Photo of Bill D. Rooney, Ph.D.

Bill D. Rooney Ph.D.

  • (503) 494-1840

    Portland Campus

    • Professor Advanced Imaging Research Center
    • Associate Professor of Behavioral Neuroscience Graduate Program School of Medicine
    • Director Advanced Imaging Research Center
    • Behavioral Neuroscience Graduate Program School of Medicine
Bill Rooney, Ph.D., is the director of the Advanced Imaging Research Center, a professor in behavioral neurosciences at the OHSU School of Medicine, and a scientist-inventor focused on the development and application of quantitative magnetic resonance techniques to characterize tissue structure and function. 
 
In the lab, he’s working to phenotype brain blood vessels using dynamic MRI acquisitions combined with pharmacokinetic modeling—and to apply these techniques to learn how brain blood vessels change in disease processes such as multiple sclerosis, Alzheimer's disease, and brain tumors. Dr. Rooney also investigates cellular metabolism and its relationship to tissue degeneration. Using 31P and 1H magnetic resonance spectroscopic techniques, he investigates the relationship between defects in energy metabolism and tissue loss. 
 
Dr. Rooney joined OHSU in 2005 after working as a scientist and scholar at the University of California San Francisco and Brookhaven National Laboratory.

Areas of interest

  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • MRI
  • Pharmacokinetics
  • Brain

Education

  • Ph.D., Department of Chemistry at the State University of New York at Stony Brook 1990
  • Fellowship:

    • NIH, NRSA fellowship in neuroimaging, Department of Radiology, University of California, San Francisco

Publications

  • "An automated statistical technique for counting distinct multiple sclerosis lesions." American Journal of Neuroradiology In: , Vol. 39, No. 4, 01.04.2018, p. 626-633.
  • "Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy." PloS one  In: , Vol. 13, No. 3, e0194283, 01.03.2018.
  • "MR imaging-based multimodal autoidentification of perivascular spaces (mMAPS) : Automated morphologic segmentation of enlarged perivascular spaces at clinical field strength." Radiology In: , Vol. 286, No. 2, 01.02.2018, p. 632-642.
  • "Cerebral blood volume mapping with ferumoxytol in dynamic susceptibility contrast perfusion MRI : Comparison to standard of care." Journal of Magnetic Resonance Imaging In: , 01.01.2018.
  • "The NAIMS cooperative pilot project : Design, implementation and future directions." Multiple Sclerosis Journal  In: , 01.10.2017.
  • "Volumetric analysis from a harmonized multisite brain MRI study of a single subject with multiple sclerosis." American Journal of Neuroradiology In: , Vol. 38, No. 8, 01.08.2017, p. 1501-1509.
  • "Current and potential imaging applications of ferumoxytol for magnetic resonance imaging." Kidney International In: , Vol. 92, No. 1, 01.07.2017, p. 47-66.
  • "Gradient nonlinearity effects on upper cervical spinal cord area measurement from 3D T-weighted brain MRI acquisitions." Magnetic Resonance in Medicine In: , 2017.
  • "Pseudo-extravasation rate constant of dynamic susceptibility contrast-MRI determined from pharmacokinetic first principles." NMR in Biomedicine In: , 2017.
  • "The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis : a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative." Nature Reviews Neurology  In: , 11.11.2016.
  • "Magnetic resonance imaging of the proximal upper extremity musculature in boys with Duchenne muscular dystrophy." Journal of Neurology In: , 24.10.2016, p. 1-8.
  • "Comparison of cerebral blood flow and structural penumbras in relation to white matter hyperintensities : A multi-modal magnetic resonance imaging study." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 36, No. 9, 01.09.2016, p. 1528-1536.
  • "Relative sensitivities of DCE-MRI pharmacokinetic parameters to arterial input function (AIF) scaling." Journal of Magnetic Resonance In: , Vol. 269, 01.08.2016, p. 104-112.
  • "Toward 20 T magnetic resonance for human brain studies : opportunities for discovery and neuroscience rationale." Magnetic Resonance Materials in Physics, Biology and Medicine In: , 18.05.2016, p. 1-23.
  • "Spatio-temporal patterns of demyelination and remyelination in the cuprizone mouse model." PLoS One  In: , Vol. 11, No. 4, e0152480, 01.04.2016.
  • "Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis." Journal of Neuroimmunology In: , Vol. 291, 15.02.2016, p. 1-10.
  • "Corrections to Comorbidities of epilepsy : Current concepts and future perspectives. [Lancet Neurol, 15, (2015), 106-15]." The Lancet Neurology  In: , Vol. 15, No. 1, 01.01.2016, p. 28.
  • "Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort." Annals of Neurology  In: , 2016.
  • "Duchenne regulatory science consortium meeting on disease progression modeling for duchenne muscular dystrophy." PLoS Currents  In: , Vol. 8, No. MuscularDystrophy, 2016.
  • "Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic : Phase I single group and phase II randomized placebo-controlled studies." Journal of the neurological sciences  In: , Vol. 358, No. 1-2, 15.11.2015, p. 46-52.
  • "Erratum : Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields (Magnetic Resonance in Medicine (2014) 71 (375-387))." Magnetic Resonance in Medicine In: , Vol. 74, No. 5, 01.11.2015, p. 1503.
  • "Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures." NeuroImage: Clinical In: , Vol. 8, 08.06.2015, p. 224-229.
  • "Mapping human brain capillary water lifetime : High-resolution metabolic neuroimaging." NMR in Biomedicine In: , Vol. 28, No. 6, 01.06.2015, p. 607-623.
  • "MRI quantifies neuromuscular disease progression." The Lancet Neurology  In: , 2015.
  • "Loss of pons-to-hypothalamic white matter tracks in brainstem obesity." International Journal of Obesity In: , Vol. 38, No. 12, 11.12.2014, p. 1573-1577.
  • "Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency." Journal of Clinical Endocrinology and Metabolism In: , Vol. 99, No. 10, 01.10.2014, p. E1862-E1869.
  • "Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS." Neurology  In: , Vol. 83, No. 11, 01.09.2014, p. 974-980.
  • "Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields." Magnetic Resonance in Medicine In: , Vol. 71, No. 1, 01.2014, p. 375-387.
  • "Markers of cochlear inflammation using MRI." Journal of Magnetic Resonance Imaging In: , Vol. 39, No. 1, 01.2014, p. 150-161.
  • "Intratumor mapping of intracellular water lifetime : Metabolic images of breast cancer?" NMR in Biomedicine  In: , Vol. 27, No. 7, 2014, p. 760-773.

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