Photo of Allison Fryer, Ph.D.

Allison Fryer Ph.D.

    • Professor of Medicine, Division of Pulmonary and Critical Care Medicine School of Medicine
    • Associate Dean, Graduate Studies Office of the Dean School of Medicine
    • Neuroscience Graduate Program School of Medicine

I have shown that airway hyperreactivity, that is similar to asthma, is accompanied by recruitment of eosinophil inflammatory cells to airway nerves. These eosinophils are activated and release a preformed protein, eosinophil major basic protein, which binds to and blocks M2 muscarinic receptors on nerves.  M2 blockade increases neurotransmitter release and increases bronchoconstriction, similar to asthma. My lab is examining what mechanisms underlie recruitment and activation of eosinophils at the autonomic nerves in the lungs. We are also working to understand how exposure to viral infection, organophosphate pesticides, ozone, or allergens all induce loss of M2 receptor function in the nerves, and the role of eosinophils in the resulting airway hyperreactivity.Collaborations include:David Jacoby MD (Division of Pulmonary and Critical Care Medicine). Viral infections and biochemical interactions of inflammatory mediators with M2 muscarinic receptors. Current Graduate Students: Kalmia Smith Buels (joined 2006) and Sarah Vogel (joined 2010). Recent Graduates: Kirsten Blensly (PhD 2010) Postdoc NIEHS, NC. Norah Verbout (PhD 2008) postdoc at Harvard University, MA. Mehdi Hazari (PhD 2005) Faculty at EPA.

  • Fellowship:

    • Post-Doctoral Fellowship Univ. of California 1988Post-Doctoral Fellowship, Univ. of Maryland, 1989

Publications

  • "RIFM fragrance ingredient safety assessment, Isobornyl 2-methylpropionate, CAS Registry Number 85586-67-0." Food and Chemical Toxicology In: , 22.11.2016.
  • "RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S147-S156.
  • "RIFM fragrance ingredient safety assessment, Isopropylphenylbutanal, CAS Registry Number 125109-85-5." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S230-S236.
  • "RIFM fragrance ingredient safety assessment, 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one, CAS Registry Number 56973-87-6." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S224-S229.
  • "RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S136-S146.
  • "RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S1-S10.
  • "RIFM fragrance ingredient safety assessment, 2-Hydroxy-α,α,4-trimethylcyclohexanemethanol, CAS Registry Number 42822-86-6." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S209-S215.
  • "RIFM fragrance ingredient safety assessment, α-Methylbenzyl acetate, CAS Registry Number 93-92-5." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S57-S68.
  • "RIFM fragrance ingredient safety assessment, 2-methylundecanol, CAS Registry Number 10522-26-6." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S119-S128.
  • "RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S101-S109.
  • "RIFM fragrance ingredient safety assessment, linalyl benzoate, CAS Registry Number 126-64-7." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S180-S191.
  • "RIFM fragrance ingredient safety assessment, isobornyl propionate, CAS Registry Number 2756-56-1." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S216-S223.
  • "RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS Registry Number 78-37-5." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S110-S118.
  • "RIFM fragrance ingredient safety assessment, Isopulegol, CAS Registry Number 89-79-2." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S129-S135.
  • "RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1,6-nonadien-3-ol, CAS Registry Number 10339-55-6." Food and Chemical Toxicology In: , Vol. 97, 01.11.2016, p. S168-S179.
  • "RIFM fragrance ingredient safety assessment, elemol, CAS Registry Number 639-99-6." Food and Chemical Toxicology In: , 01.11.2016.
  • "RIFM fragrance ingredient safety assessment, β-Guaiene, CAS Registry Number 88-84-6." Food and Chemical Toxicology In: , 19.10.2016.
  • "RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, 6-acetyl-1,1,2,4,4,7-hexamethyltetraline, CAS Registry Number 21145-77-7." Food and Chemical Toxicology In: , 19.10.2016.
  • "RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9." Food and Chemical Toxicology In: , 27.09.2016.
  • "RIFM fragrance ingredient safety assessment, 5-Ethylidenebicyclo[2.2.1]hept-2-yl propionate, CAS Registry Number 73347-77-0." Food and Chemical Toxicology In: , 14.09.2016.
  • "Human and mouse eosinophils have antiviral activity against parainfluenza virus." American Journal of Respiratory Cell and Molecular Biology In: , Vol. 55, No. 3, 01.09.2016, p. 387-394.
  • "RIFM fragrance ingredient safety assessment, 2-ethyl-1-butanol, CAS Registry Number 97-95-0." Food and Chemical Toxicology In: , 26.08.2016.
  • "RIFM fragrance ingredient safety assessment, ethylene brassylate, CAS Registry Number 105-95-3." Food and Chemical Toxicology In: , 24.08.2016.
  • "RIFM fragrance ingredient safety assessment, 1,3,3-trimethyl-2-norbornanyl acetate, CAS registry number 13851-11-1." Food and Chemical Toxicology In: , 17.08.2016.
  • "RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7." Food and Chemical Toxicology In: , 28.06.2016.
  • "RIFM fragrance ingredient safety assessment, p-Isopropylbenzyl acetate, CAS Registry Number 59230-57-8." Food and Chemical Toxicology In: , 11.03.2016.
  • "RIFM fragrance ingredient safety assessment, 4-methylbenzyl acetate, CAS Registry Number 2216-45-7." Food and Chemical Toxicology In: , 11.03.2016.
  • "RIFM fragrance ingredient safety assessment, benzyl isobutyrate, CAS Registry Number 103-28-6." Food and Chemical Toxicology In: , 11.03.2016.
  • "RIFM fragrance ingredient safety assessment, isoeugenol, CAS Registry Number 97-54-1." Food and Chemical Toxicology In: , 11.11.2015.
  • "RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0." Food and Chemical Toxicology In: , 11.11.2015.

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