Dr. Nagel is an Professor of Psychiatry and Behavioral Neuroscience at Oregon Health & Science University, where she serves as the Vice Chair for Research in the Department of Psychiatry, directs the Developmental Brain Imaging Laboratory, and is the Director of pediatric neuropsychology and a practicing neuropsychologist within the Division of Child and Adolescent Psychiatry. Dr. Nagel's research focuses on adolescent brain and cognitive development in healthy and at-risk populations. Her work has primarily focused on understanding the development of executive, emotional, and reward-based networks in the brain using neuroimaging and how perturbations to these systems may result in a heightened vulnerability for mental illness during the adolescent years. More specifically, her lab has been conducting longitudinal neuroimaging studies of Portland-area youth for the past 10 years, with aims toward identifying neurobiological markers of risk and resilience for psychopathology, including addiction, and hopes of ultimately informing more targeted intervention and prevention efforts. She is a Principal Investigator on several federally-funded National multi-site projects toward that end, including the National Consortium on Alcohol & Neurodevelopment in Adolescence (NCANDA) and the recently funded Adolescent Brain Cognitive Development Study (ABCD).
Dr. Nagel has extensive experience in the neuropsychological evaluation of children and adolescents referred for a variety of conditions, including epilepsy, learning disabilities, traumatic brain injury, genetic/metabolic abnormalities, brain tumors, and attention problems. Dr. Nagel's primary research focuses on exploring typical adolescent brain and cognitive development using structural and functional neuroimaging and neuropsychological assessment techniques. Additionally, Dr. Nagel has applied her research findings and methodologies from her studies of normally developing youth to other populations, including pediatric cancer survivors and adolescents with substance abuse disorders. Dr. Nagel has published several peer-reviewed articles in the area of child and adolescent cognition and brain development, serves as an ad-hoc reviewer for several scholarly journals, and regularly attends and presents at professional conferences. Dr. Nagel has also been involved with teaching and supervision of undergraduate, graduate, and medical students.Read more
- B.S., Washington State University, Pullman Washington United States 1995
- Ph.D., University of Memphis, Memphis Tennessee United States 2003
- NIMH post-doctoral fellow, biological psychiatry and neuroscience, UCSD, 2003-05
- "Ventral striatal response during decision making involving risk and reward is associated with future binge drinking in adolescents." Neuropsychopharmacology In: , 07.05.2018, p. 1-7.
- "Adolescent gender differences in cognitive control performance and functional connectivity between default mode and fronto-parietal networks within a self-referential context." Frontiers in Behavioral Neuroscience In: , Vol. 12, 73, 23.04.2018.
- "Altered brain developmental trajectories in adolescents after initiating drinking." American Journal of Psychiatry In: , Vol. 175, No. 4, 01.04.2018, p. 370-380.
- "Adolescent neurocognitive development and impacts of substance use : Overview of the adolescent brain cognitive development (ABCD) baseline neurocognition battery." Developmental Cognitive Neuroscience In: , 01.01.2018.
- "Convergent neurobiological predictors of emergent psychopathology during adolescence." Birth Defects Research In: , Vol. 109, No. 20, 01.12.2017, p. 1613-1622.
- "Adolescent executive dysfunction in daily life : Relationships to risks, brain structure and substance use." Frontiers in Behavioral Neuroscience In: , Vol. 11, 223, 13.11.2017.
- "Real-time motion analytics during brain MRI improve data quality and reduce costs." NeuroImage In: , Vol. 161, 01.11.2017, p. 80-93.
- "Structural brain anomalies in healthy adolescents in the NCANDA cohort : relation to neuropsychological test performance, sex, and ethnicity." Brain Imaging and Behavior In: , Vol. 11, No. 5, 01.10.2017, p. 1302-1315.
- "Reduced fronto-amygdalar connectivity in adolescence is associated with increased depression symptoms over time." Psychiatry Research - Neuroimaging In: , Vol. 266, 30.08.2017, p. 35-41.
- "Binge drinking and family history of alcoholism are associated with an altered developmental trajectory of impulsive choice across adolescence." Addiction In: , Vol. 112, No. 7, 01.07.2017, p. 1184-1192.
- "Eveningness and Later Sleep Timing Are Associated with Greater Risk for Alcohol and Marijuana Use in Adolescence : Initial Findings from the National Consortium on Alcohol and Neurodevelopment in Adolescence Study." Alcoholism: Clinical and Experimental Research In: , Vol. 41, No. 6, 01.06.2017, p. 1154-1165.
- "Effects of prior testing lasting a full year in NCANDA adolescents : Contributions from age, sex, socioeconomic status, ethnicity, site, family history of alcohol or drug abuse, and baseline performance." Developmental Cognitive Neuroscience In: , Vol. 24, 01.04.2017, p. 72-83.
- "Adolescent neural response to reward is related to participant sex and task motivation." Brain and Cognition In: , Vol. 111, 01.02.2017, p. 51-62.
- "Neuroscience of alcohol for addiction medicine : Neurobiological targets for prevention and intervention in adolescents." Progress in Brain Research. Vol. 223 Elsevier B.V., 2016. p. 215-235 (Progress in Brain Research; Vol. 223).
- "Adolescent Development of Cortical and White Matter Structure in the NCANDA Sample : Role of Sex, Ethnicity, Puberty, and Alcohol Drinking." Cerebral Cortex In: , Vol. 26, No. 10, 01.10.2016, p. 4101-4121.
- "Aerobic fitness linked to cortical brain development in adolescent males : Preliminary findings suggest a possible role of BDNF genotype." Frontiers in Human Neuroscience In: , Vol. 10, No. JUNE2016, 327, 30.06.2016.
- "Harmonizing DTI measurements across scanners to examine the development of white matter microstructure in 803 adolescents of the NCANDA study." NeuroImage In: , Vol. 130, 15.04.2016, p. 194-213.
- "Binge drinking impacts dorsal striatal response during decision making in adolescents." NeuroImage In: , Vol. 129, 01.04.2016, p. 378-388.
- "Commentary : Risk taking, impulsivity, and externalizing problems in adolescent development - Commentary on Crone et al. 2016." Journal of Child Psychology and Psychiatry and Allied Disciplines In: , Vol. 57, No. 3, 01.03.2016, p. 369-370.
- "Lower Working Memory Performance in Overweight and Obese Adolescents Is Mediated by White Matter Microstructure." Journal of the International Neuropsychological Society In: , Vol. 22, No. 3, 28.01.2016, p. 281-292.
- "Cognitive, Emotion Control, and Motor Performance of Adolescents in the NCANDA Study : Contributions From Alcohol Consumption, Age, Sex, Ethnicity, and Family History of Addiction." Neuropsychology In: , 11.01.2016.
- "The national consortium on alcohol and neuro-development in adolescence (NCANDA) : A multisite study of adolescent development and substance use." Journal of Studies on Alcohol and Drugs In: , Vol. 76, No. 6, 01.11.2015, p. 895-908.
- "The effects of age, sex, and hormones on emotional conflict-related brain response during adolescence." Brain and Cognition In: , Vol. 99, 01.10.2015, p. 135-150.
- "Neurobiological Phenotypes of Familial Chronic Pain in Adolescence : A Pilot fMRI Study." Journal of Pain In: , Vol. 16, No. 9, 3104, 01.09.2015, p. 913-925.
- "Developmental sex differences in resting state functional connectivity of amygdala sub-regions." NeuroImage In: , Vol. 115, 05.07.2015, p. 235-244.
- "Atypical parietal lobe activity to subliminal faces in youth with a family history of alcoholism." American Journal of Drug and Alcohol Abuse In: , Vol. 41, No. 2, 01.03.2015, p. 139-145.
- "Family history density of alcoholism relates to left nucleus accumbens volume in adolescent girls." Journal of Studies on Alcohol and Drugs In: , Vol. 76, No. 1, 01.01.2015, p. 47-56.
- "Advances in human neuroconnectivity research : Applications for understanding familial history risk for alcoholism." Alcohol Research: Current Reviews In: , Vol. 37, No. 1, 2015.
- "Reduced cerebellar brain activity during reward processing in adolescent binge drinkers." Developmental Cognitive Neuroscience In: , 19.12.2014.
- "Sex differences in the neural substrates of spatial working memory during adolescence are not mediated by endogenous testosterone." Brain Research In: , Vol. 1593, 17.12.2014, p. 40-54.