Photo of Daniel N. Streblow, Ph.D.

Daniel N. Streblow Ph.D.

    • Associate Professor VGTI-Vaccine and Gene Therapy Institute
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Daniel Streblow received his B.S. in Pharmacology/Toxicology from the University of Wisconsin-Madison in 1992. He graduated from University of Wisconsin-Madison with a Ph.D. in Viral Pathogenesis in 1997. Dr. Streblow received a NIH post-doctoral fellowship and worked with Dr. Jay A. Nelson in the Department of Molecular Microbiology and Immunology at Oregon Health & Science University. He is currently an Associate Scientist at the Vaccine and Gene Therapy Institute and Research Assistant Professor at the Department of Molecular Microbiology and Immunology.

The focus of the Streblow laboratory is on defining the role of human cytomegalovirus (HCMV) in the development of vascular disease and chronic rejection of organ allografts. The role of CMV in these diseases is still uncharacterized. Dr. Streblow's lab studies the following topics: 1) Determining the mechanisms of HCMV-accelerated vascular disease through identification of the viral genes expressed during these diseases using a HCMV microarray chip developed by Dr. Streblow's laboratory in combination with the Shared Microarray Core at VGTI. Once identified, the function of these viral genes will be examined using in vitro and in vivo models of CMV-accelerated vascular disease. 2) Determining the mechanisms of CMV-accelerated vascular disease in both mouse models of atherosclerosis and rat organ transplantation models using a DNA microarray approach. The Streblow lab in conjunction with Dr. Susan Orloff’s laboratory at OHSU has determined RCMV in vivo gene expression in infected rats and has begun functional studies of these genes. 3) Determine viral and host gene expression during the development of atherosclerosis and transplant vascular sclerosis, the vascular lesion associated with chronic allograft rejection 4) determining the mechanisms of viral acceleration of chronic allograft rejection from latently infected donor, which is the most common cause of HCMV-associated disease in transplant patients associated with expression during the different stages of viremia associated with CMV including 5) Determining the function of CMV-encoded chemokine receptors in the context of viral pathogenesis and acceleration of vascular disease. Dr. Streblow's lab has also generated a rhesus macaque (RM) chikungunya virus (CHIKV) infection animal model to identify correlates of CHIKV pathogenesis and to test novel antivirals and vaccines. They are working on developing a Zika virus RM model.

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Areas of interest

  • CMV pathogenesis and transplantation

Education

  • B.S., University of Wisconsin, Madison Wisconsin United States 1992
  • Ph.D., University of Wisconsin, Madison Wisconsin United States 1997

Publications

Selected publications

  • Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ,Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, DucoreRM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R,Wiley CA, Nelson JA, Streblow DN. Zika Virus infection of rhesus macaques leadsto viral persistence in multiple tissues. PLoS Pathog. 2017 Mar9;13(3):e1006219. doi: 10.1371/journal.ppat.1006219. [PMID: 28278237]

  • Haese NN, Broeckel RM, Hawman DW, Heise MT, Morrison TE,Streblow DN. Animal Models of Chikungunya Virus Infection and Disease. J InfectDis. 2016 Dec 15;214(suppl 5):S482-S487. [PMID: 27920178]

  • Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB,Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A,Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ,Früh K, Sacha JB. Cross-Species Rhesus Cytomegalovirus Infection of CynomolgusMacaques. PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi:10.1371/journal.ppat.1006014.[PMID: 27829026]

  • Caviness K, Bughio F, Crawford LB, Streblow DN, Nelson JA,Caposio P, Goodrum F. Complex Interplay of the UL136 Isoforms BalancesCytomegalovirus Replication and Latency. MBio. 2016 Mar 1;7(2):e01986. doi:10.1128/mBio.01986-15.[PMID: 26933055]

Publications

  • "Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology." Nature Communications In: , Vol. 9, No. 1, 263, 01.12.2018.
  • "In utero administration of drugs targeting microglia improves the neurodevelopmental outcome following cytomegalovirus infection of the rat fetal brain." Frontiers in Cellular Neuroscience  In: , Vol. 12, 55, 06.03.2018.
  • "Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway." Journal of Virology  In: , Vol. 92, No. 6, e01913-17, 01.03.2018.
  • "Human cytomegalovirus induces cellular and humoral virus-specific immune responses in humanized BLT mice." Scientific Reports  In: , Vol. 7, No. 1, 937, 01.12.2017.
  • "Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques." PLoS Neglected Tropical Diseases In: , Vol. 11, No. 6, e0005637, 19.06.2017.
  • "A novel agonist of the trif pathway induces a cellular state refractory to replication of Zika, Chikungunya, and dengue viruses." mBio In: , Vol. 8, No. 3, e00452-17, 01.05.2017.
  • "Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues." PLoS Pathogens In: , Vol. 13, No. 3, e1006219, 01.03.2017.
  • "Animal models of chikungunya virus infection and disease." Journal of Infectious Diseases In: , Vol. 214, 01.12.2016, p. S482-S487.
  • "Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months." Nature Communications  In: , Vol. 7, 13520, 30.11.2016.
  • "Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques." PLoS Pathogens In: , Vol. 12, No. 11, e1006014, 01.11.2016.
  • "Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus." PLoS Pathogens  In: , Vol. 12, No. 10, e1005891, 01.10.2016.
  • "Complex interplay of the UL136 isoforms balances cytomegalovirus replication and Latency." mBio  In: , Vol. 7, No. 2, e01986-15, 01.03.2016.
  • "Cytomegalovirus Infection of the Rat Developing Brain In Utero Prominently Targets Immune Cells and Promotes Early Microglial Activation." PloS one  In: , Vol. 11, No. 7, 2016, p. e0160176.
  • "Nonhuman primate models of chikungunya virus infection and disease (CHIKV NHP model)." Pathogens In: , Vol. 4, No. 3, 16.09.2015, p. 662-681.
  • "Rat cytomegalovirus vaccine prevents accelerated chronic rejection in CMV-Naïve recipients of infected donor allograft hearts." American Journal of Transplantation In: , Vol. 15, No. 7, 01.07.2015, p. 1805-1816.
  • "Humanized mouse models of human cytomegalovirus infection." Current Opinion in Virology  In: , Vol. 13, 29.06.2015, p. 86-92.
  • "Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway." PLoS Pathogens In: , Vol. 11, No. 5, e1004881, 01.05.2015.
  • "Sequence-specific modifications enhance the broad-spectrum antiviral response activated by RIG-I agonists." Journal of Virology  In: , Vol. 89, No. 15, 2015, p. 8011-8025.
  • "Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses." PLoS Pathogens In: , Vol. 11, No. 12, e1005324, 2015.
  • "HCMV Infection of Humanized Mice after Transplantation of G-CSF-Mobilized Peripheral Blood Stem Cells from HCMV-Seropositive Donors." Biology of Blood and Marrow Transplantation In: , Vol. 20, No. 1, 01.2014, p. 132-135.
  • "Cytomegalovirus pp65 limits dissemination but is dispensable for persistence." Journal of Clinical Investigation  In: , Vol. 124, No. 5, 2014, p. 1928-1944.
  • "Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes." Journal of Virology In: , Vol. 88, No. 15, 2014, p. 8213-8226.
  • "Human cytomegalovirus induces upregulation of arginase II : Possible implications for vasculopathies." Basic Research in Cardiology  In: , Vol. 109, No. 2, 401, 2014.
  • "Fluorescence-based laser capture microscopy technology facilitates identification of critical in vivo cytomegalovirus transcriptional programs." Methods in Molecular Biology In: , Vol. 1119, 2014, p. 217-237.
  • "Chikungunya Virus Infection Results in Higher and Persistent Viral Replication in Aged Rhesus Macaques Due to Defects in Anti-Viral Immunity." PLoS Neglected Tropical Diseases In: , Vol. 7, No. 7, e2343, 07.2013.
  • "Cytomegalovirus CC chemokine promotes immune cell migration." Journal of Virology In: , Vol. 86, No. 21, 11.2012, p. 11833-11844.
  • "A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection." PLoS Pathogens  In: , Vol. 7, No. 12, e1002444, 12.2011.
  • "Simian varicella virus gene expression during acute and latent infection of rhesus macaques." Journal of NeuroVirology  In: , Vol. 17, No. 6, 12.2011, p. 600-612.
  • "The role of cytomegalovirus in angiogenesis." Virus Research In: , Vol. 157, No. 2, 05.2011, p. 204-211.
  • "IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin." Blood  In: , Vol. 117, No. 1, 06.01.2011, p. 352-361.

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