Photo of Mushui Dai, M.D., Ph.D.

Mushui Dai M.D., Ph.D.

  • (503) 494-7719
    • Associate Professor of Molecular and Medical Genetics School of Medicine
    • Cancer Biology Graduate Program School of Medicine

Dr. Dai’s research focuses on the understanding of the biological function and molecular mechanisms of the p53 tumor suppression and c-Myc oncogenic pathways. Dr. Dai’s prior research has demonstrated that some ribosomal proteins play a critical role in regulating both the MDM2-p53 and c-Myc pathway in response to nucleolar stress. His findings help to understand how ribosomal biogenesis is tightly coordinated with cell cycle progression during normal homeostasis. Currently, Dr. Dai’s lab is investigating (1) the mechanism underlying the RP inhibition of the MDM2-p53 pathway; (2) the mechanism underlying the regulation of c-myc mRNA stability by L11; (3) the role of deubiquitination in controlling p53 protein stability and activity by in response to stress. Dr. Dai’s research would provide important information on how p53 tumor and c-Myc oncoprotein are tightly controlled in both physiological and stress conditions, thereby providing a possible means to manipulate p53 and c-Myc function in cancer cells.

Education

  • M.D., Anhui Medical University, 0 China 1988
  • Ph.D., Oregon Health & Science University, Portland Oregon 2005

Publications

  • "ΔN-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival." Biochemical and Biophysical Research Communications In: , Vol. 482, No. 4, 22.01.2017, p. 1271-1277.
  • "Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria." Oncotarget  In: , Vol. 8, No. 7, 2017, p. 11053-11062.
  • "p73 to the rescue : Role of RPL26." Oncotarget  In: , Vol. 8, No. 4, 2017, p. 5641-5642.
  • "Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop." Oncotarget  In: , Vol. 7, No. 13, 29.03.2016, p. 16217-16226.
  • "The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 112, No. 12, 24.03.2015, p. 3734-3739.
  • "Deubiquitinating c-Myc : USP36 steps up in the nucleolus." Cell Cycle  In: , Vol. 14, No. 24, 01.01.2015, p. 3786-3793.
  • "Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein." Journal of Virology  In: , Vol. 89, No. 6, 2015, p. 3038-3048.
  • "MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation." Oncotarget  In: , Vol. 6, No. 2, 2015, p. 1101-1114.
  • "Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF." Oncogene In: , 28.04.2014.
  • "Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and Stabilize p53 protein." Journal of Biological Chemistry  In: , Vol. 289, No. 8, 21.02.2014, p. 5097-5108.
  • "Growth inhibitory effects of large subunit ribosomal proteins in melanoma." Pigment Cell and Melanoma Research In: , Vol. 27, No. 5, 2014, p. 801-812.
  • "Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy." Current Pharmaceutical Design  In: , Vol. 19, No. 18, 2013, p. 3248-3262.
  • "HIF1α protein stability is increased by acetylation at lysine 709." Journal of Biological Chemistry In: , Vol. 287, No. 42, 12.10.2012, p. 35496-35505.
  • "Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF." Journal of Biological Chemistry  In: , Vol. 287, No. 21, 18.05.2012, p. 17120-17129.
  • "Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion." Journal of Biological Chemistry  In: , Vol. 287, No. 13, 23.03.2012, p. 10013-10020.
  • "Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1." EMBO Journal  In: , Vol. 31, No. 3, 01.02.2012, p. 576-592.
  • "Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress." Molecular and Cellular Biology  In: , Vol. 31, No. 19, 10.2011, p. 4007-4021.
  • "Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress." Journal of Biological Chemistry  In: , Vol. 286, No. 26, 01.07.2011, p. 22730-22741.
  • "Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression (Journal of Biological Chemistry (2005) 280, (12587-12594))." Journal of Biological Chemistry  In: , Vol. 285, No. 50, 10.12.2010, p. 39574.
  • "Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation." Journal of Biological Chemistry  In: , Vol. 285, No. 33, 13.08.2010, p. 25812-25821.
  • "Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression." Journal of Biological Chemistry  In: , Vol. 285, No. 17, 23.04.2010, p. 12587-12594.
  • "Erratum : Inhibition of c-Myc activity by ribosomal protein L11 (The EMBO Journal (2009) 28 (993) DOI: 10.1038/emboj.2009.70)." EMBO Journal  In: , Vol. 28, No. 7, 08.04.2009, p. 993.
  • "Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer." Journal of Cellular Biochemistry  In: , Vol. 105, No. 3, 15.10.2008, p. 670-677.
  • "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2." Molecular and Cellular Biology  In: , Vol. 28, No. 13, 07.2008, p. 4365-4376.
  • "Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11." Journal of Biological Chemistry  In: , Vol. 283, No. 18, 02.05.2008, p. 12387-12392.
  • "Feedback regulation of c-Myc by ribosomal protein L11." Cell Cycle  In: , Vol. 6, No. 22, 15.11.2007, p. 2735-2741.
  • "Inhibition of c-Myc activity by ribosomal protein L11." EMBO Journal  In: , Vol. 26, No. 14, 25.07.2007, p. 3332-3345.
  • "5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction." Journal of Biological Chemistry  In: , Vol. 282, No. 11, 16.03.2007, p. 8052-8059.
  • "Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest." Journal of Biological Chemistry  In: , Vol. 281, No. 40, 06.10.2006, p. 30036-30045.
  • "Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism." Journal of Biological Chemistry  In: , Vol. 281, No. 34, 25.08.2006, p. 24304-24313.

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