Photo of Eric Barklis, Ph.D.

Eric Barklis Ph.D.

  • (503) 494-2429
    • Professor of Molecular Microbiology and Immunology School of Medicine
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine

Education

  • B.S., Massachusetts Institute of Technology, Cambridge Massachusetts 1973
  • Ph.D., Massachusetts Institute of Technology, Cambridge Massachusetts 1984

Publications

  • "Analysis of quinolinequinone reactivity, cytotoxicity, and anti-HIV-1 properties." Bioorganic and Medicinal Chemistry  In: , Vol. 24, No. 21, 01.11.2016, p. 5618-5625.
  • "Trimer enhancement mutation effects on HIV-1 matrix protein binding activities." Journal of Virology  In: , Vol. 90, No. 12, 01.06.2016, p. 5657-5664.
  • "Analysis of HIV-1 gag protein interactions via biotin ligase tagging." Journal of Virology  In: , Vol. 89, No. 7, 2015, p. 3988-4001.
  • "The roles of lipids and nucleic acids in HIV-1 assembly." Frontiers in Microbiology  In: , Vol. 5, No. MAY, 2014.
  • "RRE-dependent HIV-1 Env RNA effects on Gag protein expression, assembly and release." Virology  In: , Vol. 462-463, No. 1, 2014, p. 126-134.
  • "Second site reversion of a mutation near the amino terminus of the HIV-1 capsid protein." Virology  In: , Vol. 447, No. 1-2, 12.2013, p. 95-103.
  • "Virus assembly as a target for antiretroviral therapy."   Advances in HIV-1 Assembly and Release. Springer New York, 2013. p. 185-214.
  • "Analysis of small molecule ligands targeting the HIV-1 matrix protein-RNA binding site." Journal of Biological Chemistry  In: , Vol. 288, No. 1, 04.01.2013, p. 666-676.
  • "Sultam thioureas : Synthesis and antiviral activity against west nile virus." Synlett  In: , No. 2, 2012, p. 301-305.
  • "Determinants of the HIV-1 core assembly pathway." Virology  In: , Vol. 417, No. 1, 15.08.2011, p. 137-146.
  • "HIV-1 matrix protein binding to RNA." Journal of Molecular Biology  In: , Vol. 410, No. 4, 22.07.2011, p. 653-666.
  • "Second-site compensatory mutations of HIV-1 capsid mutations." Journal of Virology  In: , Vol. 85, No. 10, 05.2011, p. 4730-4738.
  • "Analysis of the N-terminal region of the murine leukemia virus nucleocapsid protein." Virus Research  In: , Vol. 155, No. 1, 01.2011, p. 181-188.
  • "Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action." Molecular Biology of the Cell  In: , Vol. 21, No. 19, 01.10.2010, p. 3279-3292.
  • "Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis." Molecular and Cellular Biology  In: , Vol. 30, No. 4, 02.2010, p. 935-947.
  • "Analysis of human immunodeficiency virus type 1 matrix binding to membranes and nucleic acids." Journal of Virology  In: , Vol. 83, No. 23, 12.2009, p. 12196-12203.
  • "HIV-1 matrix organizes as a hexamer of trimers on membranes containing phosphatidylinositol-(4,5)-bisphosphate." Virology  In: , Vol. 387, No. 2, 10.05.2009, p. 466-472.
  • "Characterization of the In Vitro HIV-1 Capsid Assembly Pathway." Journal of Molecular Biology In: , Vol. 387, No. 2, 27.03.2009, p. 376-389.
  • "Analysis of human immunodeficiency virus matrix domain replacements." Virology  In: , Vol. 371, No. 2, 20.02.2008, p. 322-335.
  • "Sultam thiourea inhibition of West Nile virus." Antimicrobial Agents and Chemotherapy  In: , Vol. 51, No. 7, 07.2007, p. 2642-2645.
  • "HIV-1 Nef Assembles a Src Family Kinase-ZAP-70/Syk-PI3K Cascade to Downregulate Cell-Surface MHC-I." Cell Host and Microbe  In: , Vol. 1, No. 2, 19.04.2007, p. 121-133.
  • "Human immunodeficiency virus type 1 matrix protein assembles on membranes as a hexamer." Journal of Virology  In: , Vol. 81, No. 3, 02.2007, p. 1472-1478.
  • "Analysis of human immunodeficiency virus type 1 Gag dimerization-induced assembly." Journal of Virology  In: , Vol. 79, No. 23, 12.2005, p. 14498-14506.
  • "Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication." Retrovirology  In: , Vol. 2, 58, 27.09.2005.
  • "Virus particle core defects caused by mutations in the human immunodeficiency virus capsid N-terminal domain." Journal of Virology  In: , Vol. 79, No. 3, 02.2005, p. 1470-1479.
  • "Antiviral Inhibition of the HIV-1 capsid protein." Journal of Molecular Biology In: , Vol. 327, No. 5, 11.04.2003, p. 1013-1020.
  • "Analysis of the retrovirus capsid interdomain linker region." Virology  In: , Vol. 308, No. 1, 30.03.2003, p. 166-177.
  • "Retrovirus capsid protein assembly arrangements." Journal of Molecular Biology  In: , Vol. 325, No. 1, 2003, p. 225-237.
  • "EMXtalOrg : An EM tilt data organization and processing system." Ultramicroscopy  In: , Vol. 93, No. 1, 10.2002, p. 11-17.
  • "Hantavirus nucleocapsid protein coiled-coil domains." Journal of Biological Chemistry  In: , Vol. 277, No. 30, 26.07.2002, p. 27103-27108.

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