Photo of Paul T. Spellman, Ph.D.

Paul T. Spellman Ph.D.

    • Professor of Molecular and Medical Genetics School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine

Memberships and associations

  • OHSU Center for Spatial Systems Biomedicine

Publications

  • "Erratum to : "Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer", [Breast Cancer Research, 19, (2017) (17)] DOI: 10.1186/s13058-017-0809-6." Breast Cancer Research In: , Vol. 19, No. 1, 17, 09.02.2017.
  • "Circulating-tumor DNA as an early detection and diagnostic tool." Current Opinion in Genetics and Development  In: , Vol. 42, 01.02.2017, p. 14-21.
  • "Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling." Cell Systems In: , Vol. 4, No. 1, 25.01.2017, p. 73-83.e10.
  • "ΔN-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival." Biochemical and Biophysical Research Communications In: , Vol. 482, No. 4, 22.01.2017, p. 1271-1277.
  • "FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 113, No. 43, 25.10.2016, p. E6600-E6609.
  • "Identification of shared TCR sequences from T cells in human breast cancer Using emulsion RT-PCR." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 113, No. 29, 19.07.2016, p. 8272-8277.
  • "Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer." Breast Cancer Research In: , Vol. 18, No. 1, 70, 01.07.2016.
  • "Patient-specific factors influence somatic variation patterns in von Hippel-Lindau disease renal tumours." Nature Communications In: , Vol. 7, 11588, 13.05.2016.
  • "Inferring causal molecular networks : Empirical assessment through a community-based effort." Nature Methods  In: , Vol. 13, No. 4, 30.03.2016, p. 310-318.
  • "ARTIK-52 induces replication-dependent DNA damage and p53 activation exclusively in cells of prostate and breast cancer origin." Cell Cycle  In: , Vol. 15, No. 3, 01.02.2016, p. 455-470.
  • "Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma." New England Journal of Medicine  In: , Vol. 374, No. 2, 14.01.2016, p. 135-145.
  • "Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation." BMC Genomics  In: , Vol. 16, No. 13, S1, 16.12.2015.
  • "A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing." Nature Communications In: , Vol. 6, 10001, 09.12.2015.
  • "Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 112, No. 35, 01.09.2015, p. 10995-11000.
  • "Exome sequencing of cell-free DNA from metastatic cancer patients identifies clinically actionable mutations distinct from primary disease." PLoS One In: , Vol. 10, No. 8, e0136407, 28.08.2015.
  • "Predictive sparse morphometric context for classification of histology sections."   Proceedings - International Symposium on Biomedical Imaging. Vol. 2015-July IEEE Computer Society, 2015. p. 1004-1007 7164040.
  • "Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer." PLoS One  In: , Vol. 10, No. 7, e0133219, 16.07.2015.
  • "Erratum : Functionally defined therapeutic targets in diffuse intrinsic pontine glioma(Nature Medicine (2015) 21 (555-559) DOI: 10.1038/nm.3855)." Nature Medicine  In: , Vol. 21, No. 7, 07.07.2015, p. 827.
  • "TRAIL-based high throughput screening reveals a link between TRAIL-mediated apoptosis and glutathione reductase, a key component of oxidative stress response." PLoS One  In: , Vol. 10, No. 6, e0129566, 15.06.2015.
  • "Erratum to Modeling precision treatment of breast cancer [Genome Biology, 14, (2013), R110]." Genome Biology In: , Vol. 16, No. 1, 95, 12.05.2015.
  • "Functionally defined therapeutic targets in diffuse intrinsic pontine glioma." Nature Medicine  In: , Vol. 21, No. 6, 04.05.2015, p. 555-559.
  • "Stacked Predictive Sparse Decomposition for Classification of Histology Sections." International Journal of Computer Vision  In: , Vol. 113, No. 1, 01.05.2015, p. 3-18.
  • "A humanized leucine zipper-TRAIL hybrid induces apoptosis of tumors both in vitro and in vivo." PLoS One In: , Vol. 10, No. 4, e0122980, 07.04.2015.
  • "Colon and ovarian translocations."  Chromosomal Translocations and Genome Rearrangements in Cancer. Springer International Publishing, 2015. p. 417-426.
  • "Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma." Oncotarget In: , Vol. 6, No. 42, 2015, p. 44675-44687.
  • "Association of somatic mutations of ADAMTS genes with chemotherapy sensitivity and survival in high-grade serous ovarian carcinoma." JAMA oncology  In: , Vol. 1, No. 4, 2015, p. 486-494.
  • "Transcription Restores DNA Repair to Heterochromatin, Determining Regional Mutation Rates in Cancer Genomes." Cell Reports In: , Vol. 9, No. 4, 20.11.2014, p. 1228-1234.
  • "Classification of histology sections via multispectral convolutional sparse coding."   Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition. IEEE Computer Society, 2014. p. 3081-3088 6909790.
  • "Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase." Breast Cancer Research  In: , Vol. 16, No. 5, 430, 11.09.2014.
  • "Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin." Cell In: , Vol. 158, No. 4, 14.08.2014, p. 929-944.

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