Photo of David B. Morton, BA, Ph.D.

David B. Morton BA, Ph.D.

  • Portland Campus

    • Professor of Integrative Biosciences School of Dentistry
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Areas of interest

  • Neuroscience
  • Drosophila neurobiology
  • Neurodegeneration
  • Genetics
  • Signal transduction

Education

  • B.A., The University of Cambridge United Kingdom 1980
  • Ph.D., The University of Cambridge United Kingdom 1983

Honors and awards

  • Fulbright-Hayes Travel Grant
  • 1991 - 1993 Alfred P. Sloan Research Fellowship
  • 1991 NINDS First Award
  • 2000 Dean’s Research Award, School of Dentistry, OHSU
  • 2002, 2007 Finalist, OHSU Faculty Senate Awards in Research
  • 2008 Outstanding Researcher in Biological Science – Sigma Xi, Columbia-Willamette chapter
  • 2012 Finalist, OHSU Faculty Senate Awards in Collaboration
  • 2013 Finalist, OHSU Faculty Senate Awards in Research
  • 2014 Elected honorary member; Omicron Kappa Upsilon Delta

Publications

Selected publications

  • Morton, D.B. (2004).  Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors. J. Biol. Chem. 279:50651-50653. PMID: 15485853

  • Morton, D.B. and Vermehren, A. (2007). Soluble Guanylyl Cyclases in Invertebrates: targets for NO and O2. In Advances in Experimental Biology on Nitric Oxide pp 65-82, Eds. B.A. Trimmer and B. Tota, Elsevier Press. PMID: 19122779, PMCID: PMC2613308

  • Morton, D.B., Stewart, J.A., Langlais, K.K., Clemens-Grisham, R. and Vermehren, A. (2008). Synaptic transmission in neurons that express the Drosophila atypical soluble guanylyl cyclases, Gyc-89Da and Gyc-89Db, is necessary for the successful completion of larval and adult ecdysis. J. exp. Biol. 211, 1645-1656. PMID: 18456892, PMCID: PMC2424211

  • Zimmer, M., Gray, J.M., Pokala, N., Chang, A.J., Karow, D.S., Marletta, M.A., Hudson, M.L., Morton, D.B., Chronis, N. and Bargmann, C.I. (2009). Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron 61, 865-879. PMID: 19323996, PMCID: PMC2760494

  • Morton, D. B., Clemens-Grisham, R., Hazelett, D.J. and Vermehren-Schmaedick, A. (2010). Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster. Genetics 186: 159–165. PMID: 20551439, PMCID: PMC2940284

  • Vermehren-Schmaedick, A. Ainsley, J.A., Johnson, W.A., Davies, S-A. and Morton, D.B. (2010). Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics 186: 183–196. PMID: 20592263 PMCID: PMC2940286

  • Hazelett, D.J., Chang, J-C., Lakeland, D.L. and Morton, D.B. (2012). Comparison of parallel hi-throughput RNA-sequencing between knockout of TDP-43 and its overexpression reveals primarily non-reciprocal and non-overlapping gene expression changes in the central nervous system of Drosophila. G3:Genes, Genomes, Genetics 2, 789-802. PMID: 22870402, PMCID: PMC3385985.

  • Brown, K.M., Day, J.P., Huston, E., Zimmermann, B., Hampel, K., Christian, F., Romano, D., Terhzaz, S., Lee, L.C.Y., Willis, M.J., Morton, D.B., Beavo, J.A., Shimizu-Albergine, M., Davies, S.A., Kolch, W., Houslay, M.D. and Baillie, G.S. (2013). Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proc. Natl. Acad. Sci. 110, E1533-42. PMID: 23509299; PMCID: PMC3631629.

  • Vanderwerf, S.M., Buck, D.C., Wilmarth, P.A., David, L.L., Sears, L.M., Morton, D.B. and Neve, K.A. (2015). Role for Rab10 in methamphetamine-induced behavior. PloS One 10(8): e0136167. doi:10.1371. PMID: 26291453; PMCID: PMC4546301.

Publications

  • "Restoration of motor defects caused by loss of drosophila TDP-43 by expression of the voltage-gated calcium channel, cacophony, in central neurons." Journal of Neuroscience In: , Vol. 37, No. 39, 27.09.2017, p. 9486-9497.
  • "Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects." PLoS ONE In: , Vol. 12, No. 7, e0180828, 01.07.2017.
  • "Exploring the interaction of drosophila TDP-43 and the type ii voltage-gated calcium channel, cacophony, in regulating motor function and behavior." Journal of Experimental Neuroscience In: , Vol. 11, 01.01.2017.
  • "Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta." Insect Biochemistry and Molecular Biology In: , Vol. 76, 01.09.2016, p. 118-147.
  • "Role for Rab10 in methamphetamine-induced behavior." PLoS One In: , Vol. 10, No. 8, e0136167, 20.08.2015.
  • "Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS." Brain Research In: , Vol. 1584, 10.10.2014, p. 39-51.
  • "Phosphodiesterase-8A binds to and regulates Raf-1 kinase." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 110, No. 16, 16.04.2013.
  • "Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of drosophila." G3: Genes, Genomes, Genetics In: , Vol. 2, No. 7, 07.2012, p. 789-802.
  • "Drosophila gustatory preference behaviors require the atypical soluble guanylyl cyclases." Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology In: , Vol. 197, No. 7, 07.2011, p. 717-727.
  • "Behavioral responses to hypoxia and hyperoxia in Drosophila larvae molecular and neuronal sensors." Fly In: , Vol. 5, No. 2, 04.2011, p. 119-125.
  • "Response properties of visual neurons in the turtle nucleus isthmi." Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology  In: , Vol. 197, No. 2, 2011, p. 153-165.
  • "Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster." Genetics  In: , Vol. 186, No. 1, 09.2010, p. 159-165.
  • "Behavioral responses to hypoxia in drosophila larvae are mediated by atypical soluble guanylyl cyclases." Genetics In: , Vol. 186, No. 1, 09.2010, p. 183-196.
  • "Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases." Neuron In: , Vol. 61, No. 6, 26.03.2009, p. 865-879.
  • "Synaptic transmission in neurons that express the Drosophila atypical soluble guanylyl cyclases, Gyc-89Da and Gyc-89Db, is necessary for the successful completion of larval and adult ecdysis." Journal of Experimental Biology  In: , Vol. 211, No. 10, 05.2008, p. 1645-1656.
  • "Soluble guanylyl cyclases in invertebrates : Targets for NO and O2." Advances in Experimental Biology  In: , Vol. 1, 2007, p. 65-82.
  • "Oxygen-sensitive guanylyl cyclases in insects and their potential roles in oxygen detection and in feeding behaviors." Journal of Insect Physiology In: , Vol. 52, No. 4, 04.2006, p. 340-348.
  • "Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster." Journal of Insect Science  In: , Vol. 5, 19.04.2005, p. 1-10.
  • "Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors." Journal of Biological Chemistry In: , Vol. 279, No. 49, 03.12.2004, p. 50651-50653.
  • "Preliminary characterization of two atypical soluble guanylyl cyclases in the central and peripheral nervous system of Drosophila melanogaster." Journal of Experimental Biology In: , Vol. 207, No. 13, 06.2004, p. 2323-2338.
  • "Invertebrates yield a plethora of atypical guanylyl cyclases." Molecular Neurobiology In: , Vol. 29, No. 2, 04.2004, p. 97-115.
  • "MsGC-β3 forms active homodimers and inactive heterodimers with NO-sensitive soluble guanylyl cyclase subunits." Journal of Experimental Biology In: , Vol. 206, No. 6, 03.2003, p. 937-947.
  • "MsGC-II, a receptor guanylyl cyclase isolated from the CNS of Manduca sexta that is inhibited by calcium." Journal of Neurochemistry  In: , Vol. 84, No. 2, 01.2003, p. 363-372.
  • "Nicotinic-acetylcholine receptors are functionally coupled to the nitric oxide/cGMP-pathway in insect neurons." Journal of Neurochemistry In: , Vol. 83, No. 2, 10.2002, p. 421-431.
  • "Cellular signaling in eclosion hormone action." Journal of Insect Physiology  In: , Vol. 48, No. 1, 2002, p. 1-13.
  • "Cyclic GMP regulation and function in insects." Advances in Insect Physiology In: , Vol. 29, 2002, p. 1-54.
  • "The novel guanylyl cyclase MsGC-I is strongly expressed in higher-order neuropils in the brain of Manduca sexta." Journal of Experimental Biology In: , Vol. 204, No. 2, 2001, p. 305-314.
  • "Identification of the cellular target for eclosion hormone in the abdominal transverse nerves of the tobacco hornworm, Manduca sexta." Journal of Comparative Neurology In: , Vol. 424, No. 2, 21.08.2000, p. 339-355.
  • "Neurons involved in nitric oxide-mediated cGMP signaling in the tobacco hornworm, Manduca sexta." Journal of Comparative Neurology In: , Vol. 419, No. 4, 17.04.2000, p. 422-438.
  • "Soluble guanylyl cyclases in Caenorhabditis elegans : NO is not the answer [1]." Current Biology In: , Vol. 9, No. 15, 12.08.1999.

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