Photo of James Maylie, Ph.D.

James Maylie Ph.D.

    • Professor of Obstetrics and Gynecology School of Medicine
    • Neuroscience Graduate Program School of Medicine

Dr. Maylie received his Ph.D. from UO Medical School (now OHSU) in 1977 in physiology and completed a post-doctoral fellowship with Dr. Martin Morad at University of Pennsylvania. He was an Associate Research Assistant in the Department of Physiology at Yale University for 5 years prior to relocating to OHSU. Dr. Maylie’s lab primary focus is in the field of neurobiology. He was trained in electrophysiology and Ca2+ imaging and has merged these techniques along with molecular techniques to study fundamental issues in neuroscience. With his collaborator, Dr. John Adelman in the Vollum Institute at OHSU, they have taken advantage of the explosion in the field of neurobiology that occurred in the 1980s and 1990s with the ability to clone and heterologously express functional ion channels and develop transgenic mice. Over the years Dr. Maylie’s laboratory has become truly multi-dimensional employing a wide repertoire of techniques to address fundamental issues in neuroscience.

Education

  • B.A., Willamette University, Salem Oregon 1969
  • Ph.D., University of Oregon Medical School 1977
  • B.S., Stanford University 1971
  • Fellowship:

    • Postdoctoral fellow with Dr. Martin Morad, Department of Physiology, University of Pennsylvania, 1980

Publications

  • "Functional changes in hippocampal synaptic signaling in offspring survivors of a mouse model of intrauterine inflammation." Journal of Neuroinflammation  In: , Vol. 14, No. 1, 180, 05.09.2017.
  • "Assessment of mutations in KCNN2 and ZNF135 to patient neurological symptoms." NeuroReport In: , Vol. 28, No. 7, 2017, p. 375-379.
  • "Endothelial SK3 channel-associated ca microdomains modulate blood pressure." American Journal of Physiology - Heart and Circulatory Physiology In: , Vol. 310, No. 9, 01.05.2016, p. H1151-H1163.
  • "Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function." eLife In: , Vol. 5, No. FEBRUARY2016, e12637, 12.02.2016.
  • "IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons." eLife In: , Vol. 5, No. JANUARY2016, e11206, 14.01.2016.
  • "Apamin boosting of synaptic potentials in Ca2.3 R-type Ca channel null mice." PLoS One  In: , Vol. 10, No. 9, e0139332, 29.09.2015.
  • "Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation." European Journal of Neuroscience In: , Vol. 40, No. 8, 01.10.2014, p. 3179-3188.
  • "Distinct Ca2+ sources in dendritic spines of hippocampal CA1 Neurons Couple to SK and Kv4 Channels." Neuron  In: , Vol. 81, No. 2, 22.01.2014, p. 379-387.
  • "Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses." Journal of Neuroscience  In: , Vol. 33, No. 41, 2013, p. 16158-16169.
  • "SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons." Neuroscience In: , Vol. 217, 16.08.2012, p. 67-76.
  • "Modulation of endothelial SK3 channel activity by Ca2+-dependent caveolar trafficking." American Journal of Physiology - Cell Physiology  In: , Vol. 303, No. 3, 01.08.2012, p. 318-327.
  • "Developmental profile of SK2 channel expression and function in CA1 neurons." Hippocampus  In: , Vol. 22, No. 6, 06.2012, p. 1467-1480.
  • "Small-conductance Ca 2+-activated K + channels : Form and function." Annual Review of Physiology  In: , Vol. 74, 2012, p. 245-269.
  • "SK2 channels are neuroprotective for ischemia-induced neuronal cell death." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 31, No. 12, 12.2011, p. 2302-2312.
  • "The SK2-long isoform directs synaptic localization and function of SK2-containing channels." Nature Neuroscience In: , Vol. 14, No. 6, 06.2011, p. 744-749.
  • "Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons." Journal of Neuroscience  In: , Vol. 31, No. 7, 16.02.2011, p. 2638-2648.
  • "Cholinergic Signaling through Synaptic SK Channels : It's a Protein Kinase but Which One?" Neuron In: , Vol. 68, No. 5, 09.12.2010, p. 809-811.
  • "Coupled activity-dependent trafficking of synaptic SK2 channels and AMPA receptors." Journal of Neuroscience In: , Vol. 30, No. 35, 01.09.2010, p. 11726-11734.
  • "New sites of action for GIRK and SK channels." Nature Reviews Neuroscience In: , Vol. 10, No. 7, 07.2009, p. 475-480.
  • "SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses." Nature Neuroscience  In: , Vol. 11, No. 2, 02.2008, p. 170-177.
  • "Evidence for a deep pore activation gate in small conductance Ca 2+-activated K+ channels." Journal of General Physiology  In: , Vol. 130, No. 6, 12.2007, p. 601-610.
  • "Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice." Autonomic Neuroscience: Basic and Clinical  In: , Vol. 136, No. 1-2, 30.10.2007, p. 82-89.
  • "Organization and regulation of small conductance Ca2+-activated K+ channel multiprotein complexes." Journal of Neuroscience In: , Vol. 27, No. 9, 28.02.2007, p. 2369-2376.
  • "Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity." Journal of Neuroscience In: , Vol. 26, No. 6, 08.02.2006, p. 1844-1853.
  • "Erratum : Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity (Journal of Neuroscience (February 8, 2006) (1844-1853))." Journal of Neuroscience In: , Vol. 26, No. 17, 2006, p. 4714.
  • "A novel isoform of SK2 assembles with other SK subunits in mouse brain." Journal of Biological Chemistry In: , Vol. 280, No. 22, 03.06.2005, p. 21231-21236.
  • "SK channels in excitability, pacemaking and synaptic integration." Current Opinion in Neurobiology In: , Vol. 15, No. 3 SPEC. ISS., 06.2005, p. 305-311.
  • "SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines." Nature Neuroscience In: , Vol. 8, No. 5, 05.2005, p. 642-649.
  • "Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents." Journal of Neuroscience In: , Vol. 24, No. 23, 09.06.2004, p. 5301-5306.
  • "Activation kinetics of the slow afterhyperpolarization in hippocampal CA1 neurons." Pflugers Archiv European Journal of Physiology In: , Vol. 448, No. 2, 05.2004, p. 187-196.

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