Photo of Michael Klein, M.D.

Michael Klein M.D.

Dr. Klein specializes in retinal disease. His research interests include macular degeneration, retinal vascular diseases and diabetic retinopathy.

Education

  • M.D., Northwestern University Medical School, Chicago Illinois 1966
  • Residency:

    • Ophthalmology-University of Illinois Eye and Ear Infirmary, Chicago
  • Fellowship:

    • Retina-Boston University, Retina-Wilmer Institute, Johns Hopkins, Baltimore
  • Certifications:

    • American Board of Ophthalmology

Publications

  • "Bivariate analysis of age-related macular degeneration progression using genetic risk scores." Genetics  In: , Vol. 206, No. 1, 01.05.2017, p. 119-133.
  • "Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits." Genome Medicine  In: , Vol. 9, No. 1, 29, 27.03.2017.
  • "A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants." Nature Genetics In: , Vol. 48, No. 2, 01.02.2016, p. 134-143.
  • "Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration." Ophthalmology In: , Vol. 122, No. 11, 01.11.2015, p. 2286-2294.
  • "Reply." Ophthalmology In: , Vol. 122, No. 10, 01.10.2015, p. e61-e62.
  • "Reply." Ophthalmology In: , Vol. 122, No. 10, 01.10.2015, p. e63.
  • "Reply." Ophthalmology In: , Vol. 122, No. 10, 01.10.2015, p. e58-e59.
  • "Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials." Ophthalmology In: , Vol. 122, No. 9, 01.09.2015, p. 1846-1853.
  • "Author reply." Ophthalmology In: , Vol. 122, No. 8, 01.08.2015, p. e46-e47.
  • "Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration." PLoS One  In: , Vol. 10, No. 5, e0126636, 11.05.2015.
  • "Genetic testing in persons with age-related macular degeneration and the use of the AREDS supplements : To test or not to test?" Ophthalmology In: , Vol. 122, No. 1, 01.01.2015, p. 212-215.
  • "No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements : AREDS report number 38." Ophthalmology In: , Vol. 121, No. 11, 01.11.2014, p. 2173-2180.
  • "Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration." Human Molecular Genetics  In: , Vol. 23, No. 21, 01.11.2014, p. 5827-5837.
  • "Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression AREDS2 report no. 3." JAMA Ophthalmology In: , Vol. 132, No. 2, 02.2014, p. 142-149.
  • "Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials." Ophthalmology In: , Vol. 121, No. 1, 01.2014, p. 150-161.
  • "Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration." Ophthalmology  In: , Vol. 121, No. 7, 2014, p. 1435-1444.
  • "Prevalence of anti-retinal autoantibodies in different stages of Age-related macular degeneration." BMC Ophthalmology In: , Vol. 14, 2014, p. 154.
  • "Genetic evidence for role of carotenoids in age-related macular degeneration in the carotenoids in age-related eye disease study (CAREDS)." Investigative Ophthalmology and Visual Science In: , Vol. 55, No. 1, 17.12.2013, p. 587-599.
  • "Identification of a rare coding variant in complement 3 associated with age-related macular degeneration." Nature Genetics In: , Vol. 45, No. 11, 11.2013, p. 1375-1381.
  • "Lutein/zeaxanthin for the treatment of age-related cataract : AREDS2 randomized trial report no. 4." JAMA Ophthalmology  In: , Vol. 131, No. 7, 07.2013, p. 843-850.
  • "Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration : The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial." JAMA - Journal of the American Medical Association  In: , Vol. 309, No. 19, 15.05.2013, p. 2005-2015.
  • "Seven new loci associated with age-related macular degeneration." Nature Genetics In: , Vol. 45, No. 4, 04.2013, p. 433-439.
  • "Pharmacogenetics for genes associated with age-related macular degeneration in the comparison of AMD treatments trials (CATT)." Ophthalmology In: , Vol. 120, No. 3, 03.2013, p. 593-599.
  • "Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations." Journal of Nutrition In: , Vol. 143, No. 1, 01.2013, p. 17-26.
  • "Baseline predictors for one-year visual outcomes with ranibizumab or bevacizumab for neovascular age-related macular degeneration." Ophthalmology In: , Vol. 120, No. 1, 01.2013, p. 122-129.
  • "Genetic determinants of macular pigments in women the carotenoids in age-related eye disease study." Investigative Ophthalmology and Visual Science In: , Vol. 54, No. 3, 2013, p. 2333-2345.
  • "Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration." Cell Reports In: , Vol. 2, No. 5, 29.11.2012, p. 1151-1158.
  • "The related transcriptional enhancer factor-1 Isoform, TEAD4216, can repress vascular endothelial growth factor expression in mammalian cells." PLoS One  In: , Vol. 7, No. 6, e31260, 22.06.2012.
  • "Risk assessment model for development of advanced age-related macular degeneration." Archives of Ophthalmology In: , Vol. 129, No. 12, 12.2011, p. 1543-1550.
  • "Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies." Human Mutation  In: , Vol. 32, No. 12, 12.2011, p. 1407-1416.

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