Photo of Jeffrey Kaye, M.D.

Jeffrey Kaye M.D.

    • Professor of Neurology School of Medicine
    • Layton Professor and Director Layton Aging and Alzheimer's Disease Center School of Medicine
    • Director ORCATECH School of Medicine
    • Layton Professor Biomedical Engineering School of Medicine
    • Biomedical Engineering Graduate Program School of Medicine

Dr. Jeffrey Kaye is the Layton professor of neurology and biomedical engineering and the director of the Layton Aging and Alzheimer's Disease Center, as well as director of the Oregon Center for Aging and Technology (ORCATECH) . Dr. Kaye received his medical degree from New York Medical College and trained in neurology at Boston University. He completed fellowships in Movement Disorders at Boston University and in brain aging at the National Institute on Aging.

He moved to Oregon in 1989 to develop the Layton Aging and Alzheimer's Disease Center. Dr. Kaye has received the Charles Dolan Hatfield Research Award for his work. He is listed in Best Doctors in America. He serves on many national and international panels and review boards in the field of geriatrics and neurology. He is an author on over 400 scientific publications and holds several major grant awards from federal agencies, national foundations and industrial sponsors.

Dr. Kaye serves as a member of the OHSU Healthy Aging Alliance Executive Committee.

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  • M.D., New York Medical College 1980
  • Fellowship:

    • Movement Disorders, Boston University
    • Brain Aging, National Institute on Aging


  • "Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states." Scientific Reports  In: , Vol. 8, No. 1, 4103, 01.12.2018.
  • "Day-to-day variability of postural sway and its association with cognitive function in older adults : A pilot study." Frontiers in Aging Neuroscience In: , Vol. 10, No. MAY, 126, 04.05.2018.
  • "MR imaging-based multimodal autoidentification of perivascular spaces (mMAPS) : Automated morphologic segmentation of enlarged perivascular spaces at clinical field strength." Radiology In: , Vol. 286, No. 2, 01.02.2018, p. 632-642.
  • "APOE DNA methylation is altered in Lewy body dementia." Alzheimer's and Dementia  In: , 01.01.2018.
  • "Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features." Scientific Reports  In: , Vol. 7, No. 1, 8137, 01.12.2017.
  • "Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty." Scientific Reports  In: , Vol. 7, No. 1, 14052, 01.12.2017.
  • "Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians." Psychopharmacology In: , 29.11.2017, p. 1-10.
  • "Dementia Care Comes Home : Patient and Caregiver Assessment via Telemedicine." Gerontologist  In: , Vol. 57, No. 5, 01.10.2017, p. e85-e93.
  • "Biometric monitoring devices for assessing end points in clinical trials : Developing an ecosystem." Nature Reviews Drug Discovery In: , Vol. 16, No. 10, 01.10.2017.
  • "The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease." Alzheimer's and Dementia: Translational Research and Clinical Interventions In: , Vol. 3, No. 3, 01.09.2017, p. 348-359.
  • "Internet searches and their relationship to cognitive function in older adults : Cross-sectional analysis." Journal of Medical Internet Research  In: , Vol. 19, No. 9, e307, 01.09.2017.
  • "Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease." Nature Genetics In: , Vol. 49, No. 9, 01.09.2017, p. 1373-1384.
  • "Transethnic genome-wide scan identifies novel Alzheimer's disease loci." Alzheimer's and Dementia  In: , Vol. 13, No. 7, 01.07.2017, p. 727-738.
  • "Predicting mild cognitive impairment from spontaneous spoken utterances." Alzheimer's and Dementia: Translational Research and Clinical Interventions  In: , Vol. 3, No. 2, 01.06.2017, p. 219-228.
  • "Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease." JAMA Neurology  In: , Vol. 74, No. 5, 01.05.2017, p. 557-566.
  • "Recommended cognitive outcomes in preclinical Alzheimer's disease : Consensus statement from the European Prevention of Alzheimer's Dementia project." Alzheimer's and Dementia In: , Vol. 13, No. 2, 01.02.2017, p. 186-195.
  • "Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease." Scientific Reports  In: , Vol. 7, 39880, 12.01.2017.
  • "Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies : a retrospective analysis." The Lancet Neurology In: , Vol. 16, No. 1, 01.01.2017, p. 1234.
  • "Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains." JAMA Neurology In: , Vol. 74, No. 1, 01.01.2017, p. 91-99.
  • "Variability in medication taking is associated with cognitive performance in nondemented older adults." Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring  In: , Vol. 6, 2017, p. 210-213.
  • "Serum hepcidin levels, iron dyshomeostasis and cognitive loss in Alzheimer'S Disease." Aging and Disease  In: , Vol. 8, No. 2, 2017, p. 215-227.
  • "Passive assessment of routine driving with unobtrusive sensors : A new approach for identifying and monitoring functional level in normal aging and mild cognitive impairment." Journal of Alzheimer's Disease  In: , Vol. 59, No. 4, 2017, p. 1427-1437.
  • "Weekly observations of online survey metadata obtained through home computer use allow for detection of changes in everyday cognition before transition to mild cognitive impairment." Alzheimer's and Dementia  In: , 2017.
  • "Performance-based and observational assessments in clinical trials across the alzheimer’s disease spectrum." Innovations in Clinical Neuroscience  In: , Vol. 14, No. 1-2, 2017, p. 30-39.
  • "Comparison of cerebral blood flow and structural penumbras in relation to white matter hyperintensities : A multi-modal magnetic resonance imaging study." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 36, No. 9, 01.09.2016, p. 1528-1536.
  • "Longitudinal Relationship between Loneliness and Social Isolation in Older Adults : Results from the Cardiovascular Health Study." Journal of Aging and Health  In: , Vol. 28, No. 5, 01.08.2016, p. 775-795.
  • "Continuous Monitoring of Turning Mobility and Its Association to Falls and Cognitive Function : A Pilot Study." Journals of Gerontology - Series A Biological Sciences and Medical Sciences In: , Vol. 71, No. 8, 01.08.2016, p. 1102-1108.
  • "Gait velocity estimation using time-interleaved between consecutive passive IR Sensor Activations." IEEE Sensors Journal  In: , Vol. 16, No. 16, 7486123, 01.08.2016, p. 6351-6358.
  • "Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis." Nature Communications In: , Vol. 7, 11934, 21.06.2016.
  • "Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults." JAMA Neurology  In: , Vol. 73, No. 6, 01.06.2016, p. 721-732.

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