I am interested in understanding mechanisms of disrupted sleep and wakefulness associated with illness and injury, and the effects of these disruptions on recovery. My experiences as a nurse working with people following brain injury from stroke, trauma, and cancer who had persistent difficulties with fatigue, disrupted wakefulness, and disrupted sleep drive my interest to develop targeted therapies for these symptoms. I found that cytotoxic chemotherapy disrupts orexin neuropeptide signaling in the brain. This disruption was associated with decreased wakefulness and activity in rodents and replacing orexin restored activity. My current research is on the clinical side of translational research. I study disrupted sleep in Veterans, and the effect of previous traumatic brain injury, post-traumatic stress disorder, and sleep apnea on sleep, functional outcomes, and quality of life. My long term research goal is to improve recovery from brain injury by targeting sleep and wakefulness.
- Ph.D., Oregon Health & Science University Oregon 1910
- B.S., University of California-Davis, Davis California 1910
- M.S., North Carolina State University North Carolina 1910
- B.S.N., Oregon Health & Science University Oregon 1910
- "A role for orexin in cytotoxic chemotherapy-induced fatigue." Brain, Behavior, and Immunity In: , Vol. 37, 03.2014, p. 84-94.
- "The role of IL-1β and TNF-α signaling in the genesis of cancer treatment related symptoms (CTRS) : A study using cytokine receptor-deficient mice." Brain, Behavior, and Immunity In: , Vol. 38, 2014, p. 66-76.
- "Inflammation and neural signaling : Etiologic mechanisms of the cancer treatment-related symptom cluster." Current Opinion in Supportive and Palliative Care In: , Vol. 7, No. 1, 03.2013, p. 54-59.