Photo of Christina A. Harrington, Ph.D.

Christina A. Harrington Ph.D.

  • (503) 418-2737
    • Research Associate Professor IG.Integrated Genomics
    • Cancer Biology Graduate Program School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine

Dr. Harrington is Director of the Affymetrix Microarray Core, a core unit of the Gene Microarray Shared Resource (GMSR) at OHSU.  Dr. Harrington has worked in the DNA microarray field for the past 12 years.  She was employed at Affymetrix from 1997 through October, 2000, as a Senior Staff Scientist and Manager of the Scientific Liaison Group.  In this capacity she was involved in the development of the GeneChip array expression profiling application and was responsible for the direction of the Affymetrix Academic User Center, a program of research collaborations with academic investigators.  Prior to her position at Affymetrix, Dr. Harrington worked in the field of molecular neurobiology, most recently as a Research Officer at the Garvan Institute for Medical Research, Sydney, Australia, and prior to that as a Principal Research Fellow in the Laboratory for Molecular Pharmacology, University College, London, United Kingdom.  Dr. Harrington has a PhD in Molecular, Cellular and Developmental Biology from the University of Colorado, Boulder, and a BS in Biology from California Institute of Technology.  Currently, Dr. Harrington is Co-Chair of the Microarray Research Group of the Association of Biomolecular Resource Facilities.Dr. Harrington has collaborated with many research groups at OHSU and elsewhere in the last 8 years in the application of DNA microarrays to important problems in biomedical research.

Publications

  • "MicroRNAs in human cerebrospinal fluid as biomarkers for Alzheimer's disease." Journal of Alzheimer's Disease In: , Vol. 55, No. 3, 2017, p. 1223-1233.
  • "Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice." Genes, Brain and Behavior In: , 2017.
  • "MicroRNA signatures of colonic polyps on screening and histology." Cancer Prevention Research In: , Vol. 9, No. 12, 01.12.2016, p. 942-949.
  • "AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB." Science Signaling  In: , Vol. 9, No. 444, ra88, 06.09.2016.
  • "Molecular diagnosis : Implications for ophthalmology." Progress in Retinal and Eye Research In: , Vol. 50, 01.01.2016, p. 25-33.
  • "Orbital pseudotumor can be a localized form of granulomatosis with polyangiitis as revealed by gene expression profiling." Experimental and Molecular Pathology In: , Vol. 99, No. 2, 01.10.2015, p. 271-278.
  • "Fibrosis, gene expression and orbital inflammatory disease." British Journal of Ophthalmology In: , Vol. 99, No. 10, 01.10.2015, p. 1424-1429.
  • "The role of the immune response in the pathogenesis of thyroid eye disease : A reassessment." PLoS One In: , Vol. 10, No. 9, e0137654, 15.09.2015.
  • "Parallel gene expression changes in sarcoidosis involving the lacrimal gland, orbital tissue, or blood." JAMA Ophthalmology In: , Vol. 133, No. 7, 01.07.2015, p. 770-777.
  • "Molecular diagnosis of orbital inflammatory disease." Experimental and Molecular Pathology In: , Vol. 98, No. 2, 01.04.2015, p. 225-229.
  • "Dual-Trait Selection for Ethanol Consumption and Withdrawal : Genetic and Transcriptional Network Effects." Alcoholism: Clinical and Experimental Research In: , Vol. 38, No. 12, 01.12.2014, p. 2915-2924.
  • "Lgg4 immunostaining and its implications in orbital inflammatory disease." PLoS One In: , Vol. 9, No. 10, e10984, 10.10.2014.
  • "Computational detection of alternative exon usage." Frontiers in Neuroscience In: , No. MAY, Article 69, 2011.
  • "Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth." PLoS One In: , Vol. 6, No. 7, e21754, 2011.
  • "A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib." Blood  In: , Vol. 115, No. 2, 14.01.2010, p. 315-325.
  • "TLR8-dependent TNF-α overexpression in Fanconi anemia group C cells." Blood In: , Vol. 114, No. 26, 17.12.2009, p. 5290-5298.
  • "Use of bioanalyzer electropherograms for quality control and target evaluation in microarray expression profiling studies of ocular tissues." Journal of Ocular Biology, Diseases, and Informatics  In: , Vol. 2, No. 4, 12.2009, p. 243-249.
  • "Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles." Arthritis Research and Therapy In: , Vol. 11, No. 6, R168, 09.11.2009.
  • "High throughput sequencing in mice : A platform comparison identifies a preponderance of cryptic SNPs." BMC Genomics In: , Vol. 10, 1471, 17.08.2009, p. 379.
  • "Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke : A critical role for IRF3." Journal of Neuroscience In: , Vol. 29, No. 31, 05.08.2009, p. 9839-9849.
  • "Hypothesis : Sarcoidosis is a STAT1-mediated disease." Clinical Immunology In: , Vol. 132, No. 2, 08.2009, p. 174-183.
  • "Gene expression profiling of whole blood : Comparison of target preparation methods for accurate and reproducible microarray analysis." BMC Genomics In: , Vol. 10, 2, 05.01.2009.
  • "Application of biostatistics and bioinformatics tools to identify putative transcription factor-gene regulatory network of ankylosing spondylitis and sarcoidosis." Communications in Statistics - Theory and Methods In: , Vol. 38, No. 18, 2009, p. 3326-3338.
  • "Expression profiling of the ovarian surface kinome reveals candidate genes for early neoplastic changes." Translational Oncology In: , Vol. 2, No. 4, 2009, p. 341-349.
  • "Randomization in laboratory procedure is key to obtaining reproducible microarray results." PLoS One In: , Vol. 3, No. 11, e3724, 14.11.2008.
  • "Translational gene mapping of cognitive decline." Neurobiology of Aging In: , Vol. 29, No. 4, 04.2008, p. 524-541.
  • "Gene expression profiling in ischemic brain injury and ischemic tolerance."  Handbook of Neurochemistry and Molecular Neurobiology: Acute Ischemic Injury and Repair in the Nervous System. Springer US, 2007. p. 1-17.
  • "In chronic myeloid leukemia white cells from cytogenetic responders and non-responders to imatinib have very similar gene expression signatures." Haematologica  In: , Vol. 90, No. 4, 04.2005, p. 459-464.
  • "Erratum : On the integration of alcohol-related quantitative trait loci and gene expression analyses (Alcoholism: Clinical and Experimental Research 28:10 (1437-1444))." Alcoholism: Clinical and Experimental Research  In: , Vol. 28, No. 12, 12.2004, p. 1930.
  • "On the integration of alcohol-related quantitative trait loci and gene expression analyses." Alcoholism: Clinical and Experimental Research  In: , Vol. 28, No. 10, 10.2004, p. 1437-1448.

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