Dr. Carbone received her Masters in Biology in 2001 and PhD in Genetics and Molecular Evolution at the University of Bari (Italy) in 2004, under the mentorship of Prof. Mariano Rocchi. During this pre-genomic era, she specialized in comparative cytogenetics and focused her research on chromosome evolution. She also spent two years of her graduate training in Pieter de Jong's lab at the Children's Hospital of Oakland Research Institute (CA) where she then did her postdoctoral training. She joined OHSU as an Assistant Professor in September 2010.
Areas of interest
- Large-scale chromosomal rearrangements are a major source of genetic variation, bring about speciation, and are hallmarks of human disease. However, the mechanisms underlying their occurrence and subsequent fixation are not entirely understood. Using a comparative genomics approach, I investigate how specific genomic and epigenetic features lead to chromosomal rearrangements and the outcome of these events on species evolution and pathology. To this end, I have been using the gibbon genome as a model as these small apes have accumulated an unusually high number of evolutionary chromosomal rearrangements.
- M.S., University of Bari Italy 2001
- Ph.D., University of Bari Italy 2004
- Postdoctoral training (2005-2010), Children's Hospital of Oakland Research Institute
Vitak SA, Torkenczy KA, Rosenkrantz JL, Fields AJ, Christiansen L, Wong MH, Carbone L, Steemers FJ, Adey A Sequencing thousands of single-cell genomes with combinatorial indexing Nat Methods. 2017 Jan 30. doi: 10.1038/nmeth.4154
Meyer JT, Held U, Nevonen KA, Klawitter S, Pirzer T, Carbone L#, Schumann GG# The flow of the gibbon LAVA element is facilitated by the LINE-1 retrotransposition machinery Genome Biol. Evol. 8(10):3209–3225
Eckalbar WL, Schlebusch SA, Mason MK, Gill Z, Booker BM, Nishizaki S, Nday CM, Terhune E, Nevonen KA, Makki N, Friedrich T, VanderMeer JE, Pollard KS, Carbone L, Wall JD, Illing N, Ahituv N Genomic characterization of the developing bat wing. Nat Genet. 2016 May;48(5):528-36
Carbone L#, Harris RA, Gnerre S, Veeramah KR, Lorente-Galdos B, Huddleston J, Meyer TJ, Herrero J, Roos C, Aken B, Anaclerio F, Archidiacono N, Baker C, Barrell D, Batzer MA, Beal K, Blancher A, Bohrson CL, Brameier M, Campbell MS, Capozzi O, Casola C, et al. Gibbon genome and the fast karyotype evolution of small apes. Nature. 2014 Sep 11;513(7517):195-201. doi: 10.1038/nature13679. PMID: 25209798, PMCID: PMC4249732
Carbone L#, Harris RA, Mootnick AR, Milosavljevic A, Martin DI, Rocchi M, Capozzi O, Archidiacono N, Konkel MK, Walker JA, Batzer MA, de Jong PJ. Centromere remodeling in Hoolock leuconedys (Hylobatidae) by a new transposable element unique to the gibbons. Genome Biol Evol. 2012;4(7):648-58. doi: 10.1093/gbe/evs048. Epub 2012 May 16. PMID: 22593550, PMCID: PMC3606032
Carbone L#, Harris RA, Vessere GM, Mootnick AR, Humphray S, Rogers J, Kim SK, Wall JD, Martin D, Jurka J, Milosavljevic A, de Jong PJ. Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution. PLoS Genet. 2009 Jun;5(6):e1000538. doi: 10.1371/journal.pgen.1000538. Epub 2009 Jun 26. PMID: 19557196, PMCID: PMC2695003