310-318.
  • "ARTIK-52 induces replication-dependent DNA damage and p53 activation exclusively in cells of prostate and breast cancer origin." Cell Cycle  In: , Vol. 15, No. 3, 01.02.2016, p. 455-470.
  • "Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma." New England Journal of Medicine  In: , Vol. 374, No. 2, 14.01.2016, p. 135-145.
  • "Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation." BMC Genomics  In: , Vol. 16, No. 13, S1, 16.12.2015.
  • "A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing." Nature Communications In: , Vol. 6, 10001, 09.12.2015.
  • "Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 112, No. 35, 01.09.2015, p. 10995-11000.
  • "Exome sequencing of cell-free DNA from metastatic cancer patients identifies clinically actionable mutations distinct from primary disease." PLoS One In: , Vol. 10, No. 8, e0136407, 28.08.2015.
  • "Predictive sparse morphometric context for classification of histology sections."   Proceedings - International Symposium on Biomedical Imaging. Vol. 2015-July IEEE Computer Society, 2015. p. 1004-1007 7164040.
  • "Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer." PLoS One  In: , Vol. 10, No. 7, e0133219, 16.07.2015.
  • "Erratum : Functionally defined therapeutic targets in diffuse intrinsic pontine glioma(Nature Medicine (2015) 21 (555-559) DOI: 10.1038/nm.3855)." Nature Medicine  In: , Vol. 21, No. 7, 07.07.2015, p. 827.
  • "TRAIL-based high throughput screening reveals a link between TRAIL-mediated apoptosis and glutathione reductase, a key component of oxidative stress response." PLoS One  In: , Vol. 10, No. 6, e0129566, 15.06.2015.
  • "Erratum to Modeling precision treatment of breast cancer [Genome Biology, 14, (2013), R110]." Genome Biology In: , Vol. 16, No. 1, 95, 12.05.2015.
  • "Functionally defined therapeutic targets in diffuse intrinsic pontine glioma." Nature Medicine  In: , Vol. 21, No. 6, 04.05.2015, p. 555-559.
  • "Stacked Predictive Sparse Decomposition for Classification of Histology Sections." International Journal of Computer Vision  In: , Vol. 113, No. 1, 01.05.2015, p. 3-18.
  • "A humanized leucine zipper-TRAIL hybrid induces apoptosis of tumors both in vitro and in vivo." PLoS One In: , Vol. 10, No. 4, e0122980, 07.04.2015.
  • "Colon and ovarian translocations."  Chromosomal Translocations and Genome Rearrangements in Cancer. Springer International Publishing, 2015. p. 417-426.
  • "Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma." Oncotarget In: , Vol. 6, No. 42, 2015, p. 44675-44687.
  • "Association of somatic mutations of ADAMTS genes with chemotherapy sensitivity and survival in high-grade serous ovarian carcinoma." JAMA oncology  In: , Vol. 1, No. 4, 2015, p. 486-494.
  • "Transcription Restores DNA Repair to Heterochromatin, Determining Regional Mutation Rates in Cancer Genomes." Cell Reports In: , Vol. 9, No. 4, 20.11.2014, p. 1228-1234.
  • "Classification of histology sections via multispectral convolutional sparse coding."   Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition. IEEE Computer Society, 2014. p. 3081-3088 6909790.

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