Photo of Gary L. Westbrook, M.D.

Gary L. Westbrook M.D.

  •      (503) 494-5429
    • Professor Vollum Institute
    • Senior Scientist Vollum Institute
    • Rocky and Julie Dixon Professor of Neurology Neurology School of Medicine
    • Director Neuroscience Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Jungers Center for Neurosciences Research

Dr. Westbrook received clinical training in Internal Medicine and Neurology in Boston and St. Louis, and research training at the National Institutes of Health. He is senior scientist at the Vollum Institute and the Dixon Professor of Neurology at OHSU. His research interests are the mechanisms of synaptic transmission in the nervous system. Dr. Westbrook has been active in recruitment of faculty to the Jungers Center and in OHSU training activities in disease-oriented neuroscience research. He initiated the Neurobiology of Disease course in the graduate program and currently serves as the Director of the Neuroscience Graduate Program at OHSU.

Areas of interest

  • neurogenesis and hippocampal circuits
  • olfactory microcircuits
  • glutamate receptors
  • synaptic transmission
  • regeneration and repair

Education

  • M.D., Case Western Reserve University 1976

Honors and awards

  • Javits Neuroscience Investigator Award, NINDS, NIH (1993)
  • MERIT Award, NIMH, NIH (1997)
  • National Academy of Medicine (elected member, 2008)

Memberships and associations

  • Editor-In-Chief, Journal of Neuroscience (2003-2007)
  • Senior Editor, eLife (2015- )

Publications

  • "Epilepsy-specific citation classics revisited." Epilepsy Currents In: , Vol. 18, No. 2, 01.03.2018, p. 72-83.
  • "Trajectory analysis unveils Reelin’s role in the directed migration of granule cells in the dentate gyrus." Journal of Neuroscience  In: , Vol. 38, No. 1, 03.01.2018, p. 137-148.
  • "Distinct temporal filters in mitral cells and external tufted cells of the olfactory bulb." Journal of Physiology In: , Vol. 595, No. 19, 01.10.2017, p. 6349-6362.
  • "Short-term depression of sprouted mossy fiber synapses from adult-born granule cells." Journal of Neuroscience  In: , Vol. 37, No. 23, 07.06.2017, p. 5722-5735.
  • "Presynaptic gain control by endogenous cotransmission of dopamine and GABA in the olfactory bulb." Journal of Neurophysiology In: , Vol. 117, No. 3, 01.03.2017, p. 1163-1170.
  • "Modulating synaptic NMDA receptors." Neuropharmacology In: , Vol. 112, 01.01.2017, p. 29-33.
  • "Transcriptional Profiling of Newly Generated Dentate Granule Cells Using TU Tagging Reveals Pattern Shifts in Gene Expression during Circuit Integration." eNeuro In: , Vol. 3, No. 1, 01.01.2016.
  • "Parallel processing of afferent olfactory sensory information." Journal of Physiology In: , 2016.
  • "Early exposure to Aroclor 1254 in vivo disrupts the functional synaptic development of newborn hippocampal granule cells." European Journal of Neuroscience In: , 2016.
  • "Localized hypoxia within the subgranular zone determines the early survival of newborn hippocampal granule cells." eLife In: , Vol. 4, No. OCTOBER2015, e08722, 17.10.2015.
  • "Functional integration of adult-born hippocampal neurons after traumatic brain injury." eNeuro  In: , Vol. 2, No. 5, e0056-15.2015, 01.01.2015.
  • "The IGF-derived tripeptide Gly-Pro-Glu is a weak NMDA receptor agonist." Journal of Neurophysiology In: , Vol. 112, No. 6, 15.09.2014, p. 1241-1245.
  • "Fatty acids increase neuronal hypertrophy of Pten knockdown neurons." Frontiers in Molecular Neuroscience In: , Vol. 7, No. 1 APR, 30, 23.04.2014.
  • "Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons." Frontiers in Neuroscience In: , No. 8 APR, 71, 2014.
  • "Neurologic impairment following closed head injury predicts post-traumatic neurogenesis." Experimental Neurology In: , Vol. 261, 2014, p. 156-162.
  • "Dual-transmitter neurons : Functional implications of co-release and co-transmission." Current Opinion in Neurobiology In: , Vol. 29, 2014, p. 25-32.
  • "Hierarchical excitatory synaptic connectivity in mouse olfactory cortex." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 110, No. 40, 01.10.2013, p. 16193-16198.
  • "Triheteromeric NMDA receptors at hippocampal synapses." Journal of Neuroscience In: , Vol. 33, No. 21, 22.05.2013, p. 9150-9160.
  • "Neural injury alters proliferation and integration of adult-generated neurons in the dentate gyrus." Journal of Neuroscience In: , Vol. 33, No. 11, 13.03.2013, p. 4754-4767.
  • "Distinct modes of dopamine and GABA release in a dual transmitter neuron." Journal of Neuroscience In: , Vol. 33, No. 5, 30.01.2013, p. 1790-1796.
  • "Structural plasticity in the dentate gyrus- Revisiting a classic injury model." Frontiers in Neural Circuits In: , No. JAN, 27.01.2013.
  • "Neuroligin-1 Overexpression in Newborn Granule Cells In Vivo." PLoS One In: , Vol. 7, No. 10, e48045, 22.10.2012.
  • "Amino-terminal ligands prolong NMDA receptor- mediated EPSCs." Journal of Neuroscience In: , Vol. 32, No. 23, 06.06.2012, p. 8065-8073.
  • "Short-term field stimulation mimics synaptic maturation of hippocampal synapses." Journal of Physiology In: , Vol. 590, No. 7, 04.2012, p. 1641-1654.
  • "The time course of NMDA receptor-mediated synaptic currents."  The NMDA Receptor. Oxford University Press, 2012.
  • "Dentate gyrus neurogenesis, integration and microRNAs." Behavioural Brain Research In: , Vol. 227, No. 2, 14.02.2012, p. 348-355.
  • "Ligand-gated ion channels."  Cell Physiology Source Book. Elsevier Inc., 2012. p. 549-562.
  • "Early developmental actions of endocrine disruptors on the hypothalamus, hippocampus, and cerebral cortex." Journal of Toxicology and Environmental Health - Part B: Critical Reviews In: , Vol. 14, No. 5-7, 07.2011, p. 328-345.
  • "Membrane and synaptic properties of pyramidal neurons in the anterior olfactory nucleus." Journal of Neurophysiology In: , Vol. 105, No. 4, 04.2011, p. 1444-1453.
  • "Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli." Journal of Physiology In: , Vol. 589, No. 8, 04.2011, p. 1927-1941.

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