Photo of Mark Pennesi, M.D., Ph.D.

Mark Pennesi M.D., Ph.D.

Dr. Pennesi was born in Mount Kisco, New York, and moved to Dallas, Texas at a young age. For college, he moved to the east coast and attended the University of Pennsylvania for his undergraduate studies. There he graduated summa cum laude with a BS in biomedical engineering and was awarded the Herman P. Schwann award in bioengineering for exemplary scholarship.

Dr. Pennesi's interest in degenerative retinal disorders began shortly after his first year in college, when he spent a summer working at the Retina Foundation of the Southwest. He worked under the supervision of Dr. David Birch and saw patients with retinal degenerations such as retinitis pigmentosa as well as studying animal models of this disease.

After college, Dr. Pennesi completed a combined M.D./Ph.D. at Baylor College of Medicine in Houston, Texas. He performed his graduate Ph.D. work in the Department of Neuroscience in the lab of Dr. Samuel Wu. His thesis work focused on identifying new animal models of retinal degeneration. He received numerous awards while in graduate school, including the John J. Trentin Award for earning the highest GPA in his class and the BRASS scholarship for playing an active role in community service.

For his residency training, Dr. Pennesi spent his internship year in San Diego at Scripps Mercy Hospital, followed by his ophthalmology residency at the University of California, San Francisco. During residency he was awarded the Hogan/Garcia award for the best resident research project. After residency he completed an ophthalmic genetics fellowship under the tutelage of Dr. Richard Weleber.

Dr. Pennesi joined the faculty of Casey Eye Institute and is now an Associate Professor in Ophthalmic Genetics and as the chief of the Ophthalmic Genetics Division.

Both Research to Prevent Blindness and the Foundation Fighting Blindness have recognized Dr. Pennesi with career development awards to support his ambition to conduct transitional research that will bring treatments for diseases such as retinitis pigmentosa from the laboratory to the clinic. Additionally, he is the recipient of the 2011 ARVO/Alcon Early Clinician Scientist, the Alcon Young investigator Award in 2014, and the Casey Eye Institute Resident teach award. His research focuses on developing novel treatments for inherited retinal diseases. He is currently exploring the potential of a new class of drugs to up regulate protective growth factors in the retina.

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Education

  • Ph.D., Baylor College of Medicine, Houston Texas 2003
  • B.S., University of Pennsylvania, Philadelphia Pennsylvania 1997
  • M.D., Baylor College of Medicine, Houston Texas 2004
  • Residency:

    • Transitional year, Scripps Mercy Hospital, San Diego, California, 2005
  • Fellowship:

    • Ophthalmic genetics fellowship, Casey Eye Institute, Oregon Health & Science University, 2009
  • Certifications:

    • American Board of Ophthalmology, 2010

Publications

  • "Measurement and Reproducibility of Preserved Ellipsoid Zone Area and Preserved Retinal Pigment Epithelium Area in Eyes With Choroideremia." American Journal of Ophthalmology  In: , Vol. 179, 01.07.2017, p. 110-117.
  • "Specific alleles of CLN7/MFSD8, a protein that localizes to photoreceptor synaptic terminals, cause a spectrum of nonsyndromic retinal dystrophy." Investigative Ophthalmology and Visual Science  In: , Vol. 58, No. 7, 01.06.2017, p. 2906-2914.
  • "Long-term characterization of retinal degeneration in royal college of surgeons rats using spectral-domain optical coherence tomography." Investigative Ophthalmology and Visual Science In: , Vol. 58, No. 3, 01.03.2017, p. 1378-1386.
  • "REPEATABILITY AND LONGITUDINAL ASSESSMENT OF FOVEAL CONE STRUCTURE IN CNGB3-ASSOCIATED ACHROMATOPSIA." Retina  In: , 31.01.2017.
  • "Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography." Biomedical Optics Express  In: , Vol. 8, No. 1, #276323, 01.01.2017, p. 48-56.
  • "ULTRA–WIDE-FIELD FUNDUS AUTOFLUORESCENCE FINDINGS IN PATIENTS WITH ACUTE ZONAL OCCULT OUTER RETINOPATHY." Retina  In: , 17.10.2016.
  • "Interpretation of flood-illuminated adaptive optics images in subjects with Retinitis Pigmentosa."  Advances in Experimental Medicine and Biology. Vol. 854 Springer New York LLC, 2016. p. 291-297 (Advances in Experimental Medicine and Biology; Vol. 854).
  • "Long-term Follow-up of Patients With Retinitis Pigmentosa Receiving Intraocular Ciliary Neurotrophic Factor Implants." American Journal of Ophthalmology In: , Vol. 170, 01.10.2016, p. 10-14.
  • "Characterization of Chorioretinopathy Associated with Mitochondrial Trifunctional Protein Disorders : Long-Term Follow-up of 21 Cases." Ophthalmology In: , Vol. 123, No. 10, 01.10.2016, p. 2183-2195.
  • "Residual foveal cone structure in CNGB3-associated achromatopsia." Investigative Ophthalmology and Visual Science  In: , Vol. 57, No. 10, 01.08.2016, p. 3984-3995.
  • "Molecular and clinical findings in patients with knobloch syndrome." JAMA Ophthalmology In: , Vol. 134, No. 7, 01.07.2016, p. 753-762.
  • "Retinal neuroprotective effects of flibanserin, an FDA-Approved dual serotonin receptor agonist-antagonist." PLoS One In: , Vol. 11, No. 7, e0159776, 01.07.2016.
  • "OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION IN FOUR INHERITED RETINAL DYSTROPHIES." Retina In: , 22.06.2016.
  • "Quantification of ellipsoid zone changes in retinitis pigmentosa using en face spectral domain-optical coherence tomography." JAMA Ophthalmology In: , Vol. 134, No. 6, 01.06.2016, p. 628-635.
  • "Optical coherence tomography angiography in choroideremia : Correlating choriocapillaris loss with overlying degeneration." JAMA Ophthalmology In: , Vol. 134, No. 6, 01.06.2016, p. 697-702.
  • "Multimodal imaging in Wagner syndrome." Ophthalmic Surgery Lasers and Imaging Retina In: , Vol. 47, No. 6, 01.06.2016, p. 574-579.
  • "Assessing photoreceptor structure in retinitis pigmentosa and usher syndrome." Investigative Ophthalmology and Visual Science  In: , Vol. 57, No. 6, 01.05.2016, p. 2428-2442.
  • "A possible neural mechanism for photosensitivity in chronic pain." Pain In: , Vol. 157, No. 4, 01.04.2016, p. 868-878.
  • "Parafoveal cone abnormalities and recovery on adaptive optics in posterior uveitis." American Journal of Ophthalmology Case Reports  In: , Vol. 1, 01.04.2016, p. 16-22.
  • "Spectrum of ocular manifestations in cobalamin C and cobalamin A types of methylmalonic acidemia." Ophthalmic Genetics In: , 16.03.2016, p. 1-11.
  • "Management of plateau iris syndrome with cataract extraction and endoscopic cyclophotocoagulation." Experimental Eye Research In: , 12.02.2016.
  • "Structure-Function Modeling of Optical Coherence Tomography and Standard Automated Perimetry in the Retina of Patients with Autosomal Dominant Retinitis Pigmentosa." PLoS One  In: , Vol. 11, No. 2, e0148022, 01.02.2016.
  • "Structure/psychophysical relationships in X-linked retinoschisis." Investigative Ophthalmology and Visual Science In: , Vol. 57, No. 2, 01.02.2016, p. 332-337.
  • "Gene therapy trial update : A primer for vitreoretinal specialists." Ophthalmic Surgery Lasers and Imaging Retina In: , Vol. 47, No. 1, 01.01.2016, p. 6-12.
  • "Insights into autosomal dominant stargardt-like macular dystrophy through multimodality diagnostic imaging." Retina In: , Vol. 36, No. 1, 2016, p. 119-130.
  • "Assessing photoreceptor structure associated with ellipsoid zone disruptions visualized with optical coherence tomography." Retina  In: , Vol. 36, No. 1, 2016, p. 91-103.
  • "Corrigendum to "Effects of elevated intraocular pressure on mouse retinal ganglion cells" [Vision Res. 45 (2004) 169-179] DOI : 10.1016/j.visres.2004.08.008." Vision Research In: , Vol. 117, 01.12.2015, p. 136.
  • "Results at 2 Years after Gene Therapy for RPE65-Deficient Leber Congenital Amaurosis and Severe Early-Childhood-Onset Retinal Dystrophy." Ophthalmology  In: , 25.11.2015.
  • "Retinal gene therapy : Current progress and future prospects." Expert Review of Ophthalmology In: , Vol. 10, No. 3, 1035711, 01.06.2015, p. 281-299.
  • "Autosomal dominant retinal dystrophy with electronegative waveform associated with a novel RAX2 mutation." JAMA Ophthalmology In: , Vol. 133, No. 6, 01.06.2015, p. 653-661.

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