Photo of Ines Koerner, M.D., PH.D.

Ines Koerner M.D., PH.D.

    • Associate Professor of Anesthesiology and Perioperative Medicine School of Medicine

Ines P. Koerner, M.D. Ph.D. is a neurointensivist and anesthesiologist with broad expertise in the treatment of critically ill patients with neurologic injuries. She earned her medical degree at Albert Ludwigs University in Freiburg, Germany and went on to complete doctoral studies in molecular neuroscience and a residency in anesthesiology and critical care at Johannes Gutenberg University in Mainz, Germany.

Dr. Koerner arrived at Oregon Health & Science University in 2003 for postdoctoral training, including a critical care fellowship, in the Department of Anesthesiology and Perioperative Medicine (APOM). She accepted a faculty position in 2007 and joined the Neurosciences Intensive Care Unit (NSICU) as an attending physician. Dr. Koerner is currently the Medical Director for the NSICU.

As a certified neurocritical care specialist, Dr. Koerner cares for patients who recover from neurosurgical interventions in the NSICU or are critically ill with a wide variety of neurologic diseases and injuries. She is particularly interested in multidisciplinary treatment of critical illness caused by ischemic or hemorrhagic stroke. Dr. Koerner maintains an active research lab where she studies how the immune system’s response contributes to damage after stroke and other types of brain injury. She received research funding from the National Institute for Neurologic Diseases and Stroke (NINDS) and the American Heart Association for her investigation of how altering the brain’s immune response can reduce injury and improve outcome after stroke and cardiac arrest.

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Education

  • M.D., Albert-Ludwigs-University, Freiburg Germany 1997
  • Ph.D., Johannes Gutenberg-University, Mainz Germany 2002
  • Residency:

    • Johannes Gutenberg-University Mainz, Germany
  • Fellowship:

    • Post-doctoral research fellowship, Oregon Health & Science University, Portland
  • Certifications:

    • German Board of Anesthesiology and Critical Care

Memberships and associations

  • Memberships and Associations

Publications

  • "Perioperative Management of Adult Patients With External Ventricular and Lumbar Drains : Guidelines From the Society for Neuroscience in Anesthesiology and Critical Care." Journal of Neurosurgical Anesthesiology  In: , 06.02.2017.
  • "St. John : Not such a saint: Fatal Forty DDI: St. John's wort, cyclosporine, CYP3A4, P-glycoprotein."  A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. p. 969-971.
  • "An interaction with the furniture : Fatal forty DDI: Warfarin, metronidazole, ciprofl oxacin, CYP2C9, CYP1A2."  A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. p. 661-664.
  • "Peroxisomal translocation of soluble epoxide hydrolase protects against ischemic stroke injury." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 35, No. 9, 03.09.2015, p. 1416-1420.
  • "Extracranial hypothermia during cardiac arrest and cardiopulmonary resuscitation is neuroprotective in vivo." Therapeutic hypothermia and temperature management In: , Vol. 4, No. 2, 01.06.2014, p. 79-87.
  • "Inhibition of soluble epoxide hydrolase after cardiac arrest/ cardiopulmonary resuscitation induces a neuroprotective phenotype in activated microglia and improves neuronal survival." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 33, No. 10, 10.2013, p. 1574-1581.
  • "Mechanism of the sex difference in neuronal ischemic cell death." Neuroscience In: , Vol. 219, 06.09.2012, p. 183-191.
  • "Microglia in ischemic brain injury." Future Neurology  In: , Vol. 5, No. 2, 03.2010, p. 227-246.
  • "Sex, sex steroids, and brain injury." Seminars in Reproductive Medicine In: , Vol. 27, No. 3, 05.2009, p. 229-239.
  • "Effects of gender and sex steroids on ischemic injury." Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn In: , Vol. 92, 2009, p. 149-169.
  • "Gender and the injured brain." Anesthesia and Analgesia In: , Vol. 107, No. 1, 07.2008, p. 201-214.
  • "Estrogen induces rapid translocation of estrogen receptor β, but not estrogen receptor α, to the neuronal plasma membrane." Neuroscience In: , Vol. 153, No. 3, 15.05.2008, p. 751-761.
  • "Chapter 8 Effects of gender and sex steroids on ischemic injury." Handbook of Clinical Neurology In: , Vol. 92, 2008, p. 149-169.
  • "Soluble epoxide hydrolase : Regulation by estrogen and role in the inflammatory response to cerebral ischemia." Frontiers in bioscience : a journal and virtual library In: , Vol. 13, No. 8, 2008, p. 2833-2841.
  • "Soluble epoxide hydrolase : A novel therapeutic target in stroke." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 27, No. 12, 12.2007, p. 1931-1940.
  • "Soluble epoxide hydrolase : Sex differences and role in estrogen-mediated neuroprotection." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 27, No. SUPPL. 1, 13.11.2007.
  • "Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury." Journal of Neuroscience In: , Vol. 27, No. 17, 25.04.2007, p. 4642-4649.
  • "Induction of cerebral ischemic tolerance by erythromycin preconditioning reprograms the transcriptional response to ischemia and suppresses inflammation." Anesthesiology In: , Vol. 106, No. 3, 03.2007, p. 538-547.
  • "Parkinson's Disease (PD)."  Decision Making in Anesthesiology. Elsevier Inc., 2007. p. 178-179.
  • "Gender, sex steroids, and cerebral ischemic pathobiology."  Handbook of Neurochemistry and Molecular Neurobiology: Acute Ischemic Injury and Repair in the Nervous System. Springer US, 2007. p. 185-207.
  • "Brain protection by anesthetic agents." Current Opinion in Anaesthesiology In: , Vol. 19, No. 5, 10.2006, p. 481-486.
  • "Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 103, No. 39, 26.09.2006, p. 14489-14494.
  • "An early bolus of hypertonic saline hydroxyethyl starch improves long-term outcome after global cerebral ischemia." Critical Care Medicine  In: , Vol. 34, No. 8, 08.2006, p. 2194-2200.
  • "The antibiotic erythromycin induces tolerance against transient global cerebral ischemia in rats (pharmacologic preconditioning)." Anesthesiology  In: , Vol. 104, No. 6, 06.2006, p. 1208-1215.
  • "Fiberoptic techniques." Best Practice and Research: Clinical Anaesthesiology In: , Vol. 19, No. 4, 12.2005, p. 611-621.
  • "Prehospital advanced trauma life support : How should we manage the airway, and who should do it?" Critical Care In: , Vol. 8, No. 1, 02.2004, p. 3-5.
  • "Tolerance-inducing dose of 3-nitropropionic acid modulates bcl-2 and bax balance in the rat brain : A potential mechanism of chemical preconditioning." Journal of Cerebral Blood Flow and Metabolism  In: , Vol. 20, No. 10, 2000, p. 1425-1436.

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