Photo of Nabil J. Alkayed, M.D., Ph.D

Nabil J. Alkayed M.D., Ph.D

    • Professor of Anesthesiology and Perioperative Medicine School of Medicine
    • Neuroscience Graduate Program School of Medicine

Dr. Alkayed is Professor and Vice Chair for Research of Anesthesiology and PeriOperative Medicine (APOM) at Oregon Health & Science University (OHSU) and holds a joint appointment in Physiology and Pharmacology. He is Director of the newly formed Division of Cerebrovascular Research and Associate Director of the Research Center for Gender-Based Medicine at OHSU. In addition, Dr. Alkayed serves on the Program for Molecular and Cellular Biosciences (PMCB) and the Neuroscience Graduate Program (NGP) at OHSU.Dr. Alkayed is funded through two R01 grants from the National Institute of Neurological Disease and Stroke (NINDS) to study the role of sEH in ischemic brain injury and vascular dysfunction after stroke n postmenopausal females. In addition, he has a grant from the Oregon Alzheimer Disease Center to study the role of sEH in aging-related white matter lesions. Dr. Alkayed sits on the editorial boards of Stroke, The American Journal of Physiology–Heart and Circulation, and the Journal of Cerebral Blood Flow and Metabolism. He is a member of the American Heart Association Brain and Stroke Study Section and the National Institutes of Health Neural Oxidative Metabolism and Death Study Section. Dr. Alkayed grew up in Amman, Jordan. He earned his medical degree from Stavropol State Medical Academy in Russia and a PhD in physiology from the Medical College of Wisconsin in Milwaukee. After completing a postdoctoral research fellowship at Johns Hopkins University, Dr. Alkayed launched his academic career as Assistant Professor of Anesthesiology & Critical Care Medicine at The Johns Hopkins School of Medicine in 1998. He joined OHSU in 2003 as Associate Professor, was promoted to Professor in 2008, and to Vice Chair for Research in 2011.

Education

  • M.D., Stavropol State Medical Academy, Stavropol 1986
  • Ph.D., Medical College of Wisconsin, Milwaukee Wisconsin 1996
  • Fellowship:

    • Postdoctoral Fellowship in Cerebral Ischemia, Johns Hopkins University, Baltimore, MD, 1996-1998

Memberships and associations

  • American Physiological Society Society for NeuroscienceFellow of the American Heart Association Stroke CouncilInternational Soceity of Cerebral Blood Flow and MetabolismAssociation of University Anesthesiologists

Publications

  • "Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing." Journal of Vascular Surgery In: , Vol. 65, No. 2, 01.02.2017, p. 478-483.
  • "-FNDP for PET Imaging of Soluble Epoxide Hydrolase." Journal of Nuclear Medicine In: , Vol. 57, No. 11, 01.11.2016, p. 1817-1822.
  • "Vapor Pressures of Anesthetic Agents at Temperatures Below 0°C and a Novel Anesthetic Delivery Device." Anesthesia and Analgesia In: , 13.09.2016.
  • "Automated segmentation and enhancement of optical coherence tomography-acquired images of rodent brain." Journal of Neuroscience Methods In: , Vol. 270, 01.09.2016, p. 132-137.
  • "Partial MHC class II constructs as novel immunomodulatory therapy for stroke." Neurochemistry International  In: , 01.09.2016.
  • "Temporal changes in skeletal muscle capillary responses and endothelial-derived vasodilators in obesity-related insulin resistance." Diabetes In: , Vol. 65, No. 8, 01.08.2016, p. 2249-2257.
  • "High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 36, No. 7, 01.07.2016, p. 1257-1270.
  • "Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium." Experimental Neurology In: , Vol. 279, 01.05.2016, p. 75-85.
  • "Disrupting dimerization translocates soluble epoxide hydrolase to peroxisomes." PLoS One In: , Vol. 11, No. 5, e0152742, 01.05.2016.
  • "Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid." Prostaglandins and Other Lipid Mediators In: , 28.04.2016.
  • "Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma." EBioMedicine  In: , Vol. 3, 01.01.2016, p. 26-42.
  • "A novel mouse model of thromboembolic stroke." Journal of Neuroscience Methods In: , Vol. 256, 30.12.2015, p. 203-211.
  • "Partial MHC Constructs Treat Thromboembolic Ischemic Stroke Characterized by Early Immune Expansion." Translational Stroke Research  In: , 01.12.2015, p. 1-9.
  • "Peroxisomal translocation of soluble epoxide hydrolase protects against ischemic stroke injury." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 35, No. 9, 03.09.2015, p. 1416-1420.
  • "Ultrasound stimulates formation and release of vasoactive compounds in brain endothelial cells." American Journal of Physiology - Heart and Circulatory Physiology  In: , Vol. 309, No. 4, 18.08.2015, p. H583-H591.
  • "Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation after Subarachnoid Hemorrhage." Stroke In: , Vol. 46, No. 7, 04.07.2015, p. 1916-1922.
  • "Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment." Translational Stroke Research In: , Vol. 6, No. 5, 05.06.2015, p. 390-398.
  • "Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux." Biochemical and Biophysical Research Communications  In: , Vol. 458, No. 3, 13.03.2015, p. 632-638.
  • "Recombinant T-cell receptor ligand RTL1000 limits inflammation and decreases infarct size after experimental ischemic stroke in middle-aged mice." Neuroscience In: , Vol. 288, 02.03.2015, p. 112-119.
  • "Peroxisomal biogenesis in ischemic brain." Antioxidants and Redox Signaling In: , Vol. 22, No. 2, 10.01.2015, p. 109-120.
  • "Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant." Synthetic Communications  In: , Vol. 45, No. 1, 02.01.2015, p. 105-110.
  • "Protective Role of P450 Epoxyeicosanoids in Subarachnoid Hemorrhage." Neurocritical Care In: , Vol. 22, No. 2, 2015, p. 306-319.
  • "Soluble epoxide hydrolase gene deletion improves blood flow and reduces infarct size after cerebral ischemia in reproductively senescent female mice." Frontiers in Pharmacology In: , Vol. 6, No. JAN, 290, 2015.
  • "Hyperglycemia abolishes the protective effect of ischemic preconditioning in glomerular endothelial cells in vitro." Physiological Reports In: , Vol. 3, No. 3, e12346, 2015.
  • "Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume." American Journal of Physiology - Endocrinology and Metabolism In: , Vol. 307, No. 12, 15.12.2014, p. E1097-E1104.
  • "Genetic variation in soluble epoxide hydrolase : association with outcome after aneurysmal subarachnoid hemorrhage." Journal of Neurosurgery In: , Vol. 121, No. 6, 01.12.2014, p. 1359-1366.
  • "CaMKKβ-Dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation." Antioxidants and Redox Signaling  In: , Vol. 21, No. 12, 20.10.2014, p. 1741-1758.
  • "Role of soluble epoxide hydrolase in age-related vascular cognitive decline." Prostaglandins and Other Lipid Mediators In: , Vol. 113-115, 30.09.2014, p. 30-37.
  • "Estrogen-mediated renoprotection following cardiac arrest and cardiopulmonary resuscitation is robust to GPR30 gene deletion." PLoS One  In: , Vol. 9, No. 6, e99910, 12.06.2014.
  • "Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke." PLoS One In: , Vol. 9, No. 5, e97529, 13.05.2014.

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