Photo of Kathleen A. Grant, Ph.D.

Kathleen A. Grant Ph.D.

  • (503) 346-5461
    • Professor Oregon National Primate Research Center
    • Professor of Behavioral Neuroscience School of Medicine
    • Chief, Division of Neuroscience Oregon National Primate Research Center
    • Behavioral Neuroscience Graduate Program School of Medicine

Kathleen (Kathy) Grant, Ph.D. is Chief and Professor, Division of Neuroscience at the Oregon National Primate Research Center. Her scientific interests are in animal models of addiction, particularly alcoholism.

Her studies in non human primates are aimed at understanding the co-morbidity of stress and excessive alcohol drinking examining risk factors such genetics, in utero exposure, adolescent vulnerability, sex differences and menstrual cycle effects, brain adaptations and cognitive impairments.

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Areas of interest

  • Animal models of alcohol and drug addiction
  • Stress response to chronic alcohol drinking
  • MRI imaging of brain circuitry
  • Advances in cognitive assessment of primate behavior
  • Behavioral pharmacology

Education

  • B.S., University of Santa Clara 1979
  • M.S., University of Washington 1982
  • Ph.D., University of Washington 1984
  • Fellowship:

    • National Research Service Award, University of Chicago, 1984-1987

Honors and awards

  • 2013 Henri Begleiter Excellence in Research Award, Research Society on Alcoholism
  • 2015 Master Lecture, 2015 American Psychological Association Convention
  • 2017 Plenary Lecture, 2017 Collaborative Perspectives on Addiction, Albuquerque, NM
  • 2016-2018 President, Behavioral Pharmacology Society (BPS)

Memberships and associations

  • 1992- Alcoholism: Clinical and Experimental Research; 2001-present: Reviewing Editor
  • 1995- Behavioral Pharmacology
  • 2013- Alcohol
  • RSA, ASPET, SFN, APA, ISBRA

Publications

  • "Concurrent gut transcriptome and microbiota profiling following chronic ethanol consumption in nonhuman primates." Gut Microbes  In: , 19.04.2018, p. 1-19.
  • "Synaptic adaptations to chronic ethanol intake in male rhesus monkey dorsal striatum depend on age of drinking onset." Neuropharmacology In: , Vol. 131, 15.03.2018, p. 128-142.
  • "Neuroactive Steroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) and Pro-inflammatory Cytokine MCP-1 Levels in Hippocampus CA1 are Correlated with Voluntary Ethanol Consumption in Cynomolgus Monkey." Alcoholism: Clinical and Experimental Research  In: , Vol. 42, No. 1, 01.01.2018, p. 12-20.
  • "Effect of repeated abstinence on chronic ethanol self-administration in the rhesus monkey." Psychopharmacology In: , 19.10.2017, p. 1-12.
  • "Orbitofrontal neuroadaptations and cross-species synaptic biomarkers in heavy-drinking macaques." Journal of Neuroscience In: , Vol. 37, No. 13, 29.03.2017, p. 3646-3660.
  • "Ranking cognitive flexibility in a group setting of rhesus monkeys with a set-shifting procedure." Frontiers in Behavioral Neuroscience In: , Vol. 11, 55, 23.03.2017.
  • "Social setting, social rank and HPA axis response in cynomolgus monkeys." Psychopharmacology In: , 22.03.2017, p. 1-9.
  • "First trimester alcohol exposure alters placental perfusion and fetal oxygen availability affecting fetal growth and development in a non-human primate model." American Journal of Obstetrics and Gynecology In: , Vol. 216, No. 3, 01.03.2017, p. 302.e1-302.e8.
  • "Studies using macaque monkeys to address excessive alcohol drinking and stress interactions." Neuropharmacology In: , 15.02.2017.
  • "Adaptations in basal and hypothalamic-pituitary-adrenal-activated deoxycorticosterone responses following ethanol self-administration in cynomolgus monkeys." Frontiers in Endocrinology In: , Vol. 8, No. FEB, 19, 06.02.2017.
  • "Alcohol-dose-dependent DNA methylation and expression in the nucleus accumbens identifies coordinated regulation of synaptic genes." Translational Psychiatry In: , Vol. 7, No. 1, 2016266, 01.01.2017.
  • "Identifying Future Drinkers : Behavioral Analysis of Monkeys Initiating Drinking to Intoxication is Predictive of Future Drinking Classification." Alcoholism: Clinical and Experimental Research In: , 2017.
  • "On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome." Addiction Biology  In: , 2017.
  • "Aggressive temperament predicts ethanol self-administration in late adolescent male and female rhesus macaques." Psychopharmacology In: , Vol. 233, No. 23-24, 01.12.2016, p. 3965-3976.
  • "Functional imaging of the nonhuman primate Placenta with endogenous blood oxygen level–dependent contrast." Magnetic Resonance in Medicine In: , Vol. 76, No. 5, 01.11.2016, p. 1551-1562.
  • "Genome-wide analysis of the nucleus accumbens identifies DNA methylation signals differentiating low/binge from heavy alcohol drinking." Alcohol  In: , 19.09.2016.
  • "Increased levels of the acetaldehyde-derived DNA adduct N-ethyldeoxyguanosine in oral mucosa DNA from Rhesus monkeys exposed to alcohol." Mutagenesis In: , Vol. 31, No. 5, 01.09.2016, p. 553-558.
  • "The Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala." Neuron In: , Vol. 91, No. 2, 20.07.2016, p. 453-466.
  • "Transcriptome profiling reveals disruption of innate immunity in chronic heavy ethanol consuming female rhesus macaques." PLoS One  In: , Vol. 11, No. 7, e0159295, 01.07.2016.
  • "Electrical coupling and synchronized subthreshold oscillations in the inferior olive of the Rhesus Macaque." Journal of Neuroscience In: , Vol. 36, No. 24, 15.06.2016, p. 6497-6502.
  • "Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques." Psychopharmacology In: , 19.02.2016, p. 1-9.
  • "Opposing effects of alcohol on the immune system." Progress in Neuro-Psychopharmacology and Biological Psychiatry  In: , Vol. 65, 04.02.2016, p. 242-251.
  • "Alcohol consumption modulates host defense in rhesus macaques by altering gene expression in circulating leukocytes." Journal of Immunology  In: , Vol. 196, No. 1, 01.01.2016, p. 182-195.
  • "Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core." Drug and Alcohol Dependence In: , Vol. 158, 01.01.2016, p. 159-163.
  • "Alcohol : A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton." Alcoholism: Clinical and Experimental Research In: , 2016.
  • "Brain pathways to recovery from alcohol dependence." Alcohol In: , Vol. 49, No. 5, 01.08.2015, p. 435-452.
  • "An ultrastructural analysis of the effects of ethanol self-administration on the hypothalamic paraventricular nucleus in rhesus macaques." Frontiers in Cellular Neuroscience In: , Vol. 9, No. JULY, 260, 14.07.2015.
  • "MAOA expression predicts vulnerability for alcohol use." Molecular Psychiatry In: , 07.07.2015.
  • "Nicotinic receptors in non-human primates : Analysis of genetic and functional conservation with humans." Neuropharmacology In: , Vol. 96, No. PB, 5737, 27.06.2015, p. 263-273.
  • "NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking." Nature Neuroscience In: , Vol. 18, No. 4, 28.04.2015, p. 545-552.

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