Photo of David B. Jacoby, M.D.

David B. Jacoby M.D.

    • Professor of Medicine, Division of Pulmonary and Critical Care Medicine School of Medicine
    • Interim Chair Medicine School of Medicine
    • M. L. Edwards Family Professor of Pulmonary Medicine
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. David Jacoby is professor of medicine, physiology and pharmacology and chief of pulmonary and critical care medicine at Oregon Health & Science University. He was born in New York, and is a graduate of Princeton University and New York Medical College. He was a resident and chief resident in internal medicine at Temple University Hospital and did his fellowship at the Cardiovascular Research Institute at the University of California, San Francisco. He was a member of the Division of Pulmonary and Critical Care Medicine at Johns Hopkins for 13 years, where he was research director for the division. He moved to OHSU to become division chief in 2003.

Education

  • M.D., New York Medical College, Valhalla New York 1980
  • B.A., Princeton, Princeton New Jersey 1976
  • Residency:

    • Internal medicine, Temple University Hospital, Philadelphia, Pennsylvania, 1981-1983
  • Fellowship:

    • Clinical pulmonary, University of California, San Francisco, 1984-1985
  • Certifications:

    • Diplomate in internal medicine, American Board of Internal Medicine

Publications

  • "Newly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs." American Journal of Physiology - Lung Cellular and Molecular Physiology In: , Vol. 312, No. 6, 05.06.2017, p. L969-L982.
  • "An official American thoracic society research statement : Current challenges facing research and therapeutic advances in airway remodeling." American Journal of Respiratory and Critical Care Medicine  In: , Vol. 195, No. 2, 15.01.2017, p. e4-e19.
  • "Human and mouse eosinophils have antiviral activity against parainfluenza virus." American Journal of Respiratory Cell and Molecular Biology In: , Vol. 55, No. 3, 01.09.2016, p. 387-394.
  • "Toll-Like Receptor 7-Targeted Therapy in Respiratory Disease." Transfusion Medicine and Hemotherapy In: , Vol. 43, No. 2, 01.03.2016, p. 114-119.
  • "The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity." American Journal of Respiratory Cell and Molecular Biology In: , Vol. 53, No. 5, 01.11.2015, p. 738-747.
  • "Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice." Journal of Allergy and Clinical Immunology In: , Vol. 135, No. 2, 01.02.2015, p. 477-487.
  • "Interleukin-1β mediates virus-induced M2 muscarinic receptor dysfunction and airway hyperreactivity." American Journal of Respiratory Cell and Molecular Biology In: , Vol. 51, No. 4, 01.10.2014, p. 494-501.
  • "Interactions of eosinophils with nerves."   Methods in Molecular Biology. Vol. 1178 Humana Press Inc., 2014. p. 215-229 (Methods in Molecular Biology; Vol. 1178).
  • "Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats." American Journal of Respiratory Cell and Molecular Biology In: , Vol. 51, No. 2, 2014, p. 251-261.
  • "Tissue optical clearing, three-dimensional imaging, and computer morphometry in whole mouse lungs and human airways." American Journal of Respiratory Cell and Molecular Biology In: , Vol. 51, No. 1, 2014, p. 43-55.
  • "Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs." PLoS One In: , Vol. 8, No. 9, e75351, 18.09.2013.
  • "Toll-like receptor 7 rapidly relaxes human airways." American Journal of Respiratory and Critical Care Medicine In: , Vol. 188, No. 6, 15.09.2013, p. 664-672.
  • "Toll-like receptor-2/6 and toll-like receptor-9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs." American Journal of Respiratory Cell and Molecular Biology In: , Vol. 48, No. 6, 06.2013, p. 790-796.
  • "Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping." American Journal of Respiratory Cell and Molecular Biology In: , Vol. 48, No. 1, 01.2013, p. 10-16.
  • "Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs." American Journal of Physiology - Lung Cellular and Molecular Physiology In: , Vol. 304, No. 8, 2013.
  • "Eosinophils in Human Disease."   Eosinophils in Health and Disease. Elsevier Inc., 2013. p. 431-536.
  • "Comment." Neuromodulation In: , Vol. 15, No. 6, 11.2012, p. 535-536.
  • "β2-Agonists Inhibit TNF-α-Induced ICAM-1 Expression in Human Airway Parasympathetic Neurons." PLoS One In: , Vol. 7, No. 9, e44780, 25.09.2012.
  • "Upping the antedrug : Is a novel anti-inflammatory Toll-like receptor 7 agonist also a bronchodilator?" British Journal of Pharmacology In: , Vol. 166, No. 2, 05.2012, p. 569-572.
  • "Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma." British Journal of Pharmacology In: , Vol. 165, No. 5, 03.2012, p. 1501-1514.
  • "Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4 +8 - thymocytes and invariant NKT cells but not in Treg cells." PLoS One In: , Vol. 7, No. 2, e31296, 21.02.2012.
  • "The therapeutic potential of toll-like receptor 7 stimulation in Asthma." Inflammation and Allergy - Drug Targets In: , Vol. 11, No. 6, 2012, p. 484-491.
  • "Muscarinic receptor agonists and antagonists : Effects on inflammation and immunity." Handbook of Experimental Pharmacology In: , Vol. 208, 2012, p. 403-427.
  • "Role of TNF-α in virus-induced airway hyperresponsiveness and neuronal M 2 muscarinic receptor dysfunction." British Journal of Pharmacology In: , Vol. 164, No. 2 B, 09.2011, p. 444-452.
  • "Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs." Journal of Allergy and Clinical Immunology In: , Vol. 127, No. 2, 02.2011, p. 462-469.
  • "Three days after a single exposure to ozone, the mechanism of airway hyperreactivity is dependent on substance P and nerve growth factor." American Journal of Physiology - Lung Cellular and Molecular Physiology In: , Vol. 300, No. 2, 02.2011.
  • "Eosinophils increase neuron branching in human and murine skin and in vitro." PLoS One In: , Vol. 6, No. 7, e22029, 2011.
  • "Human mucosal associated invariant T cells detect bacterially infected cells." PLoS Biology In: , Vol. 8, No. 6, 06.2010.
  • "Retinoic acid prevents virus-induced airway hyperreactivity and M receptor dysfunction via anti-inflammatory and antiviral effects." American Journal of Physiology - Lung Cellular and Molecular Physiology In: , Vol. 297, No. 2, 08.2009.
  • "Atropine-enhanced, antigen challenge-induced airway hyperreactivity in guinea pigs is mediated by eosinophils and nerve growth factor." American Journal of Physiology - Lung Cellular and Molecular Physiology In: , Vol. 297, No. 2, 08.2009.

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