Photo of Markus Grompe, M.D.

Markus Grompe M.D.

  • (503) 494-8307
    • Professor of Pediatrics School of Medicine
    • Ray Hickey Chair of the of Pape' Family Pediatric Research Institute Pediatrics School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine

Dr. Markus Grompe is the Ray Hickey Professor and Director of the Papé Family Pediatric Research Institute at Oregon Health & Science University in Portland, Oregon, USA. His research has focused on the use of in vivo selection to enhance gene and cell transplantation therapy for inherited diseases. Hepatic stem cells and their use in therapeutic liver repopulation are a main focus. To study the properties of human cells in a physiologic setting the laboratory has developed murine models supporting the expansion of human stem cells in transgenic mice.  These humanized mice are an ideal platform for the development for novel therapeutics, including small molecules, gene therapy vectors and cells. He has published over 200 peer-reviewed articles and holds numerous patents.

Education

  • M.D., University of Ulm Medical School, 0 Germany 1983
  • Residency:

    • Pediatrics, Oregon Health & Science University, Portland, 1987
  • Fellowship:

    • Genetics, Baylor College of Medicine, Houston, TX, 1991
  • Certifications:

    • Clinical Genetics

Memberships and associations

  • Diplomat of the American Board of Human Genetics

Publications

  • "A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia." Cell Stem Cell In: , Vol. 20, No. 4, 06.04.2017, p. 478-489.e5.
  • "Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1." American Journal of Pathology In: , Vol. 187, No. 1, 01.01.2017, p. 33-41.
  • "Successful engraftment of human hepatocytes in uPA- SCID and FRG® KO mice."   Methods in Molecular Biology. Vol. 1506 Humana Press Inc., 2017. p. 117-130 (Methods in Molecular Biology; Vol. 1506).
  • "Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice." Blood  In: , Vol. 128, No. 24, 15.12.2016, p. 2774-2784.
  • "Efficient generation of pancreatic β-like cells from the mouse gallbladder." Stem Cell Research  In: , Vol. 17, No. 3, 01.11.2016, p. 587-596.
  • "Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas." Cell Metabolism In: , Vol. 24, No. 4, 11.10.2016, p. 616-626.
  • "Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma." Human Mutation In: , Vol. 37, No. 10, 01.10.2016, p. 1097-1105.
  • "Stem Cells and Regeneration in the Digestive System : Keystone Meeting." Gastroenterology  In: , Vol. 151, No. 3, 01.09.2016, p. e6-e9.
  • "Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1." Science Translational Medicine In: , Vol. 8, No. 349, 349ra99, 27.07.2016.
  • "Human islets contain four distinct subtypes of β cells." Nature Communications  In: , Vol. 7, 11756, 11.07.2016.
  • "A universal system to select gene-modified hepatocytes in vivo." Science Translational Medicine  In: , Vol. 8, No. 342, 342ra79, 08.06.2016.
  • "Age-dependent pancreatic gene regulation reveals mechanisms governing human β cell function." Cell Metabolism In: , Vol. 23, No. 5, 10.05.2016, p. 909-920.
  • "TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in Fanconi anemia." Cell Stem Cell In: , Vol. 18, No. 5, 05.05.2016, p. 668-681.
  • "Identification of tissue-specific cell death using methylation patterns of circulating DNA." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 113, No. 13, 29.03.2016, p. E1826-E1834.
  • "Stem cells versus plasticity in liver and pancreas regeneration." Nature Cell Biology  In: , Vol. 18, No. 3, 25.02.2016, p. 238-245.
  • "Adeno-associated virus finds its disease." Nature Genetics  In: , Vol. 47, No. 10, 29.09.2015, p. 1104-1105.
  • "Fibroblast Growth Factor Signaling Controls Liver Size in Mice with Humanized Livers." Gastroenterology  In: , Vol. 149, No. 3, 01.09.2015, p. 728e15-740e15.
  • "Directed differentiation of cholangiocytes from human pluripotent stem cells." Nature Biotechnology  In: , Vol. 33, No. 8, 10.08.2015, p. 853-861.
  • "Novel surface markers directed against adult human gallbladder." Stem Cell Research  In: , Vol. 15, No. 1, 01.07.2015, p. 172-181.
  • "The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice." Stem Cell Research  In: , Vol. 15, No. 1, 01.07.2015, p. 130-140.
  • "Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling." Stem Cell Reports  In: , Vol. 4, No. 1, 13.01.2015, p. 90-102.
  • "Extensive double humanization of both liver and hematopoiesis in FRGN mice." Stem Cell Research In: , No. Part A, 01.11.2014, p. 404-412.
  • "Erratum : Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype (Nature Biotechnology DOI: 10.1038/nbt.2884)." Nature Biotechnology In: , Vol. 32, No. 9, 01.09.2014, p. 952.
  • "Pharmacologic inhibition of L-tyrosine degradation ameliorates cerebral dopamine deficiency in murine phenylketonuria (PKU)." Journal of Inherited Metabolic Disease  In: , Vol. 37, No. 5, 01.09.2014, p. 735-743.
  • "Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model." Pediatric Blood and Cancer  In: , Vol. 61, No. 4, 04.2014, p. 740-742.
  • "The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar." Stem Cell Research  In: , Vol. 13, No. 2, 2014, p. 275-283.
  • "Selection and evaluation of clinically relevant AAV variants in a xenograft liver model." Nature In: , Vol. 506, No. 7488, 2014, p. 382-386.
  • "Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes." Cell Stem Cell  In: , Vol. 15, No. 5, 2014, p. 605-618.
  • "Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype." Nature Biotechnology In: , Vol. 32, No. 6, 2014, p. 551-553.
  • "Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease." Stem Cell Research In: , Vol. 13, No. 1, 2014, p. 144-153.

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