I am interested in understanding mechanisms of disrupted sleep and wakefulness associated with illness and injury, and the effects of these disruptions on recovery. My experiences as a nurse working with people following brain injury from stroke, trauma, and cancer who had persistent difficulties with fatigue, disrupted wakefulness, and disrupted sleep drive my interest to develop targeted therapies for these symptoms. I found that cytotoxic chemotherapy disrupts orexin neuropeptide signaling in the brain. This disruption was associated with decreased wakefulness and activity in rodents and replacing orexin restored activity. My current research is on the clinical side of translational research. I study disrupted sleep in Veterans, and the effect of previous traumatic brain injury, post-traumatic stress disorder, and sleep apnea on sleep, functional outcomes, and quality of life. My long term research goal is to improve recovery from brain injury by targeting sleep and wakefulness.
Areas of interest
- Disrupted wake-sleep; recovery from head injury; symptom management
- B.S., University of California-Davis, Davis California 1985
- M.S., North Carolina State University North Carolina 1988
- B.S.N., Oregon Health & Science University Oregon 2007
- Ph.D., Oregon Health & Science University Oregon 2013
- "A role for orexin in cytotoxic chemotherapy-induced fatigue." Brain, Behavior, and Immunity In: , Vol. 37, 03.2014, p. 84-94.
- "The role of IL-1β and TNF-α signaling in the genesis of cancer treatment related symptoms (CTRS) : A study using cytokine receptor-deficient mice." Brain, Behavior, and Immunity In: , Vol. 38, 2014, p. 66-76.
- "Inflammation and neural signaling : Etiologic mechanisms of the cancer treatment-related symptom cluster." Current Opinion in Supportive and Palliative Care In: , Vol. 7, No. 1, 03.2013, p. 54-59.
- "Salicylate-independent lesion formation in Arabidopsis lsd mutants." Molecular Plant-Microbe Interactions In: , Vol. 10, No. 5, 07.1997, p. 531-536.
- "The arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor IκB." Plant Cell In: , Vol. 9, No. 3, 03.1997, p. 425-439.
- "Recent advances in systemic acquired resistance research - A review." Gene In: , Vol. 179, No. 1, 07.11.1996, p. 89-95.
- "Benzothiadiazole induces disease resistance in Arabidopsis by activation of the systemic acquired resistance signal transduction pathway." Plant Journal In: , Vol. 10, No. 1, 07.1996, p. 71-82.
- "Reduction of risk for growers : Methods for the development of disease-resistant crops." New Phytologist In: , Vol. 133, No. 1, 1996, p. 3-10.
- "Resistance workers." Trends in Plant Science In: , Vol. 1, No. 9, 1996, p. 293-294.
- "Systemic acquired resistance in Arabidopsis requires salicylic acid but not ethylene." Molecular Plant-Microbe Interactions In: , Vol. 8, No. 6, 11.1995, p. 863-870.
- "Suppression and restoration of lesion formation in Arabidopsis Isd mutants." Plant Cell In: , Vol. 7, No. 12, 1995, p. 2013-2022.
- "Signal transduction in systemic acquired resistance." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 92, No. 10, 1995, p. 4202-4205.
- "A central role of salicylic acid in plant disease resistance." Science In: , Vol. 266, No. 5188, 1994, p. 1247-1250.
- "Isolation of transgenic progeny of maize by embryo rescue under selective conditions." In Vitro Cellular & Developmental Biology - Plant In: , Vol. 29, No. 1, 01.1993, p. 33-37.
- "Increased tolerance to two oomycete pathogens in transgenic tobacco expressing pathogenesis-related protein 1a." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 90, No. 15, 1993, p. 7327-7331.
- "Herbicide resistance due to amplification of a mutant acetohydroxyacid synthase gene." MGG Molecular & General Genetics In: , Vol. 233, No. 3, 06.1992, p. 427-435.