Photo of Julie A. Saugstad, Ph.D.

Julie A. Saugstad Ph.D.

  • (503) 494-4926
    • Associate Professor of Anesthesiology and Perioperative Medicine School of Medicine
    • Associate Professor of Molecular and Medical Genetics School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Research Interests: Cell/Molecular Neurobiology, Signal Transduction, MicroRNA Regulation of Gene Expression, Extracellular Vesicles, Alzheimer's Disease, Neuroprotection.

Education

  • Ph.D., University of Oklahoma Health Sciences Center, Oklahoma City Oklahoma United States 1991
  • Fellowship:

    • Postdoctoral Fellow, Vollum Institute, 1991-1996

Publications

  • "Author response : Comparison of MicroRNA expression in aqueous humour of normal and primary open-angle glaucoma patients using PCR arrays: A pilot study." Investigative Ophthalmology and Visual Science In: , Vol. 58, No. 12, 01.10.2017.
  • "Comparison of microRNA expression in aqueous humor of normal and primary open-angle glaucoma patients using PCR arrays : A pilot study." Investigative Ophthalmology and Visual Science In: , Vol. 58, No. 7, 01.06.2017, p. 2884-2890.
  • "Sex differences in regulatory cells in experimental stroke." Cellular Immunology  In: , 23.05.2017.
  • "MicroRNAs in human cerebrospinal fluid as biomarkers for Alzheimer's disease." Journal of Alzheimer's Disease In: , Vol. 55, No. 3, 2017, p. 1223-1233.
  • "Loss of PPARα perpetuates sex differences in stroke reflected by peripheral immune mechanisms." Metabolic Brain Disease  In: , 12.02.2016, p. 1-10.
  • "Role for microglia in sex differences after ischemic stroke : importance of M2." Metabolic Brain Disease  In: , Vol. 30, No. 6, 01.12.2015, p. 1515-1529.
  • "Sex differences and the role of PPAR alpha in experimental stroke." Metabolic Brain Disease  In: , 18.11.2015, p. 1-9.
  • "Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke." Journal of Neuroimmunology  In: , Vol. 278, 15.01.2015, p. 289-298.
  • "Regulatory CD8CD122 T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells." Metabolic Brain Disease  In: , Vol. 30, No. 4, A003, 2015, p. 911-924.
  • "PD-L1 monoclonal antibody treats ischemic stroke by controlling central nervous system inflammation." Stroke  In: , Vol. 46, No. 10, 2015, p. 2926-2934.
  • "Non-coding RNAs in stroke and neuroprotection." Frontiers in Neurology In: , Vol. 6, No. MAR, 050, 2015.
  • "Extracellular RNAs : Development as biomarkers of human disease." Journal of Extracellular Vesicles In: , Vol. 4, No. 1, 27495, 2015.
  • "MicroRNA responses to focal cerebral ischemia in male and female mouse brain." Frontiers in Molecular Neuroscience In: , Vol. 7, No. FEB, 11, 11.02.2014.
  • "Sex differences in microRNA expression during developmentin rat cortex." Neurochemistry International In: , Vol. 77, 2014, p. 24-32.
  • "Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function (Molecular Pharmacology (2002) 61 (1303-1312))." Molecular Pharmacology In: , Vol. 84, No. 6, 12.2013, p. 948.
  • "MicroRNAs as effectors of brain function." Stroke  In: , Vol. 44, No. SUPPL. 1, 01.2013.
  • "Effect of (S)-3,5-DHPG on microRNA expression in mouse brain." Experimental Neurology In: , Vol. 235, No. 2, 06.2012, p. 497-507.
  • "MiRNA expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132." American Journal of Pathology In: , Vol. 179, No. 5, 11.2011, p. 2519-2532.
  • "MicroRNAs : Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease." Pharmacology and Therapeutics  In: , Vol. 130, No. 1, 04.2011, p. 26-37.
  • "MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 30, No. 9, 09.2010, p. 1564-1576.
  • "Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 30, No. 4, 04.2010, p. 744-756.
  • "Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance." Science Signaling  In: , Vol. 3, No. 111, 02.03.2010.
  • "Ubiquitin-proteasome-mediated synaptic reorganization : A novel mechanism underlying rapid ischemic tolerance." Journal of Neuroscience  In: , Vol. 28, No. 1, 02.01.2008, p. 50-59.
  • "A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a." Journal of Biological Chemistry In: , Vol. 282, No. 31, 03.08.2007, p. 22668-22677.
  • "Rapid degradation of bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons." Journal of Biological Chemistry  In: , Vol. 281, No. 11, 17.03.2006, p. 7429-7436.
  • "ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents." Journal of Neuroscience  In: , Vol. 26, No. 20, 2006, p. 5329-5339.
  • "Identification and characterization of human cytomegalovirus-encoded microRNAs." Journal of Virology  In: , Vol. 79, No. 18, 09.2005, p. 12095-12099.
  • "NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin." Neuropharmacology  In: , Vol. 49, No. SUPPL., 2005, p. 135-145.
  • "Analysis of the membrane topology of the acid-sensing ion channel 2a." Journal of Biological Chemistry In: , Vol. 279, No. 53, 31.12.2004, p. 55514-55519.
  • "Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels." Journal of Neuroscience  In: , Vol. 24, No. 40, 06.10.2004, p. 8678-8689.

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