Photo of Eric S. Orwoll, M.D.

Eric S. Orwoll M.D.

    • Professor of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition School of Medicine

Dr. Orwoll specializes in the evaluation and care of patients with osteoporosis, other forms of metabolic bone disorders, and abnormalities of calcium metabolism. He is professor of medicine and attending physician in the bone and mineral section of the Division of Endocrinology, Diabetes, and Clinical Nutrition, and has been the director of the Bone and Mineral Clinic, and of the Bone Density Lab.

He is an internationally recognized expert in the area of bone biology and metabolic bone disease, and has considerable experience in basic, clinical, and epidemiological investigation. Major areas of research interest include the epidemiology, etiology and therapy of osteoporosis in men, the evaluation of new diagnostics and therapeutics, osteogenesis imperfecta, effects of sex steroids on skeletal biology, and skeletal genetics/proteomics.

He has been the principle investigator for many projects supported by the National Institutes of Health, VA and foundations, and is the author of more than 400 peer reviewed publications, reviews, books, and book chapters. He is also an experienced leader in academic medicine who has had extensive responsibility for clinical and translational research planning and management. He has been the associate vice-president for research at OHSU, associate dean for clinical research in the School of Medicine, and the director of the Oregon Clinical and Translational Research Institute. Dr. Orwoll receives research support from the National Institutes of Health, the Osteogenesis Imperfecta Foundation, Merck, and Eli Lilly.

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  • Residency:

    • Medicine-Providence Medical Center, Portland
  • Fellowship:

    • Endocrinology-Oregon Health & Science University, Portland
  • Certifications:

    • Internal medicine, endocrinology, and metabolism


  • "Exome-wide rare variant analyses of two bone mineral density phenotypes : The challenges of analyzing rare genetic variation." Scientific Reports In: , Vol. 8, No. 1, 220, 01.12.2018.
  • "Association of High-resolution Peripheral Quantitative Computed Tomography (HR-pQCT) bone microarchitectural parameters with previous clinical fracture in older men : The Osteoporotic Fractures in Men (MrOS) study." Bone  In: , Vol. 113, 01.08.2018, p. 49-56.
  • "Phylogenetic placement of exact amplicon sequences improves associations with clinical information." mSystems  In: , Vol. 3, No. 3, e00021-18, 01.05.2018.
  • "Weight loss in men in late life and bone strength and microarchitecture : a prospective study." Osteoporosis International  In: , 23.03.2018, p. 1-10.
  • "Serum sodium and cognition in older community-dwelling men." Clinical Journal of the American Society of Nephrology  In: , Vol. 13, No. 3, 07.03.2018, p. 366-374.
  • "Falls Predict Fractures Independently of FRAX Probability : A Meta-Analysis of the Osteoporotic Fractures in Men (MrOS) Study." Journal of Bone and Mineral Research  In: , Vol. 33, No. 3, 01.03.2018, p. 510-516.
  • "Dietary patterns and longitudinal change in hip bone mineral density among older men." Osteoporosis International  In: , 15.02.2018, p. 1-11.
  • "Serum Sclerostin Levels in Adults With Osteogenesis Imperfecta : Comparison With Normal Individuals and Response to Teriparatide Therapy." Journal of Bone and Mineral Research  In: , Vol. 33, No. 2, 01.02.2018, p. 307-315.
  • "The epidemiology of wrist fractures in older men : the Osteoporotic Fractures in Men (MrOS) study." Osteoporosis International  In: , 17.01.2018, p. 1-12.
  • "Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects." American Journal of Human Genetics  In: , Vol. 102, No. 1, 04.01.2018, p. 88-102.
  • "The importance of the circadian system & sleep for bone health." Metabolism: Clinical and Experimental In: , 01.01.2018.
  • "High-throughput serum proteomics for the identification of protein biomarkers of mortality in older men." Aging Cell  In: , 01.01.2018.
  • "Osteoporosis and Hip Fracture Risk From Routine Computed Tomography Scans : The Fracture, Osteoporosis, and CT Utilization Study (FOCUS)." Journal of Bone and Mineral Research In: , 01.01.2018.
  • "Volumetric Bone Mineral Density and Failure Load of Distal Limbs Predict Incident Clinical Fracture Independent HR-pQCT BMD and Failure Load Predicts Incident Clinical Fracture of FRAX and Clinical Risk Factors Among Older Men." Journal of Bone and Mineral Research In: , 01.01.2018.
  • "Comparison of fracture risk assessment tools in older men without prior hip or spine fracture : the MrOS study." Archives of Osteoporosis  In: , Vol. 12, No. 1, 91, 01.12.2017.
  • "Large meta-analysis of genome-wide association studies identifies five loci for lean body mass." Nature Communications In: , Vol. 8, No. 1, 80, 01.12.2017.
  • "Correction to : Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study (Arch Osteoporos, 10.1007/s11657-017-0389-1)." Archives of Osteoporosis  In: , Vol. 12, No. 1, 99, 01.12.2017.
  • "Rest-activity circadian rhythms and bone mineral density in elderly men." Bone Reports  In: , Vol. 7, 01.12.2017, p. 156-163.
  • "Association of incident hip fracture with the estimated femoral strength by finite element analysis of DXA scans in the Osteoporotic Fractures in Men (MrOS) study." Osteoporosis International  In: , 22.11.2017, p. 1-9.
  • "Evaluating Atypical Features of Femur Fractures : How Change in Radiological Criteria Influenced Incidence and Demography of Atypical Femur Fractures in a Community Setting." Journal of Bone and Mineral Research In: , Vol. 32, No. 11, 01.11.2017, p. 2304-2314.
  • "High dairy protein intake is associated with greater bone strength parameters at the distal radius and tibia in older men : a cross-sectional study." Osteoporosis International  In: , 23.10.2017, p. 1-9.
  • "Obesity and Falls in a Prospective Study of Older Men : The Osteoporotic Fractures in Men Study." Journal of Aging and Health In: , Vol. 29, No. 7, 01.10.2017, p. 1235-1250.
  • "Clinical Definitions of Sarcopenia and Risk of Hospitalization in Community-Dwelling Older Men : The Osteoporotic Fractures in Men Study." Journals of Gerontology - Series A Biological Sciences and Medical Sciences In: , Vol. 72, No. 10, 01.10.2017, p. 1383-1389.
  • "Bone Turnover Markers After Sleep Restriction and Circadian Disruption : A Mechanism for Sleep-Related Bone Loss in Humans." The Journal of clinical endocrinology and metabolism In: , Vol. 102, No. 10, 01.10.2017, p. 3722-3730.
  • "Successful collection of stool samples for microbiome analyses from a large community-based population of elderly men." Contemporary Clinical Trials Communications In: , Vol. 7, 01.09.2017, p. 158-162.
  • "Screening for Osteoporosis in Older Men : Operating Characteristics of Proposed Strategies for Selecting Men for BMD Testing." Journal of General Internal Medicine  In: , 16.08.2017, p. 1-7.
  • "Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis." American Journal of Human Genetics  In: , Vol. 101, No. 2, 03.08.2017, p. 227-238.
  • "NFAT5 and SLC4A10 loci associate with plasma osmolality." Journal of the American Society of Nephrology In: , Vol. 28, No. 8, 01.08.2017, p. 2311-2321.
  • "24-hour profile of serum sclerostin and its association with bone biomarkers in men." Osteoporosis International In: , 26.07.2017, p. 1-9.
  • "Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness." Nature Communications  In: , Vol. 8, 16015, 12.07.2017.

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