Photo of Deborah A. Lewinsohn, M.D.

Deborah A. Lewinsohn M.D.

    • Professor of Pediatrics, Division of Infectious Diseases School of Medicine
    • Wayne L. Tracy Professor of Pediatric Infectious Disease Pediatrics School of Medicine
    • Molecular Microbiology and Immunology Graduate Program School of Medicine

Lab:http://www.ohsu.edu/xd/health/services/doernbecher/research-education/research/research-labs/deborah-lewinsohn-lab.cfm

  • Residency:

    • University of California-San Francisco
  • Fellowship:

    • University of Washington, Seattle

Publications

  • "Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target : Lessons from a Phase I Trial of the AERAS-402 Vaccine." Scientific Reports In: , Vol. 6, 36355, 02.11.2016.
  • "Direct TLR-2 costimulation unmasks the proinflammatory potential of neonatal CD4 T cells." Journal of Immunology In: , Vol. 197, No. 1, 01.07.2016, p. 68-77.
  • "High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells." Immunology In: , Vol. 145, No. 3, 01.07.2015, p. 443-453.
  • "Childhood tuberculosis in Northern Viet Nam : A review of 103 cases." PLoS One  In: , Vol. 9, No. 5, e97267, 12.05.2014.
  • "MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage." Journal of Experimental Medicine In: , Vol. 211, No. 8, 2014, p. 1601-1610.
  • "Antigens for CD4 and CD8 T cells in tuberculosis." Cold Spring Harbor perspectives in medicine  In: , Vol. 4, No. 7, 2014.
  • "Mycobacterium tuberculosis specific CD8+ T cells rapidly decline with antituberculosis treatment." PLoS One In: , Vol. 8, No. 12, e81564, 04.12.2013.
  • "TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I." PLoS One In: , Vol. 8, No. 11, e79571, 11.11.2013.
  • "Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library." PLoS One In: , Vol. 8, No. 6, e67016, 21.06.2013.
  • "Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress." Mucosal Immunology In: , Vol. 6, No. 1, 01.2013, p. 35-44.
  • "Evaluation of tuberculosis diagnostics in children : 2. Methodological issues for conducting and reporting research evaluations of tuberculosis diagnostics for intrathoracic tuberculosis in children. Consensus from an expert panel." Journal of Infectious Diseases  In: , Vol. 205, No. SUPPL. 2, 15.05.2012.
  • "Safety and Efficacy of CMX001 as Salvage Therapy for Severe Adenovirus Infections in Immunocompromised Patients." Biology of Blood and Marrow Transplantation  In: , Vol. 18, No. 5, 05.2012, p. 731-738.
  • "CD8 + T cells provide an immunologic signature of tuberculosis in young children." American Journal of Respiratory and Critical Care Medicine In: , Vol. 185, No. 2, 15.01.2012, p. 206-212.
  • "Views of immunology : Effector T cells." Immunological Reviews In: , Vol. 240, No. 1, 03.2011, p. 25-39.
  • "Secreted immunodominant Mycobacterium tuberculosis antigens are processed by the cytosolic pathway." Journal of Immunology In: , Vol. 185, No. 7, 01.10.2010, p. 4336-4343.
  • "Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates (J. Immunol. (2010) 184 (6739-6745))." Journal of Immunology In: , Vol. 185, No. 7, 01.10.2010, p. 4509.
  • "HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV replication and cell death (Journal of Clinical Investigation (2010) 120, 9, (3401) doi : 10.1172/JCI8707R1)." Journal of Clinical Investigation  In: , Vol. 120, No. 9, 01.09.2010, p. 3401.
  • "Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates." Journal of Immunology  In: , Vol. 184, No. 12, 15.06.2010, p. 6739-6745.
  • "Embracing IGRAs in children." International Journal of Tuberculosis and Lung Disease  In: , Vol. 14, No. 6 SUPPL. 1, 06.2010.
  • "Human mucosal associated invariant T cells detect bacterially infected cells." PLoS Biology In: , Vol. 8, No. 6, 06.2010.
  • "Interferon-γ release assays : New diagnostic tests for Mycobacterium tuberculosis infection, and their use in children." Current Opinion in Pediatrics In: , Vol. 22, No. 1, 02.2010, p. 71-76.
  • "Embracing interferon-γ release assays for diagnosis of latent tuberculosis infection." Pediatric Infectious Disease Journal In: , Vol. 28, No. 8, 08.2009, p. 674-675.
  • "The Mycobacterium tuberculosis Phagosome Is a HLA-I Processing Competent Organelle." PLoS Pathogens In: , Vol. 5, No. 4, 04.2009.
  • "New diagnostic methods for tuberculosis." Current Opinion in Infectious Diseases In: , Vol. 22, No. 2, 04.2009, p. 174-182.
  • "Whole blood interferon-gamma responses to Mycobacterium tuberculosis antigens in young household contacts of persons with tuberculosis in Uganda." PLoS One In: , Vol. 3, No. 10, e3407, 15.10.2008.
  • "Interferon-γ release assays for diagnosing mycobacterium tuberculosis infection in renal dialysis patients." Clinical Journal of the American Society of Nephrology In: , Vol. 3, No. 5, 09.2008, p. 1357-1363.
  • "HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV-1 replication and cell death (Journal of Clinical Investigation (2000) 105, (1407-1417) DOI : 10.1172/JCI8707)." Journal of Clinical Investigation  In: , Vol. 118, No. 5, 01.05.2008, p. 1974.
  • "Immunologic susceptibility of young children to Mycobacterium tuberculosis." Pediatric Research In: , Vol. 63, No. 2, 02.2008, p. 115.
  • "Human innate Mycobacterium tuberculosis-reactive αβTCR + thymocytes." PLoS Pathogens In: , Vol. 4, No. 2, 02.2008.
  • "Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B." PLoS Pathogens In: , Vol. 3, No. 9, 09.2007, p. 1240-1249.

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