Photo of Jonah B. Sacha, Ph.D.

Jonah B. Sacha Ph.D.

  • (503) 418-2774
    • Associate Professor VGTI-Vaccine and Gene Therapy Institute
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Sacha graduated cum laude from the University of Missouri-Columbia in 2003 with a B.A. in German and B.S. in Biology.  After receiving his Ph.D. in Medical Microbiology & Immunology from the University of Wisconsin-Madison in 2007, he joined the faculty at UW-Madison where he researched the characteristics of effective retrovirus-specific CD8+ and CD4+ T cells.  In 2011, he joined the Oregon Health & Science University and has appointments in both the Vaccine & Gene Therapy Institute and Oregon National Primate Research Center.

Areas of interest

  • T cell Biology
  • Retroviruses
  • Vaccine development

Education

  • B.S., University of Missouri, Columbia Missouri United States 2003
  • Ph.D., University of Wisconsin, Madison Wisconsin United States 2007

Honors and awards

  • 2013 - Creative and Novel Ideas in HIV Research Award
  • 2011 - AIDS Vaccine Conference Scholarship Award
  • 2011 - Young Investigator Editor for AIDS Research & Human Retroviruses
  • 2008 - Nonhuman Primate Symposium Young Investigator Scholarship
  • 2008 - University of Wisconsin-Madison Vilas Travel Scholarship
  • 2007 - Keystone Symposia: HIV Vaccines Young Investigator Scholarship
  • 2003 - National Science Foundation REU Graduate Fellowship
  • 2003 - Bachelor of Science with Departmental Honors
  • 2003 - Bachelor of Science with Honors, cum laude
  • 2003 - Bachelor of Arts with Honors, cum laude
  • 1997 - Rotary International Youth Ambassador to Germany
  • 1997 - Bright Flight Undergraduate Scholarship (maintained all years at University of Missouri)

Memberships and associations

  • Member, American Society of Microbiology
  • Member, Society for Leukocyte Biology
  • Member, International AIDS Society
  • Member, American Society of Hematology

Publications

Selected publications

  • Ericsen AJ, Lauck M, Mohns MS, DiNapoli SR, Mutschler JP,Greene JM, Weinfurter JT, Lehrer-Brey G, Prall TM, Gieger SM, Buechler CR,Crosno KA, Peterson EJ, Reynolds MR, Wiseman RW, Burwitz BJ, Estes JD, SachaJB, Friedrich TC, Brenchley JM, O'Connor DH. Microbial Translocation andInflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication. PLoS Pathog. 2016 Dec7;12(12):e1006048. doi: 10.1371/journal.ppat.1006048. [PMID: 27926931]

  • Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB,Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A,Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ,Früh K, Sacha JB. Cross-Species Rhesus Cytomegalovirus Infection of CynomolgusMacaques. PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi:10.1371/journal.ppat.1006014. [PMID: 27829026]

  • Greene JM, Dash P, Roy S, McMurtrey C, Awad W, Reed JS,Hammond KB, Abdulhaqq S, Wu HL, Burwitz BJ, Roth BF, Morrow DW, Ford JC, Xu G,Bae JY, Crank H, Legasse AW, Dang TH, Greenaway HY, Kurniawan M, Gold MC,Harriff MJ, Lewinsohn DA, Park BS, Axthelm MK, Stanton JJ, Hansen SG, PickerLJ, Venturi V, Hildebrand W, Thomas PG, Lewinsohn DM, Adams EJ, Sacha JB. MR1-restrictedmucosal-associated invariant T (MAIT) cells respond to mycobacterialvaccination and infection in nonhuman primates. Mucosal Immunol. 2016 Oct 19.doi: 10.1038/mi.2016.91. [PMID: 27759023]

  • Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S,Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM,Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K.Natural KillerCell Evasion Is Essential for Infection by Rhesus Cytomegalovirus. PLoS Pathog.2016 Aug 31;12(8):e1005868. doi: 10.1371/journal.ppat.1005868. [PMID: 27580123]

  • Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, DaneshA, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T,Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK.Human Galectin-9 Is aPotent Mediator of HIV Transcription and Reactivation. PLoS Pathog. 2016 Jun2;12(6):e1005677. doi: 10.1371/journal.ppat.1005677. [PMID: 27253379]

Publications

  • "The Role of MHC-E in T Cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques." Journal of Immunology In: , Vol. 200, No. 1, 01.01.2018, p. 49-60.
  • "Combination adenovirus and protein vaccines prevent infection or reduce viral burden after heterologous clade C simian-human immunodeficiency virus mucosal challenge." Journal of Virology  In: , Vol. 92, No. 2, e01092-17, 01.01.2018.
  • "Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes." Nature Communications In: , Vol. 8, No. 1, 1418, 01.12.2017.
  • "Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques /631/326/596/1550 /631/326/596/2555 /631/326/596/2557 article." Nature Communications In: , Vol. 8, No. 1, 2146, 01.12.2017.
  • "Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers." Retrovirology  In: , Vol. 14, No. 1, 41, 22.08.2017.
  • "MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates." Mucosal Immunology In: , Vol. 10, No. 3, 01.05.2017, p. 802-813.
  • "Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication." PLoS Pathogens In: , Vol. 12, No. 12, e1006048, 07.12.2016.
  • "Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques." PLoS Pathogens In: , Vol. 12, No. 11, e1006014, 01.11.2016.
  • "Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus." PLoS Pathogens  In: , Vol. 12, No. 8, e1005868, 01.08.2016.
  • "Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation." PLoS Pathogens In: , Vol. 12, No. 6, e1005677, 01.06.2016.
  • "Achieving potent autologous neutralizing antibody responses against tier 2 HIV-1 viruses by strategic selection of envelope immunogens." Journal of Immunology In: , Vol. 196, No. 7, 01.04.2016, p. 3064-3078.
  • "Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques." Nature Medicine In: , Vol. 22, No. 4, 01.04.2016, p. 362-368.
  • "Strategies to target non-T-cell HIV reservoirs." Current Opinion in HIV and AIDS In: , 25.03.2016.
  • "Broadly targeted CD8 T cell responses restricted by major histocompatibility complex E." Science In: , Vol. 351, No. 6274, 12.02.2016, p. 714-720.
  • "Identification and spontaneous immune targeting of an endogenous retrovirus K envelope protein in the Indian rhesus macaque model of human disease." Retrovirology In: , 15.01.2016.
  • "Comparison of the superagonist complex, ALT-803, to IL15 as cancer immunotherapeutics in animal models." Cancer immunology research In: , Vol. 4, No. 1, 01.01.2016, p. 49-60.
  • "TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection." PLoS Pathogens In: , Vol. 12, No. 1, e1005349, 2016.
  • "Acute viral escape selectively impairs nef-mediated major histocompatibility complex class i downmodulation and increases susceptibility to antiviral t cells." Journal of Virology In: , Vol. 90, No. 4, 2016, p. 2119-2126.
  • "Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection." Journal of Virology  In: , Vol. 89, No. 15, 2015, p. 7521-7535.
  • "Expansion of dysfunctional Tim-3 - Expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques." Journal of Immunology In: , Vol. 193, No. 11, 01.12.2014, p. 5576-5583.
  • "Erratum : Immune clearance of highly pathogenic SIV infection (Nature (2013) 502 (100-104) DOI:10.1038/nature12519))." Nature In: , Vol. 514, No. 7524, 30.10.2014, p. 654.
  • "Cutting edge : An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells." Journal of Immunology In: , Vol. 193, No. 4, 15.08.2014, p. 1544-1548.
  • "Vaccination against endogenous retrotransposable element consensus sequences does not protect rhesus macaques from SIVsmE660 infection and replication." PLoS One In: , Vol. 9, No. 3, e92012, 20.03.2014.
  • "Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection." Retrovirology In: , Vol. 11, No. 1, 10, 28.01.2014.
  • "Technical advance : Liposomal alendronate depletes monocytes and macrophages in the nonhuman primate model of human disease." Journal of Leukocyte Biology In: , Vol. 96, No. 3, 2014, p. 491-501.
  • "Tertiary mutations stabilize CD8+ T lymphocyte escape-associated compensatory mutations following transmission of simian immunodeficiency virus." Journal of Virology In: , Vol. 88, No. 6, 2014, p. 3598-3604.
  • "T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence." PLoS Pathogens  In: , Vol. 10, No. 5, e1004123, 2014.
  • "T cells target APOBEC3 proteins in human immunodeficiency virus type 1-infected humans and simian immunodeficiency virus-infected indian rhesus macaques." Journal of Virology In: , Vol. 87, No. 11, 06.2013, p. 6073-6080.
  • "Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T Cells." Journal of Virology In: , Vol. 87, No. 5, 03.2013, p. 2628-2638.
  • "Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms." Science In: , Vol. 340, No. 6135, 1237874, 2013.

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