Photo of Ann Hill, Ph.D.

Ann Hill Ph.D.

  • (503) 494-0763
    • Professor of Molecular Microbiology and Immunology School of Medicine

My laboratory investigates T cell immunity to viral infections. Our main interest is in herpesvirus immune evasion genes- how they function, and what effect this has on the immune response to the virus and the virus infective process. We use murine cytomegalovirus (MCMV) as our main model. Cytomegalovirus (CMV) is a ubiquitous infection, infecting approximately 70% of adults in the US. CMV infects in childhood and establishes lifelong infection, usually without symptoms. Immunity to CMV occupies a surprisingly high proportion of the immune system throughout life: around 4% of CD4+ and 10% of CD8+ T cells in chronically infected people are specific for CMV, probably more than for any other virus. This high number of T cells is thought to be maintained by recurrent virus activity, which nevertheless normally remains below the threshold of detection. However, if immunity is compromised, CMV rapidly reactivates and is a main cause of morbidity in most clinically immunocompromized states. It thus appears that the chronic equilibrium between CMV and host involves a lot of activity on both virus and host sides. The long term goal of my lab is to understand this equilibrium and its consequences for the host.

Publications

  • "Blocking virus replication during acute murine cytomegalovirus infection paradoxically prolongs antigen presentation and increases the CD8 T cell response by preventing type I IFN-dependent depletion of dendritic cells." Journal of Immunology In: , Vol. 198, No. 1, 01.01.2017, p. 383-393.
  • "A Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimera Vaccines in Cytomegalovirus-Seronegative Men." Journal of Infectious Diseases  In: , Vol. 214, No. 9, 01.11.2016, p. 1341-1348.
  • "Intratumoral Infection with Murine Cytomegalovirus Synergizes with PD-L1 Blockade to Clear Melanoma Lesions and Induce Long-term Immunity." Molecular Therapy In: , Vol. 24, No. 8, 01.08.2016, p. 1444-1455.
  • "Strength in Numbers : Visualizing CTL-Mediated Killing In Vivo." Immunity In: , Vol. 44, No. 2, 16.02.2016, p. 207-208.
  • "Cytokine-mediated activation of NK cells during viral infection." Journal of Virology In: , Vol. 89, No. 15, 2015, p. 7922-7931.
  • "Cytomegalovirus-based cancer vaccines expressing TRP2 induce rejection of melanoma in mice." Biochemical and Biophysical Research Communications In: , Vol. 437, No. 2, 26.07.2013, p. 287-291.
  • "Competition for antigen at the level of the APC is a major determinant of immunodominance during memory inflation in murine cytomegalovirus infection." Journal of Immunology In: , Vol. 190, No. 7, 01.04.2013, p. 3410-3416.
  • "CMV and Immunosenescence : From basics to clinics." Immunity and Ageing  In: , Vol. 9, 23, 31.10.2012.
  • "Chronic viral infections and immunosenescence, with a focus on CMV." Open Longevity Science  In: , Vol. 6, 2012, p. 33-38.
  • "Report from the second cytomegalovirus and immunosenescence workshop." Immunity and Ageing  In: , Vol. 8, 10, 28.10.2011.
  • "Sustained CD8+ T cell memory inflation after infection with a single-cycle Cytomegalovirus." PLoS Pathogens In: , Vol. 7, No. 10, e1002295, 10.2011.
  • "When the Going Gets Tough, Memory T Cells Check Out." Immunity  In: , Vol. 35, No. 2, 26.08.2011, p. 158-160.
  • "Comparing the kinetics of NK cells, CD4, and CD8 T cells in murine cytomegalovirus infection." Journal of Immunology In: , Vol. 187, No. 3, 01.08.2011, p. 1385-1392.
  • "Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells." PLoS One In: , Vol. 5, No. 3, e9681, 12.03.2010.
  • "Investigation of the impact of the common animal facility contaminant murine norovirus on experimental murine cytomegalovirus infection." Virology In: , Vol. 392, No. 2, 30.09.2009, p. 153-161.
  • "CD4+ T cell help has an epitope-dependent impact on CD8 + T cell memory inflation during murine cytomegalovirus infection." Journal of Immunology In: , Vol. 183, No. 6, 15.09.2009, p. 3932-3941.
  • "Ly49P recognition of cytomegalovirus-infected cells expressing H2-D k and CMV-encoded m04 correlates with the NK cell antiviral response." Journal of Experimental Medicine In: , Vol. 206, No. 3, 16.03.2009, p. 515-523.
  • "Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells." Immunity In: , Vol. 29, No. 4, 17.10.2008, p. 650-659.
  • "The dynamics of mouse cytomegalovirus-specific CD4 T cell responses during acute and latent infection." Journal of Immunology  In: , Vol. 181, No. 2, 15.07.2008, p. 1128-1134.
  • "MHC class I immune evasion in MCMV infection." Medical Microbiology and Immunology In: , Vol. 197, No. 2, 06.2008, p. 191-204.
  • "Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination." Journal of Virology In: , Vol. 82, No. 12, 06.2008, p. 5781-5796.
  • "T cell acquisition of APC membrane can impact interpretation of adoptive transfer experiments using CD45 congenic mouse strains." Journal of Immunological Methods In: , Vol. 330, No. 1-2, 31.01.2008, p. 137-145.
  • "The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the murine cytomegalovirus immunoevasin m152/gp40." Journal of Virology In: , Vol. 81, No. 22, 11.2007, p. 12564-12571.
  • "DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (Helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge." Journal of Virology In: , Vol. 81, No. 14, 07.2007, p. 7766-7775.
  • "Viral interference with antigen presentation does not alter acute or chronic CD8 T cell immunodominance in murine cytomegalovirus infection." Journal of Immunology In: , Vol. 178, No. 11, 01.06.2007, p. 7235-7241.
  • "Coordinated function of murine cytomegalovirus genes completely inhibits CTL lysis." Journal of Immunology In: , Vol. 177, No. 5, 01.09.2006, p. 3225-3234.
  • "Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection." Journal of Immunology In: , Vol. 177, No. 1, 01.07.2006, p. 450-458.
  • "Cellular and molecular requirements for association of the murine cytomegalovirus protein m4/gp34 with major histocompatibility complex class I molecules." Journal of Virology In: , Vol. 80, No. 12, 06.2006, p. 6048-6055.
  • "Immunodominance in the T-Cell Response to Herpesviruses."  Immunodominance: The Choice of the Immune System. Wiley-VCH Verlag GmbH & Co. KGaA, 2006. p. 255-283.
  • "Murine cytomegalovirus interference with antigen presentation contributes to the inability of CD8 T cells to control virus in the salivary gland." Journal of Virology In: , Vol. 80, No. 8, 04.2006, p. 4200-4202.

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