Photo of Jacob Raber, Ph.D.

Jacob Raber Ph.D.

  • (503) 494-1524
    • Professor of Behavioral Neuroscience School of Medicine
    • Behavioral Neuroscience Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine

Our research focuses on effects of genetic factors, such as apoE, and environmental factors on brain structure and function in experimental mouse models of human neurological diseases. Based on what we learn in the mouse models, we try to develop tests and treatment strategies to improve brain function in humans suffering from these diseases. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches.    We developed humanized versions of the mouse object recognition and spatial navigation tests and assess whether they are sensitive to detect effects of sex and apoE4 on cognition in health and disease. These tests might be valuable in identifying biomarkers of cognitive function and susceptibility to cognitive impairments. 

Publications

  • "Si total body irradiation injures bone marrow hematopoietic stem cells via induction of cellular apoptosis." Life Sciences in Space Research  In: , Vol. 13, 01.05.2017, p. 39-44.
  • "Effects of adolescent methamphetamine and nicotine exposure on behavioral performance and MAP-2 immunoreactivity in the nucleus accumbens of adolescent mice." Behavioural Brain Research In: , Vol. 323, 14.04.2017, p. 78-85.
  • "CD44 transmembrane receptor and hyaluronan regulate adult hippocampal neural stem cell quiescence and differentiation." Journal of Biological Chemistry In: , Vol. 292, No. 11, 17.03.2017, p. 4434-4445.
  • "Genetic inhibition of Anaplastic Lymphoma Kinase rescues cognitive impairments in Neurofibromatosis 1 mutant mice." Behavioural Brain Research  In: , Vol. 321, 15.03.2017, p. 148-156.
  • "Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome." Scientific Reports  In: , Vol. 7, 43701, 08.03.2017.
  • "Enhanced cued fear memory following post-training whole body irradiation of 3-month-old mice." Behavioural Brain Research  In: , Vol. 319, 15.02.2017, p. 181-187.
  • "Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model." Oncotarget  In: , Vol. 8, No. 6, 2017, p. 9155-9173.
  • "Sex biology contributions to vulnerability to Alzheimer's disease : A think tank convened by the Women's Alzheimer's Research Initiative." Alzheimer's and Dementia In: , Vol. 12, No. 11, 01.11.2016, p. 1186-1196.
  • "Short- and long-term effects of Fe irradiation on cognition and hippocampal DNA methylation and gene expression." BMC Genomics  In: , Vol. 17, No. 1, 825, 24.10.2016.
  • "Densely ionizing radiation affects DNA methylation of selective LINE-1 elements." Environmental Research  In: , Vol. 150, 01.10.2016, p. 470-481.
  • "Mitigating effect of EUK-207 on radiation-induced cognitive impairments." Behavioural Brain Research In: , 14.09.2016.
  • "Genotype differences in anxiety and fear learning and memory of WT and ApoE4 mice associated with enhanced generation of hippocampal reactive oxygen species." Journal of Neurochemistry  In: , 01.09.2016, p. 896-908.
  • "Effects of alcohol on c-Myc protein in the brain." Behavioural Brain Research  In: , 01.08.2016.
  • "High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 36, No. 7, 01.07.2016, p. 1257-1270.
  • "Metabolic shifts toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4." International Journal of Obesity In: , 07.06.2016.
  • "Ion mobility-enhanced MS-based label-free analysis reveals effects of low-dose radiation post contextual fear conditioning training on the mouse hippocampal proteome." Journal of Proteomics In: , Vol. 140, 17.05.2016, p. 24-36.
  • "Effect of behavioral testing on spine density of basal dendrites in the CA1 region of the hippocampus modulated by Fe irradiation." Behavioural Brain Research In: , Vol. 302, 01.04.2016, p. 263-268.
  • "Chronic methamphetamine exposure prior to middle cerebral artery occlusion increases infarct volume and worsens cognitive injury in Male mice." Metabolic Brain Disease  In: , 28.03.2016, p. 1-7.
  • "Fetal domoic acid exposure affects lateral amygdala neurons, diminishes social investigation and alters sensory-motor gating." NeuroToxicology In: , Vol. 53, 01.03.2016, p. 132-140.
  • "Post-training gamma irradiation-enhanced contextual fear memory associated with reduced neuronal activation of the infralimbic cortex." Behavioural Brain Research  In: , Vol. 298, 01.02.2016, p. 1-11.
  • "Immediate and lasting effects of chronic daily methamphetamine exposure on activation of cells in hypothalamic-pituitary-adrenal axis-associated brain regions." Psychopharmacology  In: , Vol. 233, No. 3, 01.02.2016, p. 381-392.
  • "Effects of Proton and Combined Proton and Fe Radiation on the Hippocampus." Radiation Research In: , Vol. 185, No. 1, 01.01.2016, p. 20-30.
  • "Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma." EBioMedicine  In: , Vol. 3, 01.01.2016, p. 26-42.
  • "Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus." BMC Genomics  In: , Vol. 17, No. 1, 273, 2016.
  • "Sex- and dose-dependent effects of calcium ion irradiation on behavioral performance of B6D2F1 mice during contextual fear conditioning training." Life Sciences in Space Research In: , 12.12.2015.
  • "Fe Irradiation Alters Spine Density and Dendritic Complexity in the Mouse Hippocampus." Radiation Research In: , Vol. 184, No. 6, 01.12.2015, p. 586-594.
  • "Combined exposure to protons and Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung." Life Sciences in Space Research  In: , Vol. 7, 01.11.2015, p. 1-8.
  • "Oxygen irradiation enhances cued fear memory in B6D2F1 mice." Life Sciences in Space Research In: , Vol. 7, 01.11.2015, p. 61-65.
  • "Sex, but not Apolipoprotein E Polymorphism, Differences in Spatial Performance in Young Adults." Archives of Sexual Behavior In: , Vol. 44, No. 8, 01.11.2015, p. 2219-2226.
  • "Early gelatinase activity is not a determinant of long-term recovery after traumatic brain injury in the immature mouse." PLoS One  In: , Vol. 10, No. 11, e0143386, 01.11.2015.

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