Photo of Martina Ralle, Ph.D.

Martina Ralle Ph.D.

    • Assistant Professor of Molecular and Medical Genetics School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Publications

  • "Copper, zinc and calcium : Imaging and quantification in anterior pituitary secretory granules." Metallomics  In: , Vol. 8, No. 9, 01.09.2016, p. 1012-1022.
  • "The activity of Menkes disease protein ATP7A is essential for redox balance in mitochondria." Journal of Biological Chemistry  In: , Vol. 291, No. 32, 05.08.2016, p. 16644-16658.
  • "Systemic Delivery and Biodistribution of Cisplatin in Vivo." Molecular Pharmaceutics In: , Vol. 13, No. 8, 01.08.2016, p. 2677-2682.
  • "Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease." Journal of Nutritional Biochemistry In: , Vol. 26, No. 10, 01.10.2015, p. 996-1006.
  • "Adaptor protein-1 complex affects the endocytic trafficking and function of peptidylglycine α-amidating monooxygenase, a luminal cuproenzyme." Journal of Biological Chemistry In: , Vol. 290, No. 35, 28.08.2015, p. 21264-21279.
  • "Modulation of tau phosphorylation by environmental copper." Translational Neurodegeneration In: , Vol. 3, No. 1, 24, 17.11.2014.
  • "Biological X-ray fluorescence microscopy : Advances and unique opportunities." Microscopy and Microanalysis In: , Vol. 20, No. 3, 01.08.2014, p. 1306-1307.
  • "Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum." BMC Endocrine Disorders In: , Vol. 14, 58, 15.07.2014.
  • "In vivo and in vitro analyses of amygdalar function reveal a role for copper." Journal of Neurophysiology In: , Vol. 111, No. 10, 2014, p. 1927-1939.
  • "Oral zinc reduces amyloid burden in Tg2576 mice." Journal of Alzheimer's Disease In: , Vol. 41, No. 1, 2014, p. 179-192.
  • "Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity." Journal of Neurochemistry In: , Vol. 127, No. 5, 12.2013, p. 605-619.
  • "Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- And cisplatin-binding ecto-domain." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 110, No. 46, 12.11.2013.
  • "Opportunities in multidimensional trace metal imaging : Taking copper-associated disease research to the next level." Analytical and Bioanalytical Chemistry  In: , Vol. 405, No. 6, 2013, p. 1809-1820.
  • "High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics." Experimental Gerontology In: , Vol. 47, No. 7, 07.2012, p. 491-496.
  • "Occult intraocular foreign body masquerading as panuveitis : Inductively coupled mass spectrometry and electrophysiologic analysis." Journal of Ophthalmic Inflammation and Infection  In: , Vol. 2, No. 2, 06.2012, p. 99-103.
  • "Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease." Journal of Molecular Biology  In: , Vol. 406, No. 1, 11.02.2011, p. 44-58.
  • "Gender effects on plasma and brain copper." International Journal of Alzheimer's Disease  In: , 2011.
  • "Phytic acid as a potential treatment for Alzheimer's pathology : Evidence from animal and in vitro models." Journal of Alzheimer's Disease In: , Vol. 23, No. 1, 2011, p. 21-35.
  • "Wilson disease at a single cell level : Intracellular copper trafficking activates compartment-specific responses in hepatocytes." Journal of Biological Chemistry  In: , Vol. 285, No. 40, 01.10.2010, p. 30875-30883.
  • "Interactions between copper-binding sites determine the redox status and conformation of the regulatory N-terminal domain of ATP7B." Journal of Biological Chemistry  In: , Vol. 285, No. 9, 26.02.2010, p. 6327-6336.
  • "A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease." Journal of Alzheimer's Disease In: , Vol. 21, No. 3, 2010, p. 903-914.
  • "The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation." Biochemistry  In: , Vol. 48, No. 24, 23.06.2009, p. 5573-5581.
  • "Quantitative imaging of metals in tissues." BioMetals  In: , Vol. 22, No. 1, 02.2009, p. 197-205.
  • "High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease." Journal of Biological Chemistry  In: , Vol. 282, No. 11, 16.03.2007, p. 8343-8355.
  • "Large scale production of the copper enzyme peptidylglycine monooxygenase using an automated bioreactor." Protein Expression and Purification In: , Vol. 51, No. 1, 01.2007, p. 34-38.
  • "Using XAS and SXRF to study copper in wilson disease at the molecular and tissue level."   AIP Conference Proceedings. Vol. 882 2007. p. 328-330.
  • "Redox-sensitive transcriptional control by a thiol/disulphide switch in the global regulator, Spx." Molecular Microbiology  In: , Vol. 55, No. 2, 01.2005, p. 498-510.
  • "The selenocysteine-substituted blue copper center : Spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin." Journal of the American Chemical Society In: , Vol. 126, No. 23, 16.06.2004, p. 7244-7256.
  • "Copper transfer to the N-terminal domain of the Wilson disease protein (ATP7B) : X-ray absorption spectroscopy of reconstituted and chaperone-loaded metal binding domains and their interaction with exogenous ligands." Journal of Inorganic Biochemistry In: , Vol. 98, No. 5, 05.2004, p. 765-774.
  • "The N-terminal Metal-binding Site 2 of the Wilson's Disease Protein Plays a Key Role in the Transfer of Copper from Atox1." Journal of Biological Chemistry  In: , Vol. 279, No. 15, 09.04.2004, p. 15376-15384.

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