Photo of Owen J.T. McCarty, Ph.D.

Owen J.T. McCarty Ph.D.

  • (503) 418-9307

    Portland Campus

    • Professor of Biomedical Engineering School of Medicine
    • Interim Chair Biomedical Engineering School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Biomedical Engineering Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. McCarty received his Ph.D in Chemical & Biomolecular Engineering from Johns Hopkins University with dissertation work focused on the role of platelets in cancer metastasis and thrombosis. As a Wellcome Trust Postdoctoral Fellow, he continued his research in the area of thrombosis, examining the signaling pathways governing platelet cytoskeleton reorganization, at the Department of Pharmacology, Oxford University and Centre for Cardiovascular Sciences, University of Birmingham, UK.

Areas of interest

  • Dr. McCarty's research is focused on understanding the interplay between cell biology and fluid mechanics in the cardiovascular system. In particular, his research into the balance between hydrodynamic shear forces and chemical adhesive interactions has great relevance to underlying processes of cancer, cardiovascular disease, and inflammation.

Education

  • Ph.D., Johns Hopkins University 2002
  • B.S., State University of New York 1997

Publications

Selected publications

  • Verhoef JJF, Barendrecht AD, Nickel KF, de Maat S, Keene E, Labberton L, McCarty OJ, Schiffelers R, Heijnen HF, Hendrickx AP, Schellekens H, Fens MH, Renne T, Maas C. Polyphosphate nanoparticles on the platelet surface trigger contact system activation. Blood 2017;129(12):1707-1717. (with Editorial; Cover)

  • Mitrugno A, Sylman JL, Ngo AT, Pang J, Sears RC, Williams CD, McCarty OJ. Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: implications for the oncoprotein c-MYC. American Journal of Physiology: Cell Physiology 2017 Feb 1;312(2):C176-C189. (Selected as the AJP: Cell Image of the Week; Featured in AJP News)

  • Zilberman-Rudenko J, Sylman JL, Lakshmanan HH, McCarty OJ*, Maddala J*. Dynamics of blood flow and thrombus formation in a multi-bypass microfluidic ladder network. Cellular and Molecular Bioengineering 2017 Feb;10(1):16-29. *equally contributing senior authors (with Editorial)

  • Zilberman-Rudenko J, Itakura A, Maddala J, Baker-Groberg SM, Vetter R, Tucker EI, Gruber A, Gerdes C, McCarty OJ. Biorheology of platelet activation in the bloodstream distal to thrombus formation. Cellular and Molecular Bioengineering 2016 Dec;9(4):496-508.

Publications

  • "Ticagrelor breaks up the tumor-platelet party." Blood In: , Vol. 130, No. 10, 07.09.2017, p. 1177-1178.
  • "Utility and development of microfluidic platforms for platelet research." Platelets In: , Vol. 28, No. 5, 04.07.2017, p. 425-426.
  • "Utility of microfluidic devices to study the platelet–endothelium interface." Platelets In: , Vol. 28, No. 5, 04.07.2017, p. 449-456.
  • "Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo." Journal of Biological Chemistry In: , Vol. 292, No. 21, 26.05.2017, p. 8616-8629.
  • "Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y signaling with MRS2395." Platelets In: , 20.05.2017, p. 1-12.
  • "Ibrutinib-associated bleeding : pathogenesis, management and risk reduction strategies." Journal of Thrombosis and Haemostasis In: , Vol. 15, No. 5, 01.05.2017, p. 835-847.
  • "Assessment of roles for the rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function : A spatial systems approach." American Journal of Physiology - Cell Physiology In: , Vol. 312, No. 4, 07.04.2017, p. C527-C536.
  • "Polyphosphate nanoparticles on the platelet surface trigger contact system activation." Blood  In: , Vol. 129, No. 12, 23.03.2017, p. 1707-1717.
  • "Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation : Implications for the oncoprotein c-MYC." American Journal of Physiology - Cell Physiology  In: , Vol. 312, No. 2, 08.02.2017, p. C176-C189.
  • "Nucleic acids as cofactors for factor XI and prekallikrein activation : Different roles for high-molecular-weight kininogen." Thrombosis and Haemostasis  In: , Vol. 117, No. 4, 2017, p. 671-681.
  • "Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin." Annals of Biomedical Engineering  In: , 08.12.2016, p. 1-13.
  • "Dynamics of Blood Flow and Thrombus Formation in a Multi-Bypass Microfluidic Ladder Network." Cellular and Molecular Bioengineering  In: , 20.10.2016, p. 1-14.
  • "Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va." Blood In: , Vol. 128, No. 14, 06.10.2016, p. 1870-1878.
  • "Platelet-derived short-chain polyphosphates enhance the inactivation of tissue factor pathway inhibitor by activated coagulation factor XI." PLoS One  In: , Vol. 11, No. 10, e0165172, 01.10.2016.
  • "Colocalization of neutrophils, extracellular DNA and coagulation factors during NETosis : Development and utility of an immunofluorescence-based microscopy platform." Journal of Immunological Methods  In: , Vol. 435, 01.08.2016, p. 77-84.
  • "Thrombosis in cancer : Research priorities identified by a national cancer institute/national heart, lung, and blood institute strategic working group." Cancer Research In: , Vol. 76, No. 13, 01.07.2016, p. 3671-3675.
  • "Biorheology of Platelet Activation in the Bloodstream Distal to Thrombus Formation." Cellular and Molecular Bioengineering  In: , 25.05.2016, p. 1-13.
  • "The hemostatic role of factor XI." Thrombosis Research  In: , Vol. 141, 01.05.2016, p. S8-S11.
  • "Factor XI deficiency alters the cytokine response and activation of contact proteases during polymicrobial sepsis in mice." PLoS One  In: , Vol. 11, No. 4, e0152968, 01.04.2016.
  • "Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation." American Journal of Physiology - Cell Physiology In: , Vol. 310, No. 7, 01.04.2016, p. C568-C575.
  • "Coated platelets function in platelet-dependent fibrin formation via integrin αβ and transglutaminase factor XIII." Haematologica  In: , Vol. 101, No. 4, 31.03.2016, p. 427-436.
  • "Dimensional analysis and scaling relevant to flow models of thrombus formation : Communication from the SSC of the ISTH." Journal of Thrombosis and Haemostasis In: , Vol. 14, No. 3, 01.03.2016, p. 619-622.
  • "Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function." American Journal of Physiology - Cell Physiology  In: , Vol. 310, No. 5, 01.03.2016, p. C373-C380.
  • "Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow." Arteriosclerosis, Thrombosis, and Vascular Biology  In: , 14.01.2016.
  • "The prothrombotic activity of cancer cells in the circulation." Blood Reviews  In: , Vol. 30, No. 1, 01.01.2016, p. 11-19.
  • "Assessment of neonatal platelet adhesion, activation, and aggregation." Journal of Thrombosis and Haemostasis In: , 2016.
  • "Data detailing the platelet acetyl-lysine proteome." Data in Brief  In: , Vol. 5, 01.12.2015, p. 368-371.
  • "Lysine acetyltransfer supports platelet function." Journal of Thrombosis and Haemostasis  In: , Vol. 13, No. 10, 01.10.2015, p. 1908-1917.
  • "Effect of Ionizing Radiation on the Physical Biology of Head and Neck Squamous Cell Carcinoma Cells." Cellular and Molecular Bioengineering  In: , Vol. 8, No. 3, 21.09.2015, p. 517-525.
  • "Critical Behavior of Subcellular Density Organization During Neutrophil Activation and Migration." Cellular and Molecular Bioengineering  In: , Vol. 8, No. 4, 03.06.2015, p. 543-552.

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