Photo of Brian Johnstone, Ph.D., FORS

Brian Johnstone Ph.D., FORS

    • Adjunct Professor of Orthopaedics and Rehabilitation School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Education

  • B.S., Brunel University, Middlesex 1983
  • Ph.D., University of London; Kennedy Institute 1987

Honors and awards

  • Dr. Johnstone received the Marshall R. Urist MD Award in 2017. This prestigious award, sponsored by the Journal of Orthopaedic Research (JOR), honors an investigator who has established him/herself as a cutting-edge researcher in tissue regeneration research and has done so with a sustained ongoing body of focused research in the area of tissue regeneration as it relates to the musculoskeletal system.
  • In March 2018, Dr. Johnstone was inducted into the inaugural class of ORS Fellows. The ORS Fellows Program recognizes individuals who have demonstrated service and leadership, substantial achievement, expert knowledge, and significant contributions to the field of musculoskeletal research and the Orthopaedic Research Society (ORS). Fellows represent the ORS as the thought leaders and topic experts in their respective disciplines. Fellows will also serve as role models in the ORS membership community and in the field of musculoskeletal research.

Publications

  • "Physioxia Promotes the Articular Chondrocyte-Like Phenotype in Human Chondroprogenitor-Derived Self-Organized Tissue." Tissue Engineering - Part A  In: , Vol. 24, No. 3-4, 01.02.2018, p. 264-274.
  • "Dynamic mechanical compression of chondrocytes for tissue engineering : A critical review." Frontiers in Bioengineering and Biotechnology  In: , Vol. 5, No. DEC, 76, 11.12.2017.
  • "Responses to altered oxygen tension are distinct between human stem cells of high and low chondrogenic capacity." Stem Cell Research and Therapy  In: , Vol. 7, No. 1, 154, 20.10.2016.
  • "Use of MicroRNA biomarkers to distinguish enchondroma from low-grade chondrosarcoma." Connective Tissue Research  In: , 30.06.2016, p. 1-7.
  • "Alterations in acute myeloid leukaemia bone marrow stromal cell exosome content coincide with gains in tyrosine kinase inhibitor resistance." British Journal of Haematology  In: , Vol. 172, No. 6, 01.03.2016, p. 983-986.
  • "Reoxygenation enhances tumour necrosis factor alpha-induced degradation of the extracellular matrix produced by chondrogenic cells." European Cells and Materials  In: , Vol. 31, 01.01.2016, p. 425-439.
  • "Hypoxia-inducible factor 3-alpha expression is associated with the stable chondrocyte phenotype." Journal of Orthopaedic Research  In: , Vol. 33, No. 11, 01.11.2015, p. 1561-1570.
  • "Effectiveness of posterolateral lumbar fusion varies with the physical properties of demineralized bone matrix strip." Asian Spine Journal In: , Vol. 9, No. 3, 2015, p. 433-439.
  • "Transforming growth factor beta-releasing scaffolds for cartilage tissue engineering." Tissue Engineering - Part B: Reviews  In: , Vol. 20, No. 2, 01.04.2014, p. 106-125.
  • "Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation." Journal of Bone and Mineral Research In: , Vol. 29, No. 5, 2014, p. 1269-1282.
  • "Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes." Arthritis Research and Therapy  In: , Vol. 15, No. 4, R92, 21.08.2013.
  • "Evaluation of a Novel Spine and Surface Topography System for Dynamic Spinal Curvature Analysis during Gait." PLoS One  In: , Vol. 8, No. 7, e70581, 23.07.2013.
  • "Tissue engineering for articular cartilage repair - The state of the art." European Cells and Materials In: , Vol. 25, 2012, p. 248-267.
  • "Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels." European Cells and Materials In: , Vol. 22, 12.2011, p. 43-55.
  • "A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells." FASEB Journal  In: , Vol. 25, No. 5, 05.2011, p. 1486-1496.
  • "A novel bioreactor for the dynamic stimulation and mechanical evaluation of multiple tissue-engineered constructs." Tissue Engineering - Part C: Methods  In: , Vol. 17, No. 3, 01.03.2011, p. 367-374.
  • "Temporal exposure to chondrogenic factors modulates human mesenchymal stem cell chondrogenesis in hydrogels." Tissue Engineering - Part A  In: , Vol. 17, No. 3-4, 01.02.2011, p. 371-380.
  • "Characterization of esterified hyaluronan-gelatin polymer composites suitable for chondrogenic differentiation of mesenchymal stem cells." Journal of Biomedical Materials Research - Part A  In: , Vol. 91, No. 2, 11.2009, p. 416-427.
  • "Stem cells for cartilage regeneration." European Cells and Materials  In: , Vol. 18, No. SUPPL. 1, 08.2009, p. 26.
  • "Evaluation criteria for musculoskeletal and craniofacial tissue engineering constructs : A conference report." Tissue Engineering - Part A  In: , Vol. 14, No. 12, 01.11.2008, p. 2089-2104.
  • "Cell sources for cartilage tissue engineering." European Cells and Materials  In: , Vol. 16, No. SUPPL.2, 07.2008, p. 40.
  • "Stem cell based tissue engineering for meniscus repair." Journal of Biomedical Materials Research - Part A  In: , Vol. 85, No. 2, 05.2008, p. 445-455.
  • "Expression of two novel alternatively spliced COL2A1 isoforms during chondrocyte differentiation." Matrix Biology In: , Vol. 27, No. 3, 04.2008, p. 254-266.
  • "α10 Integrin expression is up-regulated on fibroblast growth factor-2-treated mesenchymal stem cells with improved chondrogenic differentiation potential." Stem Cells and Development  In: , Vol. 16, No. 6, 01.12.2007, p. 965-978.
  • "Design and characterization of poly(ethylene glycol) photopolymerizable semi-interpenetrating networks for chondrogenesis of human mesenchymal stem cells." Tissue Engineering  In: , Vol. 13, No. 10, 01.10.2007, p. 2549-2560.
  • "Discussion with reviewers." European Cells and Materials  In: , Vol. 14, 07.2007, p. 90-91.
  • "A bridging demineralized bone implant facilitates posterolateral lumbar fusion in New Zealand White rabbits." Spine In: , Vol. 32, No. 1, 01.2007, p. 36-41.
  • "Discussion with reviewers." European Cells and Materials In: , Vol. 13, 01.2007, p. 99.
  • "Skeletal tissue regeneration with stem cells." European Cells and Materials  In: , Vol. 12, No. SUPPL.1, 08.2006, p. 35.
  • "Ascorbate-enhanced chondrogenesis of ATDC5 cells." European Cells and Materials  In: , Vol. 12, 07.2006, p. 64-69.

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