Photo of Eric S. Orwoll, M.D.

Eric S. Orwoll M.D.

    • Professor of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition School of Medicine

Dr. Orwoll specializes in the evaluation and care of patients with osteoporosis, other forms of metabolic bone disorders, and abnormalities of calcium metabolism. He is professor of medicine and attending physician in the bone and mineral section of the Division of Endocrinology, Diabetes, and Clinical Nutrition, and has been the director of the Bone and Mineral Clinic, and of the Bone Density Lab.

He is an internationally recognized expert in the area of bone biology and metabolic bone disease, and has considerable experience in basic, clinical, and epidemiological investigation. Major areas of research interest include the epidemiology, etiology and therapy of osteoporosis in men, the evaluation of new diagnostics and therapeutics, osteogenesis imperfecta, effects of sex steroids on skeletal biology, and skeletal genetics/proteomics.

He has been the principle investigator for many projects supported by the National Institutes of Health, VA and foundations, and is the author of more than 400 peer reviewed publications, reviews, books, and book chapters. He is also an experienced leader in academic medicine who has had extensive responsibility for clinical and translational research planning and management. He has been the associate vice-president for research at OHSU, associate dean for clinical research in the School of Medicine, and the director of the Oregon Clinical and Translational Research Institute. Dr. Orwoll receives research support from the National Institutes of Health, the Osteogenesis Imperfecta Foundation, Merck, and Eli Lilly.

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  • Residency:

    • Medicine-Providence Medical Center, Portland
  • Fellowship:

    • Endocrinology-Oregon Health & Science University, Portland
  • Certifications:

    • Internal medicine, endocrinology, and metabolism

Publications

  • "Clinical practice guidelines for osteoporosis : Translating data to patients?" Annals of Internal Medicine In: , Vol. 166, No. 11, 06.06.2017, p. 852-853.
  • "Trajectories of the relationships of physical activity with body composition changes in older men : the MrOS study." BMC Geriatrics In: , Vol. 17, No. 1, 119, 05.06.2017.
  • "Harmonized reference ranges for circulating testosterone levels in men of four cohort studies in the United States and Europe." Journal of Clinical Endocrinology and Metabolism  In: , Vol. 102, No. 4, 01.04.2017, p. 1161-1173.
  • "Further elucidation of the potential benefits of testosterone therapy in older men." JAMA Internal Medicine  In: , Vol. 177, No. 4, 01.04.2017, p. 459-460.
  • "Comparing identified and statistically significant lipids and polar metabolites in 15-year old serum and dried blood spot samples for longitudinal studies." Rapid Communications in Mass Spectrometry In: , Vol. 31, No. 5, 15.03.2017, p. 447-456.
  • "The Association Between Protein Intake by Source and Osteoporotic Fracture in Older Men : A Prospective Cohort Study." Journal of Bone and Mineral Research In: , 2017.
  • "Low Testosterone, but Not Estradiol, Is Associated With Incident Falls in Older Men : The International MrOS Study." Journal of Bone and Mineral Research  In: , 2017.
  • "Association of Increased Urinary Albumin With Risk of Incident Clinical Fracture and Rate of Hip Bone Loss : The Osteoporotic Fractures in Men Study." Journal of Bone and Mineral Research In: , 2017.
  • "Association of Trabecular Bone Score (TBS) With Incident Clinical and Radiographic Vertebral Fractures Adjusted for Lumbar Spine BMD in Older Men : A Prospective Cohort Study." Journal of Bone and Mineral Research In: , 2017.
  • "Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics." Journal of Bone and Mineral Research In: , 2017.
  • "Rest-activity patterns and falls and fractures in older men." Osteoporosis International In: , 24.12.2016, p. 1-10.
  • "Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2." Journal of Bone and Mineral Research  In: , Vol. 31, No. 12, 01.12.2016, p. 2085-2097.
  • "SHBG, Sex Steroids, and Kyphosis in Older Men : The MrOS Study." Journal of Bone and Mineral Research  In: , Vol. 31, No. 12, 01.12.2016, p. 2123-2128.
  • "Areal and volumetric bone mineral density and risk of multiple types of fracture in older men." Bone In: , Vol. 92, 01.11.2016, p. 100-106.
  • "Erratum to : Clinical utility of routine laboratory testing to identify possible secondary causes in older men with osteoporosis: the osteoporotic fractures in men (MrOS) study." Osteoporosis International  In: , 20.10.2016, p. 1-2.
  • "Sensorimotor peripheral nerve function and physical activity in older men." Journal of Aging and Physical Activity In: , Vol. 24, No. 4, 01.10.2016, p. 559-566.
  • "Thyroid Function Variations Within the Reference Range Do Not Affect Quality of Life, Mood, or Cognitive Function in Community-Dwelling Older Men." Thyroid  In: , Vol. 26, No. 9, 01.09.2016, p. 1185-1194.
  • "Comparison of Associations of DXA and CT Visceral Adipose Tissue Measures With Insulin Resistance, Lipid Levels, and Inflammatory Markers." Journal of Clinical Densitometry In: , 01.09.2016.
  • "What Proportion of Incident Radiographic Vertebral Fractures in Older Men Is Clinically Diagnosed and Vice Versa : A Prospective Study." Journal of Bone and Mineral Research In: , Vol. 31, No. 8, 01.08.2016, p. 1500-1503.
  • "Association of 3D Geometric Measures Derived From Quantitative Computed Tomography With Hip Fracture Risk in Older Men." Journal of Bone and Mineral Research In: , Vol. 31, No. 8, 01.08.2016, p. 1550-1558.
  • "Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training." Osteoporosis International In: , 30.07.2016, p. 1-13.
  • "Characterization of FN1–FGFR1 and novel FN1–FGF1 fusion genes in a large series of phosphaturic mesenchymal tumors." Modern Pathology In: , 22.07.2016.
  • "Association of urinary melatonin levels and aging-related outcomes in older men." Sleep Medicine In: , Vol. 23, 01.07.2016, p. 73-80.
  • "Passing the baton - Harnessing the full value of older scientists." New England Journal of Medicine  In: , Vol. 374, No. 26, 30.06.2016, p. 2514-2517.
  • "Predictors of non-vertebral fracture in older Chinese males and females : Mr. OS and Ms. OS (Hong Kong)." Journal of Bone and Mineral Metabolism  In: , 25.05.2016, p. 1-8.
  • "Free 25-hydroxyvitamin D : Impact of vitamin D binding protein assays on racial-genotypic associations." Journal of Clinical Endocrinology and Metabolism In: , Vol. 101, No. 5, 01.05.2016, p. 2226-2234.
  • "Sex hormones, sex hormone binding globulin, and vertebral fractures in older men." Bone In: , Vol. 84, 01.03.2016, p. 271-278.
  • "Associations of total and free 25OHD and 1,25(OH)D with serum markers of inflammation in older men." Osteoporosis International  In: , 23.02.2016, p. 1-10.
  • "Actigraphy- and Polysomnography-Measured Sleep Disturbances, Inflammation, and Mortality Among Older Men." Psychosomatic Medicine In: , 18.02.2016.
  • "Establishing a framework-does testosterone supplementation help older men?" New England Journal of Medicine In: , Vol. 374, No. 7, 18.02.2016, p. 682-683.

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