Photo of Hiroyuki Nakai, M.D., Ph.D.

Hiroyuki Nakai M.D., Ph.D.

    • Professor of Molecular and Medical Genetics School of Medicine
    • Professor of Molecular Microbiology and Immunology School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Publications

  • "Site-directed RNA repair of endogenous Mecp2 RNA in neurons." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 114, No. 44, 31.10.2017, p. E9395-E9402.
  • "Adeno-associated virus (AAV) assembly-activating protein is not an essential requirement for capsid assembly of AAV serotypes 4, 5, and 11." Journal of Virology  In: , Vol. 91, No. 3, e01980-16, 2017.
  • "Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility : An update." Reproduction in Domestic Animals  In: , 2016.
  • "Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein." Journal of Virology  In: , Vol. 89, No. 6, 2015, p. 3038-3048.
  • "Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing." Nature Communications  In: , Vol. 5, 3075, 17.01.2014.
  • "An Experimental and Computational Evolution-Based Method to Study a Mode of Co-evolution of Overlapping Open Reading Frames in the AAV2 Viral Genome." PLoS One  In: , Vol. 8, No. 6, e66211, 24.06.2013.
  • "Intraganglionic AAV6 Results in Efficient and Long-Term Gene Transfer to Peripheral Sensory Nervous System in Adult Rats." PLoS One In: , Vol. 8, No. 4, e61266, 16.04.2013.
  • "Adeno-associated virus serotype 8 (AAV8) delivery of recombinant A20 to skeletal muscle reduces pathological Activation of Nuclear Factor (NF)-κB in muscle of mdx mice." Molecular Medicine In: , Vol. 18, No. 12, 06.11.2012, p. 1527-1535.
  • "AAV vectors containing rDNA homology display increased chromosomal integration and transgene persistence." Molecular Therapy  In: , Vol. 20, No. 10, 10.2012, p. 1902-1911.
  • "Direct injection into the dorsal root ganglion : Technical, behavioral, and histological observations." Journal of Neuroscience Methods  In: , Vol. 199, No. 1, 15.07.2011, p. 43-55.
  • "A potential role of distinctively delayed blood clearance of recombinant adeno-associated virus serotype 9 in robust cardiac transduction." Molecular Therapy  In: , Vol. 19, No. 6, 06.2011, p. 1079-1089.
  • "Erratum : A new recombinant adeno-associated virus (AAV)-based random peptide display library system: Infection-defective AAV1.9-3 as a novel detargeted platform for vector evolution (Gene Therapy and Regulation (2010) 5 (31-55) DOI: 10.1142/S1568558610000197)." Gene Therapy and Regulation  In: , Vol. 6, No. 1, 03.2011, p. 75.
  • "A new recombinant adeno-associated virus (AAV)-based random peptide display library system : Infection-defective AAV1.9-3 as a novel detargeted platform for vector evolution." Gene Therapy and Regulation  In: , Vol. 5, No. 1, 10.2010, p. 31-55.
  • "Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity." Gene Therapy In: , Vol. 17, No. 9, 09.2010, p. 1181-1190.
  • "Characterization of genome integrity for oversized recombinant AAV vector." Molecular Therapy  In: , Vol. 18, No. 1, 01.2010, p. 87-92.
  • "Rapidly evolving adeno-associated virus vectors : Increasing possibility of gene therapy with custom-made vectors." Drug Delivery System  In: , Vol. 24, No. 6, 2009, p. 582-591.
  • "Frequency and spectrum of genomic integration of recombinant adeno-associated virus serotype 8 vector in neonatal mouse liver." Journal of Virology  In: , Vol. 82, No. 19, 10.2008, p. 9513-9524.
  • "Recombinant adeno-associated virus type 8-mediated extensive therapeutic gene delivery into skeletal muscle of α-sarcoglycan-deficient mice." Human Gene Therapy  In: , Vol. 19, No. 7, 01.07.2008, p. 719-730.
  • "Efficient and Durable Gene Transfer to Transplanted Heart Using Adeno-associated Virus 9 Vector." Journal of Heart and Lung Transplantation  In: , Vol. 27, No. 5, 05.2008, p. 554-560.
  • "The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver." Molecular Therapy In: , Vol. 16, No. 5, 05.2008, p. 931-941.
  • "Simulation analysis of intracellular Na+ and Cl- homeostasis during β1-adrenergic stimulation of cardiac myocyte." Progress in Biophysics and Molecular Biology  In: , Vol. 96, No. 1-3, 01.2008, p. 171-186.
  • "The role of DNA-PKcs and artemis in opening viral DNA hairpin termini in various tissues in mice." Journal of Virology  In: , Vol. 81, No. 20, 10.2007, p. 11304-11321.
  • "DNA palindromes with a modest arm length of ≳20 base pairs are a significant target for recombinant adeno-associated virus vector integration in the liver, muscles, and heart in mice." Journal of Virology  In: , Vol. 81, No. 20, 10.2007, p. 11290-11303.
  • "Robust systemic transduction with AAV9 vectors in mice : efficient global cardiac gene transfer superior to that of AAV8." Molecular Therapy  In: , Vol. 14, No. 1, 07.2006, p. 45-53.
  • "Erratum : Successful transduction of liver in hemophilia by AAV- factor IX and limitations imposed by the host immune response (Nature Medicine (2006) 12 (342-347))." Nature Medicine In: , Vol. 12, No. 5, 05.2006, p. 592.
  • "Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response." Nature Medicine In: , Vol. 12, No. 3, 03.2006, p. 342-347.
  • "Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype." Journal of Virology In: , Vol. 80, No. 1, 01.2006, p. 426-439.
  • "Modified infusion procedures affect recombinant adeno-associated virus vector type 2 transduction in the liver." Human Gene Therapy In: , Vol. 16, No. 3, 03.2005, p. 299-306.
  • "Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver." Journal of Virology In: , Vol. 79, No. 6, 03.2005, p. 3606-3614.
  • "Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice." Journal of Virology In: , Vol. 79, No. 1, 01.2005, p. 214-224.

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