My main research interest involves “biobehavioral profiling” of adults with chronic cardiovascular disease in general and with advanced heart failure in particular. This innovative research process, informed by extensive interdisciplinary training and collaboration, employs advanced statistical techniques to mine heterogeneous responses to heart failure and identify patient subgroups that are particularly vulnerable to poor clinical outcomes and quality-of-life. My prior research (1F31NR010299) has informed how favorable self-care behaviors are associated with better intermediary (biomarkers of systemic inflammation and myocardial stress, and intra-thoracic impedance parameters), humanistic (health status), economic (direct inpatient cost), and clinical outcomes (event-free survival). My current clinical research focuses on characterizing gender differences in physical and psychological symptom profiles (K12HD043488), identifying favorable patterns of self-care behaviors over time among adults with heart failure (11BGIA7840062), and identifying common and distinct trajectories of change in symptoms and pathogenic biomarkers in heart failure patients undergoing the advanced therapy of mechanical circulatory support (1R01NR013492). Unexplained heterogeneity in response to heart failure impedes our ability to predict favorable outcomes, provide adequate patient and family education and anticipatory guidance, and personalize monitoring and management strategies. Findings from my past, current, and planned research will lead seamlessly to the development of a new breed of interventions in heart failure that are tailored to observed biobehavioral profiles.
- M.S.N., Univ. of Pennsylvania School of Nursing, Philadelphia Pennsylvania United States 2005
- Ph.D., Univ. of Pennsylvania School of Nursing, Philadelphia Pennsylvania United States 2009
- B.S.N., University of New Hampshire School of Nursing New Hampshire United States 1996
- Post-Doctoral Fellowship, University of Arizona College of Pharmacy 2010