Photo of Matthew Butler, Ph.D.

Matthew Butler Ph.D.

  • (503) 418-4310
    • Assistant Professor Oregon Institute of Occupational Health Sciences
    • Behavioral Neuroscience Graduate Program School of Medicine

I have a broad interest in how biological clocks are synchronized in organisms, and how these affect physiology and behavior. I have a particular interest in how shift work increases the risk for disease. Current efforts employ behavioral and physiological approaches in order to investigate the following:

1)    The effects of clock synchrony on cardiometabolic health.
2)    How the circadian clock governs sleep apnea severity in humans.
3)    Temporal patterns of sleep apnea as predictors of mortality.
4)    How the time of day of a traumatic brain injury changes its severity and prognosis.

Areas of interest

  • The effects of clock synchrony on cardiometabolic health.
  • How the circadian clock governs sleep apnea severity in humans.
  • Temporal patterns of sleep apnea as predictors of mortality.


  • A.B., Dept. of Ecology and Evolutionary Biology, Princeton University, Princeton New Jersey United States 1999
  • Ph.D., Dept. of Integrative Biology, U.C. Berkeley, Berkeley California United States 2007

Memberships and associations

  • Society for Research on Biological Rhythms
  • American Association of Sleep Medicine
  • Sleep Research Society


  • Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP. 2015. Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep. 38:1849-60.

  • Butler MP, Smales C, Wu H, Hussain MV, Mohamed YA, Morimoto M, Shea SA. 2015. The circadian system contributes to apnea lengthening across the night in obstructive sleep apnea. Sleep 38: 1793-1801.

  • Model Z, Butler MP, LeSauter J, Silver R. 2015. Suprachiasmatic nucleus as the site of androgen action on circadian rhythms. Hormones and Behavior. 73:1-7.

  • Pittman-Polletta B, Scheer FAJL, Butler MP, Shea SA, Hu K. 2013. The role of the circadian system in fractal neurophysiological control. Biological Reviews 88: 873-894, 2013. PMCID: PMC3766492.

  • Butler MP, Rainbow MN, Rodriguez E, Lyon SM, Silver R. 2012. Twelve hour days in the brain and behavior of split hamsters. European Journal of Neuroscience. 36: 2556-66. PMCID: PMC4014115.

  • Butler MP, Karatsoreos IN, LeSauter J, Silver R. 2012. Dose-dependent effects of androgens on the circadian timing system and its response to light. Endocrinology. 153: 2344-2352. PMCID: PMC3339642.

  • Silver R, Balsam P, Butler MP, LeSauter J. 2011. Food anticipation depends on oscillators and memories in both body and brain.  Physiology and Behavior. 104: 562-71. PMCID: PMC3378387.

  • Butler MP, Silver R.  2011. Divergent photic thresholds in the non-image forming visual system: entrainment, masking, and pupillary light reflex. Proceedings of the Royal Society B: Biological Sciences. 278: 745-750. PMCID: PMC3030845.

  • Butler MP, Silver R.  2009.  Basis of robustness and resilience in the suprachiasmatic nucleus: Individual neurons form nodes in circuits that cycle daily.  Journal of Biological Rhythms 24: 340-352. PMCID: PMC3104278.

  • Butler MP, Trumbull JJ, Turner KW, Zucker I.  2007.  Timing of puberty and synchronization of seasonal rhythms by simulated natural photoperiods in female Siberian hamsters.  American Journal of Physiology 293: R413-R420.

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