Photo of Mihail Iordanov, Ph.D.

Mihail Iordanov Ph.D.

  • 5034945418
The question of whether an individual cell lives or dies is of paramount importance not only for the cell itself, but also for the multicellular organism that harbors it. Our research is oriented towards the understanding of the mechanisms of cell survival and programmed cell death (apoptosis) in specific cell types. For instance, one major project focuses on the signal transduction events that underlie the pro-survival and pro-apoptotic responses of human keratinocytes (the main cell type of the epidermis) to ultraviolet (UV) radiation, a relevant human skin carcinogen. We apply a plethora of molecular and cellular approaches to investigate the involvement of signaling proteins (e.g. receptors for growth factors and cytokines, GTPases, kinases, phosphatases, and transcription factors) in mediating the decisions of keratinocytes to survive or to commit cell suicide following exposure to UV. One example of a particular signaling pathway we investigate is the UV-induced regulation of the Ras GTPases and their downstream effectors, the extracellular signal-regulated kinases ERK1 and ERK2. Another major project focuses on the roles played by the stress-activated protein kinases JNK1 and JNK2 in the protective responses to toxic electrophilic compounds that challenge the cellular antioxidant defenses and cause oxidative stress. These compounds are either environmental pollutants (e.g. arsenic) or drug metabolites produced inside cells by cellular drug-activating enzymes. Our research may lead to the development of novel strategies for counteracting the harmful impact of important environmental pollutants and human.

Memberships and associations

  • Cell &Developmental Biology

Publications

  • "Proximal giant neurofilamentous axonopathy in mice genetically engineered to resist calpain and caspase cleavage of α-II spectrin." Journal of Molecular Neuroscience In: , Vol. 47, No. 3, 07.2012, p. 631-638.
  • "Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome." Cancer Biology and Therapy In: , Vol. 11, No. 12, 15.06.2011, p. 1008-1016.
  • "An epidermotypic model of interface dermatitis reveals individual functions of fas ligand and gamma interferon in hypergranulosis, cytoid body formation, and gene expression." American Journal of Dermatopathology In: , Vol. 33, No. 3, 05.2011, p. 244-250.
  • "ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells." Cancer Biology and Therapy In: , Vol. 10, No. 3, 01.08.2010, p. 258-266.
  • "Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo : Implications for psoriasis pathogenesis." Journal of Investigative Dermatology  In: , Vol. 129, No. 9, 09.2009, p. 2175-2183.
  • "Fas ligand-induced proinflammatory transcriptional responses in reconstructed human epidermis : Recruitment of the epidermal growth factor receptor and activation of MAP kinases." Journal of Biological Chemistry In: , Vol. 283, No. 2, 11.01.2008, p. 919-928.
  • "Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages." Molecular Immunology  In: , Vol. 44, No. 10, 04.2007, p. 2761-2771.
  • "c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP." Journal of Biological Chemistry  In: , Vol. 281, No. 46, 17.11.2006, p. 34810-34815.
  • "Fas ligand elicits a caspase-independent proinflammatory response in human keratinocytes : Implications for Dermatitis." Journal of Investigative Dermatology In: , Vol. 126, No. 11, 15.11.2006, p. 2438-2451.
  • "D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells." BMC Cell Biology In: , Vol. 7, 02.01.2006.
  • "D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells." BMC Cell Biology In: , Vol. 7, 7, 2006.
  • "Cell death-induced activation of epidermal growth factor receptor in keratinocytes : Implications for restricting epidermal damage in dermatitis." Journal of Investigative Dermatology In: , Vol. 125, No. 1, 07.2005, p. 134-142.
  • "Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and p38 MAPK and provides a mouse model of hemolytic uremic syndrome." American Journal of Pathology  In: , Vol. 166, No. 1, 01.2005, p. 323-339.
  • "Two mechanisms of caspase 9 processing in double-stranded RNA- and virus-triggered apoptosis." Apoptosis In: , Vol. 10, No. 1, 01.2005, p. 153-166.
  • "Recruitment of TRADD, FADD, and caspase 8 to double-stranded RNA-triggered death inducing signaling complexes (dsRNA-DISCs)." Apoptosis In: , Vol. 10, No. 1, 01.2005, p. 167-176.
  • "Chronic Liver Disease in Murine Hereditary Tyrosinemia Type 1 Induces Resistance to Cell Death." Hepatology  In: , Vol. 39, No. 2, 02.2004, p. 433-443.
  • "The UV (ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor." Molecular and Cellular Biology In: , Vol. 22, No. 15, 2002, p. 5380-5394.
  • "Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents." Critical Reviews in Oncology/Hematology In: , Vol. 39, No. 1-2, 2001, p. 79-86.
  • "Activation of NF-κB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs." Molecular and Cellular Biology In: , Vol. 21, No. 1, 2001, p. 61-72.
  • "Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase : Evidence for cytotoxic mechanisms different from inhibition of protein synthesis." Cancer Research In: , Vol. 60, No. 7, 01.04.2000, p. 1983-1994.
  • "Activation of p38 mitogen-activated protein kinase and c-Jun NH2- terminal kinase by double-stranded RNA and encephalomyocarditis virus : Involvement of RNase L, protein kinase R, and alternative pathways." Molecular and Cellular Biology In: , Vol. 20, No. 2, 01.2000, p. 617-627.
  • "Differential requirement for the stress-activated protein kinase/c-Jun NH2-terminal kinase in RNA damage-induced apoptosis in primary and in immortalized fibroblasts." Molecular Cell Biology Research Communications In: , Vol. 4, No. 2, 2000, p. 122-128.
  • "Different mechanisms of c-Jun NH2-terminal kinase-1 (JNK1) activation by ultraviolet-B radiation and by oxidative stressors." Journal of Biological Chemistry In: , Vol. 274, No. 36, 03.09.1999, p. 25801-25806.
  • "The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53." Biochemical and Biophysical Research Communications  In: , Vol. 261, No. 2, 02.08.1999, p. 464-471.
  • "Ultraviolet radiation triggers the ribotoxic stress response in mammalian cells." Journal of Biological Chemistry In: , Vol. 273, No. 25, 19.06.1998, p. 15794-15803.
  • "Loss of cellular K+ mimics ribotoxic stress. Inhibition of protein synthesis and activation of the stress kinases SEK1/MKK4, stress-activated protein kinase/c-Jun NH2-terminal kinase 1, and p38/HOG1 by palytoxin." Journal of Biological Chemistry In: , Vol. 273, No. 6, 06.02.1998, p. 3528-3534.
  • "Ribotoxic stress response : Activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the α-sarcin/ricin loop in the 28S rRNA." Molecular and Cellular Biology In: , Vol. 17, No. 6, 06.1997, p. 3373-3381.
  • "CREB is activated by UVC through a p38/HOG-1-dependent protein kinase." EMBO Journal In: , Vol. 16, No. 5, 03.03.1997, p. 1009-1022.
  • "UV-induced signal transduction." Journal of photochemistry and photobiology. B, Biology In: , Vol. 37, No. 1-2, 01.1997, p. 1-17.
  • "New trends in photobiology (Invited review). UV-induced signal transduction." Journal of Photochemistry and Photobiology B: Biology In: , Vol. 37, No. 1-2, 01.1997, p. 1-17.

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