Photo of David M. Lewinsohn, M.D., Ph.D.

David M. Lewinsohn M.D., Ph.D.

    • Professor of Medicine, Division of Pulmonary and Critical Care Medicine School of Medicine
    • Molecular Microbiology and Immunology Graduate Program School of Medicine

After receiving his B.S. in biology from Haverford College, David Lewinsohn attended Stanford University School of Medicine. In 1989 he received his Ph.D. in cancer biology and received his M.D. the same year. Dr. Lewinsohn was a Fellow of Pulmonary and Critical Care Medicine at the University of Washington, Seattle, WA, from 1993-1996, and a senior fellow and acting instructor from 1996-1998. During 1996-1998 he was also an investigator at the Infectious Disease Research Institute in Seattle, WA.

Education

  • M.D., Ph.D., Stanford University, Palo Alto California 1989
  • Residency:

    • Categorical Internal Medicine Residency, University of California, San Francisco 1992
  • Fellowship:

    • Categorical Internal Medicine Internship, University of California San Francisco 1990Pulmonary and Critical Care Medicine, University of Washington 1996
  • Certifications:

    • Pulmonary 1996Critical Care Medicine 1997

Publications

  • "HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8 T cells." Scientific Reports In: , Vol. 7, No. 1, 4622, 01.12.2017.
  • "The Mycobacterium tuberculosis MmpL11 cell wall lipid transporter is important for biofilm formation, intracellular growth, and nonreplicating persistence." Infection and Immunity In: , Vol. 85, No. 8, 00131-17, 01.08.2017.
  • "MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates." Mucosal Immunology In: , Vol. 10, No. 3, 01.05.2017, p. 802-813.
  • "Diagnosis of tuberculosis in adults and children." Annals of the American Thoracic Society In: , Vol. 14, No. 2, 01.02.2017, p. 275-278.
  • "Official American thoracic society/Infectious diseases society of America/Centers for disease control and prevention clinical practice guidelines : diagnosis of tuberculosis in adults and children." Clinical Infectious Diseases In: , Vol. 64, No. 2, 2017, p. 111-115.
  • "Official American thoracic society/Infectious diseases society of America/Centers for disease control and prevention clinical practice guidelines : Diagnosis of tuberculosis in adults and children[1]." Clinical Infectious Diseases In: , Vol. 64, No. 2, 2017, p. e1-e33.
  • "A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis." Genes and Immunity In: , 24.11.2016.
  • "Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target : Lessons from a Phase I Trial of the AERAS-402 Vaccine." Scientific Reports In: , Vol. 6, 36355, 02.11.2016.
  • "Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens." Nature Communications In: , Vol. 7, 12506, 16.08.2016.
  • "Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system : Tools to study microbial antigen processing and presentation to human mr1-restricted t cells." Journal of Immunology In: , Vol. 197, No. 3, 01.08.2016, p. 971-982.
  • "Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells." PLoS Pathogens In: , Vol. 12, No. 3, e1005524, 01.03.2016.
  • "A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents." Tuberculosis In: , Vol. 95, No. 6, 01.12.2015, p. 713-721.
  • "High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells." Immunology In: , Vol. 145, No. 3, 01.07.2015, p. 443-453.
  • "MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis." Immunological Reviews In: , Vol. 264, No. 1, 01.03.2015, p. 154-166.
  • "The role of mucosal associated invariant T cells in antimicrobial immunity." Frontiers in Immunology In: , Vol. 6, No. JUN, 344, 2015.
  • "ATS Core Curriculum 2014 : part I. Adult pulmonary medicine." Annals of the American Thoracic Society In: , Vol. 11, No. 7, 01.09.2014, p. 1136-1144.
  • "Human lung epithelial cells contain Mycobacterium tuberculosis in a late endosomal vacuole and are efficiently recognized by CD8+ T Cells." PLoS One In: , Vol. 9, No. 5, e97515, 14.05.2014.
  • "MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage." Journal of Experimental Medicine In: , Vol. 211, No. 8, 2014, p. 1601-1610.
  • "Antigens for CD4 and CD8 T cells in tuberculosis." Cold Spring Harbor perspectives in medicine  In: , Vol. 4, No. 7, 2014.
  • "T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence." PLoS Pathogens  In: , Vol. 10, No. 5, e1004123, 2014.
  • "Low levels of peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) cells are found in HIV and HIV/TB co-infection." PLoS One In: , Vol. 8, No. 12, e83474, 31.12.2013.
  • "Mycobacterium tuberculosis specific CD8+ T cells rapidly decline with antituberculosis treatment." PLoS One In: , Vol. 8, No. 12, e81564, 04.12.2013.
  • "TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I." PLoS One In: , Vol. 8, No. 11, e79571, 11.11.2013.
  • "Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library." PLoS One In: , Vol. 8, No. 6, e67016, 21.06.2013.
  • "Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis." Journal of Immunology  In: , Vol. 190, No. 1, 01.01.2013, p. 278-284.
  • "Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress." Mucosal Immunology In: , Vol. 6, No. 1, 01.2013, p. 35-44.
  • "Co-dependents : MR1-restricted MAIT cells and their antimicrobial function." Nature Reviews Microbiology In: , Vol. 11, No. 1, 01.2013, p. 14-19.
  • "CD8 + T cells provide an immunologic signature of tuberculosis in young children." American Journal of Respiratory and Critical Care Medicine In: , Vol. 185, No. 2, 15.01.2012, p. 206-212.
  • "Escape from the phagosome : The explanation for MHC-I processing of mycobacterial antigens?" Frontiers in Immunology In: , Vol. 3, No. MAR, 40, 2012.
  • "Stereological analysis of bacterial load and lung lesions in nonhuman primates (rhesus macaques) experimentally infected with Mycobacterium tuberculosis." American Journal of Physiology - Lung Cellular and Molecular Physiology In: , Vol. 301, No. 5, 11.2011.

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