Photo of Matthew Lattal, Ph.D.

Matthew Lattal Ph.D.

  • (503) 418-2215
    • Professor of Behavioral Neuroscience School of Medicine
    • Behavioral Neuroscience Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine

Summary of Current Research
My research is focused on understanding how new memories form and how, once formed, these memories can be modulated or weakened through environmental and pharmacological interventions.  Research in my lab investigates memory at three different levels of analysis.  At the behavioral level, we are interested in how different environmental experiences can cause memories to be formed or suppressed.  At the neurobiological systems level, we focus on how brain circuits that mediate memory are altered by behavioral experience.  At the molecular level, we investigate whether manipulating epigenetic processes can modulate long-term memories.  Recent work has focused on the control of gene expression by pharmacological modulation of chromatin, the protein complex that packages genomic DNA.  Relaxing chromatin structure by administering a histone deacetylase (HDAC) inhibitor can promote gene expression by facilitating interactions between transcription factors and DNA.  We have found that HDAC inhibitors promote the development and persistence of different kinds of memories.  At a molecular level, these findings reinforce the idea that regulation of gene expression via chromatin modification is critical for memory.  At a clinical level, these findings suggest that modulating chromatin modification during an episode of learning may lead to a persistent form of memory.

Previous Positions
2010-2016  Associate Professor, Department of Behavioral Neuroscience, OHSU

2005-2010  Assistant Professor, Department of Behavioral Neuroscience, OHSU

1998-2004 Post-Doctoral Fellow, Department of Biology, University of Pennsylvania (Advisor: Ted Abel)

Areas of interest

  • Neurobiology of learning and memory
  • Models of substance abuse and post-traumatic stress disorder
  • Learning theory
  • Pharmacological approaches to enhancing memory
  • Epigenetic mechanisms of memory

Education

  • B.A., University of California San Diego 1993
  • Ph.D., University of Pennsylvania 1998

Publications

Selected publications

  • Abraham, A.D., Neve, K.A., & Lattal, K.M. (2016).  Effects of D1 receptor knockout on fear and reward learning.  Neurobiology of Learning & Memory, 133, 265-273.

  • Abraham, A.D., Neve, K.A., & Lattal, K.M. (2016).  Activation of D1/5 dopamine receptors: A common mechanism for enhancing extinction of fear and reward-seeking behaviors.  Neuropsychopharmacology, 41, 2072–2081.

  • Crabbe, J.C., Schlumbohm, J. P., Hack, W., Barkley-Levenson, A. M., Metten, P., & Lattal, K.M. (2016).  Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking.  Alcohol, 52, 25-32.

  • Tipps, M.E., Raybuck, J.D., Buck, K.J., & Lattal, K.M. (2014).  Delay and trace fear conditioning in C57BL/6 and DBA/2 mice: Issues of measurement and performance.  Learning & Memory, 21, 380-393.

  • Hitchcock, L.N., Cunningham, C.L., & Lattal, K.M. (2014).  Cue configuration effects in acquisition and extinction of a cocaine-induced place preference.  Behavioral Neuroscience, 128, 217-227.

  • Stafford, J.M., Maughan, D.K., Ilioi, E.C., & Lattal, K.M. (2013). Exposure to a fearful context during periods of memory plasticity impairs extinction via hyperactivation of frontal-amygdalar circuits.  Learning & Memory, 20, 156-163.

  • Lattal, K.M. & Wood, M.A. (2013).  Epigenetics and persistent memory: Implications for reconsolidation and silent extinction beyond the zero.  Nature Neuroscience, 16, 124-129.

  • Stafford, J.M., Raybuck, J.D., Ryabinin, A., & Lattal, K.M. (2012).  Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction.  Biological Psychiatry, 72, 25-33.

Publications

  • "Involvement of the dorsal hippocampus in expression and extinction of cocaine-induced conditioned place preference." Hippocampus  In: , Vol. 28, No. 3, 01.03.2018, p. 226-238.
  • "Persistent effects of acute stress on fear and drugseeking in a novel model of the comorbidity between post-traumatic stress disorder and addiction." Learning and Memory  In: , Vol. 24, No. 9, 01.09.2017, p. 422-431.
  • "Reconsolidation and extinction : Using epigenetic signatures to challenge conventional wisdom." Neurobiology of Learning and Memory In: , 09.11.2016.
  • "Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking." Alcohol  In: , Vol. 52, 01.05.2016, p. 25-32.
  • "Effects of D1 receptor knockout on fear and reward learning." Neurobiology of Learning and Memory  In: , 13.04.2016.
  • "Activation of D1/5 Dopamine Receptors : A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors." Neuropsychopharmacology  In: , 14.01.2016.
  • "G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock-Out Mice Show Enhanced Ethanol Reward." Alcoholism: Clinical and Experimental Research In: , 2016.
  • "Acute Ethanol Withdrawal Impairs Contextual Learning and Enhances Cued Learning." Alcoholism: Clinical and Experimental Research  In: , Vol. 39, No. 2, 01.02.2015, p. 282-290.
  • "Epigenetics and memory : Causes, consequences and treatments for post-traumatic stress disorder and addiction." Genes, Brain and Behavior In: , Vol. 14, No. 1, 01.01.2015, p. 73-84.
  • "Large-scale topology and the default mode network in the mouse connectome." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 111, No. 52, 30.12.2014, p. 18745-18750.
  • "Differential effects of dorsal hippocampal inactivation on expression of recent and remote drug and fear memory." Neuroscience Letters In: , Vol. 569, 21.05.2014, p. 1-5.
  • "Cue configuration effects in acquisition and extinction of a cocaine-induced place preference." Behavioral Neuroscience  In: , Vol. 128, No. 2, 01.04.2014, p. 217-227.
  • "Dopamine and extinction : A convergence of theory with fear and reward circuitry." Neurobiology of Learning and Memory  In: , Vol. 108, 02.2014, p. 65-77.
  • "The study of associative learning : Mapping from psychological to neural levels of analysis." Neurobiology of Learning and Memory In: , Vol. 108, 02.2014, p. 1-4.
  • "Bridging the interval : Theory and neurobiology of trace conditioning." Behavioural Processes  In: , Vol. 101, 01.2014, p. 103-111.
  • "Delay and trace fear conditioning in C57BL/6 and DBA/2 mice : Issues of measurement and performance." Learning and Memory  In: , Vol. 21, No. 8, 2014, p. 380-393.
  • "Substance abuse, memory, and post-traumatic stress disorder." Neurobiology of Learning and Memory  In: , Vol. 112, 2014, p. 87-100.
  • "Histone-mediated epigenetics in addiction." Progress in Molecular Biology and Translational Science  In: , Vol. 128, No. C, 2014, p. 51-87.
  • "Opposing effects of d-cycloserine on fear despite a common extinction duration : Interactions between brain regions and behavior." Neurobiology of Learning and Memory  In: , Vol. 113, 2014, p. 25-34.
  • "Inhibition of soluble epoxide hydrolase after cardiac arrest/ cardiopulmonary resuscitation induces a neuroprotective phenotype in activated microglia and improves neuronal survival." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 33, No. 10, 10.2013, p. 1574-1581.
  • "The histone deacetylase inhibitor sodium butyrate modulates acquisition and extinction of cocaine-induced conditioned place preference." Pharmacology Biochemistry and Behavior  In: , Vol. 106, 05.2013, p. 109-116.
  • "Exposure to a fearful context during periods of memory plasticity impairs extinction via hyperactivation of frontal-amygdalar circuits." Learning and Memory  In: , Vol. 20, No. 3, 03.2013, p. 156-163.
  • "Epigenetics and persistent memory : Implications for reconsolidation and silent extinction beyond the zero." Nature Neuroscience In: , Vol. 16, No. 2, 02.2013, p. 124-129.
  • "Prazosin differentially affects extinction of cocaine conditioned place preference on the basis of dose and initial preference." NeuroReport  In: , Vol. 23, No. 18, 19.12.2012, p. 1048-1051.
  • "Post-conditioning propranolol disrupts cocaine sensitization." Pharmacology Biochemistry and Behavior  In: , Vol. 102, No. 4, 10.2012, p. 515-519.
  • "Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos." NeuroToxicology  In: , Vol. 33, No. 4, 08.2012, p. 660-668.
  • "Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction." Biological Psychiatry  In: , Vol. 72, No. 1, 01.07.2012, p. 25-33.
  • "Facets of Pavlovian and operant extinction." Behavioural Processes In: , Vol. 90, No. 1, 05.2012, p. 1-8.
  • "SQAB 2011 : Extinction." Behavioural Processes In: , Vol. 90, No. 1, 05.2012.
  • "A parametric analysis of factors affecting acquisition and extinction of contextual fear in C57BL/6 and DBA/2 mice." Behavioural Processes In: , Vol. 90, No. 1, 05.2012, p. 49-57.

Additional information

Edit profile