Photo of Edward A. Neuwelt, M.D.

Edward A. Neuwelt M.D.

    • Professor of Neurology School of Medicine
    • Neuroscience Graduate Program School of Medicine

After receiving his medical degree from the University of Colorado Medical School, Denver, in 1972, Dr. Neuwelt completed his neurosurgery residency at the University of Texas Southwest Medical School in Dallas. He continued his medical education by completing his neurosurgery fellowship at the Queen Square Hospital in London, England. His special interests include neurooncology and microsurgery. Dr. Neuwelt currently serves as the director of the Blood Brain Barrier Program, and the administrator of the Head and Spinal Cord Injury Prevention Program.

  • Residency:

    • Neurosurgery-University of Texas Southwest Medical School, Dallas
  • Fellowship:

    • Neurosurgery-Queen Square Hospital, London, England

Memberships and associations

  • Neurosurgery, 1980

Publications

  • "Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency." Fluids and Barriers of the CNS In: , Vol. 14, No. 1, 26, 03.10.2017.
  • "High αv integrin level of cancer cells is associated with development of brain metastasis in athymic rats." Anticancer Research In: , Vol. 37, No. 8, 01.08.2017, p. 4029-4040.
  • "Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors." Cancer Gene Therapy In: , Vol. 24, No. 8, 01.08.2017, p. 348-357.
  • "Current and potential imaging applications of ferumoxytol for magnetic resonance imaging." Kidney International In: , Vol. 92, No. 1, 01.07.2017, p. 47-66.
  • "What does the boxed warning tell us? Safe practice of using ferumoxytol as an MRI CONTRAST AGENT." American Journal of Neuroradiology In: , Vol. 38, No. 7, 01.07.2017, p. 1297-1302.
  • "Patterns of relapse in primary central nervous system lymphoma : Inferences regarding the role of the neuro-vascular unit and monoclonal antibodies in treating occult CNS disease." Fluids and Barriers of the CNS In: , Vol. 14, No. 1, 16, 02.06.2017.
  • "Comprehensive Review of the ThinkFirst Injury Prevention Programs : A 30-Year Success Story for Organized Neurosurgery." Neurosurgery In: , 29.03.2017.
  • "Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1) : A Report From the Children's Oncology Group." Journal of clinical oncology : official journal of the American Society of Clinical Oncology  In: , Vol. 35, No. 4, 01.02.2017, p. 440-445.
  • "The translational significance of the neurovascular unit." Journal of Biological Chemistry In: , Vol. 292, No. 3, 20.01.2017, p. 762-770.
  • "Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431) : a multicentre, randomised, controlled, open-label, phase 3 trial." The Lancet Oncology  In: , Vol. 18, No. 1, 01.01.2017, p. 63-74.
  • "Pseudo-extravasation rate constant of dynamic susceptibility contrast-MRI determined from pharmacokinetic first principles." NMR in Biomedicine In: , 2017.
  • "Misleading early blood volume changes obtained using ferumoxytol-based magnetic resonance imaging perfusion in high grade glial neoplasms treated with bevacizumab." Fluids and Barriers of the CNS In: , Vol. 13, No. 1, 23, 20.12.2016.
  • "Ferumoxytol nanoparticle uptake in brain during acute neuroinflammation is cell-specific." Nanomedicine: Nanotechnology, Biology, and Medicine In: , Vol. 12, No. 6, 01.08.2016, p. 1535-1542.
  • "Ferumoxytol-enhanced MRI differentiation of meningioma from dural metastases : a pilot study with immunohistochemical observations." Journal of Neuro-Oncology In: , 08.07.2016, p. 1-9.
  • "Therapy for secondary CNS involvement inmalignant lymphomas : No standard yet!" Journal of Clinical Oncology  In: , Vol. 34, No. 15, 20.05.2016, p. 1829-1830.
  • "Intra-arterial administration improves temozolomide delivery and efficacy in a model of intracerebral metastasis, but has unexpected brain toxicity." Journal of Neuro-Oncology In: , Vol. 126, No. 3, 01.02.2016, p. 447-454.
  • "Safety Report of Ferumoxytol for Magnetic Resonance Imaging in Children and Young Adults." Investigative Radiology In: , 12.12.2015.
  • "Dose-dependent neurotoxicity (seizures) due to deposition of gadolinium-based contrast agents in the central nervous system." Radiology In: , Vol. 277, No. 3, 01.12.2015, p. 925-926.
  • "Interactions between αv-Integrin and HER2 and their role in the invasive phenotype of breast cancer cells in vitro and in rat brain." PLoS One In: , Vol. 10, No. 7, e0131842, 29.07.2015.
  • "Mapping human brain capillary water lifetime : High-resolution metabolic neuroimaging." NMR in Biomedicine In: , Vol. 28, No. 6, 01.06.2015, p. 607-623.
  • "Unsanctifying the sanctuary : Challenges and opportunities with brain metastases." Neuro-Oncology  In: , Vol. 17, No. 5, 01.05.2015, p. 639-651.
  • "Primary CNS lymphoma." Neurology  In: , Vol. 84, No. 12, 24.03.2015, p. 1194-1195.
  • "Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis." Fluids and Barriers of the CNS In: , Vol. 12, No. 1, 5, 17.02.2015.
  • "N-acetylcysteine chemoprotection without decreased cisplatin antitumor efficacy in pediatric tumor models." Journal of Neuro-Oncology In: , Vol. 121, No. 3, 2015, p. 433-440.
  • "Diagnosis of pseudoprogression using MRI perfusion in patients with glioblastoma multiforme may predict improved survival." CNS oncology In: , Vol. 3, No. 6, 01.11.2014, p. 389-400.
  • "Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis." CNS oncology In: , Vol. 3, No. 4, 01.07.2014, p. 267-273.
  • "Evaluation of pseudoprogression in patients with glioblastoma multiforme using dynamic magnetic resonance imaging with ferumoxytol calls RANO criteria into question." Neuro-Oncology In: , Vol. 16, No. 8, 2014, p. 1146-1154.
  • "Preclinical high-dose acetaminophen with N-acetylcysteine rescue enhances the efficacy of cisplatin chemotherapy in atypical teratoid rhabdoid tumors." Pediatric Blood and Cancer In: , Vol. 61, No. 1, 2014, p. 120-127.
  • "Delivery of chemotherapeutics across the blood-brain barrier : Challenges and advances." Advances in Pharmacology In: , Vol. 71, 2014, p. 203-243.
  • "Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder." Journal of NeuroVirology In: , Vol. 19, No. 6, 12.2013, p. 601-605.

Additional information

Edit profile