Photo of Jeffrey Kaye, M.D.

Jeffrey Kaye M.D.

    • Professor of Neurology School of Medicine
    • Layton Professor and Director Layton Aging and Alzheimer's Disease Center School of Medicine
    • Director ORCATECH School of Medicine
    • Layton Professor Biomedical Engineering School of Medicine
    • Biomedical Engineering Graduate Program School of Medicine

Dr. Jeffrey Kaye is the Layton professor of neurology and biomedical engineering and the director of the Layton Aging and Alzheimer's Disease Center, as well as director of the Oregon Center for Aging and Technology (ORCATECH) . Dr. Kaye received his medical degree from New York Medical College and trained in neurology at Boston University. He completed fellowships in Movement Disorders at Boston University and in brain aging at the National Institute on Aging.

He moved to Oregon in 1989 to develop the Layton Aging and Alzheimer's Disease Center. Dr. Kaye has received the Charles Dolan Hatfield Research Award for his work. He is listed in Best Doctors in America. He serves on many national and international panels and review boards in the field of geriatrics and neurology. He is an author on over 400 scientific publications and holds several major grant awards from federal agencies, national foundations and industrial sponsors.

Dr. Kaye serves as a member of the OHSU Healthy Aging Alliance Executive Committee.

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  • M.D., New York Medical College 1910
  • Fellowship:

    • Movement Disorders, Boston University
    • Brain Aging, National Institute on Aging


  • "The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease." Alzheimer's and Dementia: Translational Research and Clinical Interventions In: , Vol. 3, No. 3, 01.09.2017, p. 348-359.
  • "Predicting mild cognitive impairment from spontaneous spoken utterances." Alzheimer's and Dementia: Translational Research and Clinical Interventions  In: , Vol. 3, No. 2, 01.06.2017, p. 219-228.
  • "Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease." JAMA Neurology  In: , Vol. 74, No. 5, 01.05.2017, p. 557-566.
  • "Recommended cognitive outcomes in preclinical Alzheimer's disease : Consensus statement from the European Prevention of Alzheimer's Dementia project." Alzheimer's and Dementia In: , Vol. 13, No. 2, 01.02.2017, p. 186-195.
  • "Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease." Scientific Reports  In: , Vol. 7, 39880, 12.01.2017.
  • "Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies : a retrospective analysis." The Lancet Neurology In: , Vol. 16, No. 1, 01.01.2017, p. 1234.
  • "Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains." JAMA Neurology In: , Vol. 74, No. 1, 01.01.2017, p. 91-99.
  • "Variability in medication taking is associated with cognitive performance in nondemented older adults." Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring  In: , Vol. 6, 2017, p. 210-213.
  • "Serum hepcidin levels, iron dyshomeostasis and cognitive loss in Alzheimer'S Disease." Aging and Disease  In: , Vol. 8, No. 2, 2017, p. 215-227.
  • "Passive assessment of routine driving with unobtrusive sensors : A new approach for identifying and monitoring functional level in normal aging and mild cognitive impairment." Journal of Alzheimer's Disease  In: , Vol. 59, No. 4, 2017, p. 1427-1437.
  • "Comparison of cerebral blood flow and structural penumbras in relation to white matter hyperintensities : A multi-modal magnetic resonance imaging study." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 36, No. 9, 01.09.2016, p. 1528-1536.
  • "Longitudinal Relationship between Loneliness and Social Isolation in Older Adults : Results from the Cardiovascular Health Study." Journal of Aging and Health  In: , Vol. 28, No. 5, 01.08.2016, p. 775-795.
  • "Continuous Monitoring of Turning Mobility and Its Association to Falls and Cognitive Function : A Pilot Study." Journals of Gerontology - Series A Biological Sciences and Medical Sciences In: , Vol. 71, No. 8, 01.08.2016, p. 1102-1108.
  • "Gait velocity estimation using time-interleaved between consecutive passive IR Sensor Activations." IEEE Sensors Journal  In: , Vol. 16, No. 16, 7486123, 01.08.2016, p. 6351-6358.
  • "Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis." Nature Communications In: , Vol. 7, 11934, 21.06.2016.
  • "Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults." JAMA Neurology  In: , Vol. 73, No. 6, 01.06.2016, p. 721-732.
  • "Less Daily Computer Use is Related to Smaller Hippocampal Volumes in Cognitively Intact Elderly." Journal of Alzheimer's Disease In: , Vol. 52, No. 2, 10.05.2016, p. 713-717.
  • "Assessment of the genetic variance of late-onset Alzheimer's disease." Neurobiology of Aging  In: , Vol. 41, 01.05.2016, p. 200.e13-200.e20.
  • "ICC-dementia (International Centenarian Consortium - dementia) : An international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups." BMC Neurology In: , Vol. 16, No. 1, 52, 21.04.2016.
  • "Alzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci." PLoS One  In: , Vol. 11, No. 2, e0148717, 01.02.2016.
  • "Information and communication technology solutions for outdoor navigation in dementia." Alzheimer's and Dementia In: , 2016.
  • "Embedded Online Questionnaire Measures Are Sensitive to Identifying Mild Cognitive Impairment." Alzheimer Disease and Associated Disorders In: , Vol. 30, No. 2, 2016, p. 152-159.
  • "A Smart-Home System to Unobtrusively and Continuously Assess Loneliness in Older Adults." IEEE Journal of Translational Engineering in Health and Medicine  In: , Vol. 4, 7488979, 2016.
  • "Clustering home activity distributions for automatic detection of mild cognitive impairment in older adults ." Journal of Ambient Intelligence and Smart Environments  In: , Vol. 8, No. 4, 2016, p. 437-451.
  • "Detecting cognitive changes in preclinical Alzheimer's disease : A review of its feasibility." Alzheimer's and Dementia  In: , 2016.
  • "Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease." Alzheimer's and Dementia In: , 2016.
  • "Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples : Mendelian randomization analyses." Alzheimer's and Dementia  In: , Vol. 11, No. 12, 01.12.2015, p. 1439-1451.
  • "Association of long runs of homozygosity with Alzheimer disease among African American individuals." JAMA Neurology  In: , Vol. 72, No. 11, 01.11.2015, p. 1313-1323.
  • "Web-enabled conversational interactions as a method to improve cognitive functions : Results of a 6-week randomized controlled trial." Alzheimer's and Dementia: Translational Research and Clinical Interventions In: , Vol. 1, No. 1, 14.10.2015, p. 1-12.
  • "Time out-of-home and cognitive, physical, and emotional wellbeing of older adults : A longitudinal mixed effects model." PLoS One  In: , Vol. 10, No. 10, e0139643, 05.10.2015.

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