I am interested in understanding mechanisms of disrupted sleep and wakefulness associated with illness and injury, and the effects of these disruptions on recovery. My experiences as a nurse working with people following brain injury from stroke, trauma, and cancer who had persistent difficulties with fatigue, disrupted wakefulness, and disrupted sleep drive my interest to develop targeted therapies for these symptoms. I found that cytotoxic chemotherapy disrupts orexin neuropeptide signaling in the brain. This disruption was associated with decreased wakefulness and activity in rodents and replacing orexin restored activity. My current research is on the clinical side of translational research. I study disrupted sleep in Veterans, and the effect of previous traumatic brain injury, post-traumatic stress disorder, and sleep apnea on sleep, functional outcomes, and quality of life. My long term research goal is to improve recovery from brain injury by targeting sleep and wakefulness.
Areas of interest
- Disrupted wake-sleep; recovery from head injury; symptom management
- Ph.D., Oregon Health & Science University Oregon 2013
- B.S., University of California-Davis, Davis California 1985
- M.S., North Carolina State University North Carolina 1988
- B.S.N., Oregon Health & Science University Oregon 2007
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