Klaus Früh received his Ph.D. from the University of Heidelberg in 1990. From 1991 to 1994 he was a postdoctoral scientist at the Scripps Research Institute in La Jolla, California. In 1994 he joined the R.W. Johnson Pharmaceutical Research Institute, where he directed the antiviral pharmaceutical research program. In 2000 he joined the OHSU Vaccine and Gene Therapy Institute as associate professor and ONPRC as associate scientist, at the same time becoming director of the Microarray Shared Resource. He was promoted to Professor and Senior Scientist in 2005.
Dr. Früh is also co-founder and board member of VIR Biotechnology, a biotechnology company that harnesses the power of the immune system to prevent and treat infectious diseases.
Dr. Früh’s research focuses on understanding the molecular interaction between viral pathogens and their hosts, particularly the identification and characterization of viral gene products that modulate the innate and adaptive immune responses. This knowledge is translated into the development and improvement of cytomegalovirus (CMV)-vectored vaccines which are unique in their ability to persistently maintain an immune shield of so called effector memory T cells, including highly unconventional (MHC-II and MHC-E) restricted CD8+ T cells. CMV vectored vaccines have shown unprecedented protection in non-human primate models of AIDS and TB, and this novel vector concept is currently developed for both prophylactic and therapeutic vaccination against a number of chronic viral, bacterial and parasitic diseases as well as cancer.
Areas of interest
- Immune evasion
- Ph.D., University of Heidelberg, Heidelberg Germany 1990
- B.S., University of Konstanz, Konstanz Germany 1981
- B.Sc., University of Heidelberg, Heidelberg Germany 1985
Honors and awards
- Section Editor, PLOS Pathogens
- Editor, Journal of Virology
- Grant Reviews and Study sections: National Institute of Heath, USA; American Heart Association, USA; Council for Medical Research, Netherlands; Medical Research Council, UK;
- Grant Reviews and Study sections: Wellcome Trust, United Kingdom; Alberta Heritage Foundation, Canada; German Center for Infectious Diseases, Germany;
- Journal Reviewer: Science, PNAS, Immunity, PLoS Pathogens, EMBO J, J Exp Med, J Virol, Virology, J Gen Virol, J Immunol, Leukemia, J Inf Dis
- Journal Reviewer: Nature Genetics, Nature Reviews Microbiology, Nature Biotechnology, Trends in Microbiology
Memberships and associations
- American Association for the Advancement of Science; American Society for Microbiology; Deutsche Gesellschaft für Virologie
Cross-Species Rhesus Cytomegalovirus Infection of CynomolgusMacaques.