Photo of Daniel L. Marks, M.D., Ph.D.

Daniel L. Marks M.D., Ph.D.

    • Professor of Pediatrics School of Medicine
    • Credit Union for Kids Professor of Pediatric Research Pediatrics School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Physiology and Pharmacology Graduate Program School of Medicine

Dr. Marks' special interests are weight regulation in children, particulary involuntary weight loss or poor growth in chronic dieseases (cachexia, failure to thrive). His clinical areas of interest are all aspects of pediatric endocrinology (including growth, puberty, thyroid, diabetes and adrenal disorders), pediatric obesity and failure to thrive.

Dr. Marks received both his medical degree and Ph.D. in 1995 from the University of Washington in Seattle. Dr. Marks completed his residency at the University of Utah, SLC in 1998, followed by a fellowship in pediatric endocrinology at Oregon Health & Science University in 2001. Dr. Marks is currently the Associate Director of the OHSU MD, PhD program, Director of the Patient Resiliency Program for the Brenden-Colson Center for Pancreatic Care and the Director of the Department of Pediatrics Fellowship Program at Oregon Health & Science University in Portland, OR. Dr. Marks also serves as a Consulting Senior Scientific Advisor for the Bill & Melinda Gates Foundation.

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Education

  • M.D., University of Washington, Seattle Washington 1995
  • Ph.D., University of Washington School of Medicine, Seattle Washington 1993
  • Residency:

    • University of Utah, Salt Lake City, Utah
  • Fellowship:

    • Pediatric endocrinology, Oregon Health & Science University, 1998-2001
  • Certifications:

    • American Academy of Pediatrics

Memberships and associations

  • Oregon State Medical Society

Publications

  • "A life without hunger : The Ups (and downs) to modulating melanocortin-3 receptor signaling." Frontiers in Neuroscience In: , Vol. 11, No. MAR, 128, 16.03.2017.
  • "Melanocortin-3 receptors expressed in Nkx2.1(+ve) neurons are sufficient for controlling appetitive responses to hypocaloric conditioning." Scientific Reports In: , Vol. 7, 44444, 15.03.2017.
  • "Dexamethasone chemotherapy does not disrupt orexin signaling." PLoS ONE In: , Vol. 11, No. 12, e0168731, 01.12.2016.
  • "Mesenchymal stromal cell-derived extracellular vesicles promote myeloid-biased multipotent hematopoietic progenitor expansion via toll-like receptor engagement." Journal of Biological Chemistry  In: , Vol. 291, No. 47, 18.11.2016, p. 24607-24617.
  • "Hypothalamic Dysfunction and Multiple Sclerosis : Implications for Fatigue and Weight Dysregulation." Current Neurology and Neuroscience Reports In: , Vol. 16, No. 11, 98, 01.11.2016.
  • "A distinct brain pathway links viral RNA exposure to sickness behavior." Scientific Reports In: , Vol. 6, 29885, 20.07.2016.
  • "Leukemia inhibitory factor as a mediator of lipopolysaccharide effects on appetite and selected hormones and metabolites." Journal of Animal Science In: , Vol. 94, No. 7, 01.07.2016, p. 2789-2797.
  • "Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss." Molecular Metabolism In: , 01.04.2016.
  • "Hypothalamic inflammation and food intake regulation during chronic illness." Peptides In: , Vol. 77, 01.03.2016, p. 60-66.
  • "RHEB1 expression in embryonic and postnatal mouse." Histochemistry and Cell Biology In: , 26.12.2015, p. 1-12.
  • "Defense of elevated body weight setpoint in Diet-Induced obese rats on low energy diet is mediated by loss of melanocortin sensitivity in the paraventricular hypothalamic nucleus." PLoS One In: , Vol. 10, No. 10, e0139462, 07.10.2015.
  • "The central role of hypothalamic inflammation in the acute illness response and cachexia." Seminars in Cell and Developmental Biology In: , 17.08.2015.
  • "Maternal high-fat diet and obesity compromise fetal hematopoiesis." Molecular Metabolism In: , Vol. 4, No. 1, 01.01.2015, p. 25-38.
  • "Neonatal estrogen exposure results in biphasic age-dependent effects on the skeletal development of male mice." Endocrinology In: , Vol. 156, No. 1, 01.01.2015, p. 193-202.
  • "The regulation of muscle mass by endogenous glucocorticoids." Frontiers in Physiology In: , Vol. 6, No. FEB, 12, 2015.
  • "Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity." Obesity In: , Vol. 22, No. 10, 01.10.2014, p. 2109-2114.
  • "Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle." PLoS One In: , Vol. 9, No. 9, e106489, 25.09.2014.
  • "Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke." PLoS One In: , Vol. 9, No. 5, e97529, 13.05.2014.
  • "A role for orexin in cytotoxic chemotherapy-induced fatigue." Brain, Behavior, and Immunity In: , Vol. 37, 03.2014, p. 84-94.
  • "Adipose tissue NK cells manifest an activated phenotype in human obesity." Metabolism: Clinical and Experimental In: , Vol. 62, No. 11, 11.2013, p. 1557-1561.
  • "Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 33, No. 10, 10.2013, p. 1650-1656.
  • "Missense mutation in mouse GALC mimics human gene defect and offers new insights into krabbe disease." Human Molecular Genetics In: , Vol. 22, No. 17, ddt190, 09.2013, p. 3397-3414.
  • "Cancer- and endotoxin-induced cachexia require intact glucocorticoid signaling in skeletal muscle." FASEB Journal In: , Vol. 27, No. 9, 09.2013, p. 3572-3582.
  • "Hexosamine Biosynthesis Is a Possible Mechanism Underlying Hypoxia's Effects on Lipid Metabolism in Human Adipocytes." PLoS One In: , Vol. 8, No. 8, e71165, 14.08.2013.
  • "Pancreatic inflammation and increased islet macrophages in insulin-resistant juvenile primates." Journal of Endocrinology In: , Vol. 217, No. 2, 05.2013, p. 207-213.
  • "Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques." Diabetes In: , Vol. 62, No. 2, 02.2013, p. 490-497.
  • "Hyperglycemia slows embryonic growth and suppresses cell cycle via cyclin D1 and p21." Diabetes In: , Vol. 62, No. 1, 01.2013, p. 234-242.
  • "Hypothalamic signaling in anorexia induced by indispensable amino acid deficiency." American Journal of Physiology - Endocrinology and Metabolism In: , Vol. 303, No. 12, 15.12.2012.
  • "Perinatal Exposure to a High-Fat Diet Is Associated with Reduced Hepatic Sympathetic Innervation in One-Year Old Male Japanese Macaques." PLoS One In: , Vol. 7, No. 10, e48119, 30.10.2012.
  • "Expression of myeloid differentiation factor 88 in neurons is not requisite for the induction of sickness behavior by interleukin-1β." Journal of Neuroinflammation In: , Vol. 9, 229, 03.10.2012.

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