Photo of Cadence True, Ph.D.

Cadence True Ph.D.

  •      (503) 346-5380
    • Research Assistant Professor Oregon National Primate Research Center

Cadence True obtained her PhD in Neuroscience from OHSU in 2012 before becoming a fellow at the Reproductive Endocrine Unit at Massachusetts General Hospital. In 2014 she returned to OHSU and in 2016 accepted a position as a Research Assistant Professor in the Division of Cardiometabolic Health. Her research focuses on understanding how changes in metabolic environments, both undernutrition and obesity, alter neuronal populations in the hypothalamus that regulate body weight and fertility. Specifically, her work investigates how maternal obesity programs the offspring brain leading to an increased risk of metabolic dysfunction for that individual later in life.  She also collaborates within a National Translation Center for Research in Infertility (NCTRI) supported by the Eunice Kennedy Shriver National Institute of Child Health and Development investigating how early obesity contributes to polycystic ovary syndrome (PCOS), the leading cause of infertility in American women. In addition to academic research, Dr. True is an advocate of science outreach and participates in many public science events including the Science on Tap series, Portland Community College Science Café series and Oregon Nutrition Day, where she has addressed a variety of topics including obesity, the importance of maternal nutrition for offspring development and polycystic ovary syndrome.

Areas of interest

  • Polycystic ovary syndrome
  • Developmental origins of health and diseases
  • Obesity/Type 2 diabetes
  • Reproductive neuroendocrinology

Education

  • Ph.D., Oregon Health & Science University 2002
  • Fellowship:

    • Postdoctoral fellow at Harvard Medical School, Massachusetts General Hospital, Boston MA

Memberships and associations

  • The Endocrine Society 2009-present

Publications

  • True CA, Takahashi D, Burns SE, Mishler EC, Bond KR, Wilcox MC, Calhoun AR, Bader LA, Dean TA, Ryan ND, Slayden OD, Cameron JL, Stouffer RL. “Chronic Combined Hyperandrogenemia and Western-style Diet in young Female Rhesus Macaques Causes Greater Metabolic Impairments Compared to Either Treatment Alone.” Human Reproduction. In press.

  • True C, Takahashi D, Kirigiti M, Lindsley R, Moctezuma C, Arik A, Smith MS, Kievit P, Grove K. “Arcuate nucleus neuropeptide coexpression and connections to gonadotropin-releasing hormone neurons in the female rhesus macaque.” Journal of Neuroendocrinology, 2017(29.

  • True C, Alam SN, Cox K, Chan YM, Seminara SB.  “Neurokinin B is critical for normal timing of     sexual maturation but dispensable for adult reproductive function in female mice.” Endocrinology, 2015 (156): 1386-1397.

  • True C, Verma S, Grove KL, Smith MS. “Cocaine- and amphetamine-regulated transcript is a potent stimulator of GnRH and Kisspeptin cells and may contribute to negative energy balance-induced reproductive inhibition in females.” Endocrinology, 2013 (154): 2821-2823.

  • True C, Kirigiti M, Ciofi P, Grove KL and Smith MS. “Characterization of Arcuate Nucleus Kisspeptin/Neurokinin B Neuronal Projections and Regulation during Lactation in the Rat” Journal of Neuroendocrinology, 2011 (23): 52-64.

  • True CA, Takahashi D, Burns SE, Mishler EC, Bond KR, Wilcox MC, Calhoun AR, Bader LA, Dean TA, Ryan ND, Slayden OD, Cameron JL, Stouffer RL. “Chronic Combined Hyperandrogenemia and Western-style Diet in young Female Rhesus Macaques Causes Greater Metabolic Impairments Compared to Either Treatment Alone.” Human Reproduction. In press.

  • True C, Takahashi D, Kirigiti M, Lindsley R, Moctezuma C, Arik A, Smith MS, Kievit P, Grove K. “Arcuate nucleus neuropeptide coexpression and connections to gonadotropin-releasing hormone neurons in the female rhesus macaque.” Journal of Neuroendocrinology, 2017(29).

  • Sullivan E, Rivera H, True C, Franco J, Baquero K, Dean T, Valleau J, Takahashi D, Frazee T, Hanna G, Kirigiti M, Bauman L, Grove K, Kievit P. "Maternal and Postnatal High-Fat Diet Consumption Programs Energy Balance and Hypothalamic Melanocortin Signaling in Nonhuman Primate Offspring" American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 2017 In press.

  • Heppner K, Baquero A, Bennett C, Lindsley SR, Kirigiti M, Bennett B, Bosch M, Ronnekleiv O, True C, Grove K, Smith MS.  “GLP-1R signaling directly activates arcuate nucleus kisspeptin action but does not rescue LH inhibition during negative energy balance.” eNeuro 2017.  

  • True C, Alam SN, Cox K, Chan YM, Seminara SB.  “Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice.” Endocrinology, 2015 (156): 1386-1397.

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