Photo of Allison Fryer, Ph.D.

Allison Fryer Ph.D.

    • Professor of Medicine, Division of Pulmonary and Critical Care Medicine School of Medicine
    • Associate Dean, Graduate Studies Office of the Dean School of Medicine
    • Neuroscience Graduate Program School of Medicine

I have shown that airway hyperreactivity, that is similar to asthma, is accompanied by recruitment of eosinophil inflammatory cells to airway nerves. These eosinophils are activated and release a preformed protein, eosinophil major basic protein, which binds to and blocks M2 muscarinic receptors on nerves.  M2 blockade increases neurotransmitter release and increases bronchoconstriction, similar to asthma. My lab is examining what mechanisms underlie recruitment and activation of eosinophils at the autonomic nerves in the lungs. We are also working to understand how exposure to viral infection, organophosphate pesticides, ozone, or allergens all induce loss of M2 receptor function in the nerves, and the role of eosinophils in the resulting airway hyperreactivity.Collaborations include:David Jacoby MD (Division of Pulmonary and Critical Care Medicine). Viral infections and biochemical interactions of inflammatory mediators with M2 muscarinic receptors. Current Graduate Students: Kalmia Smith Buels (joined 2006) and Sarah Vogel (joined 2010). Recent Graduates: Kirsten Blensly (PhD 2010) Postdoc NIEHS, NC. Norah Verbout (PhD 2008) postdoc at Harvard University, MA. Mehdi Hazari (PhD 2005) Faculty at EPA.

  • Fellowship:

    • Post-Doctoral Fellowship Univ. of California 1988Post-Doctoral Fellowship, Univ. of Maryland, 1989

Publications

  • "In Memory and Celebration : Dr. James J. Lee." Clinical and Experimental Allergy In: , Vol. 47, No. 7, 01.07.2017, p. 980-981.
  • "Newly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs." American Journal of Physiology - Lung Cellular and Molecular Physiology In: , Vol. 312, No. 6, 05.06.2017, p. L969-L982.
  • "RIFM fragrance ingredient safety assessment, isodecyl alcohol, CAS registry number 25339-17-7." Food and Chemical Toxicology In: , 19.05.2017.
  • "RIFM fragrance ingredient safety assessment, 2-methyl-4(2,2,3-trimethyl-3-cyclopentenyl)butanol, CAS Registry Number 72089-08-8." Food and Chemical Toxicology In: , 08.05.2017.
  • "RIFM fragrance ingredient safety assessment, benzoic acid, 2-[(1-oxopropyl)amino]-, methyl ester, CAS Registry Number 25628-84-6." Food and Chemical Toxicology In: , 03.05.2017.
  • "RIFM Fragrance Ingredient Safety Assessment, Butyl anthranilate, CAS Registry Number 7756-96-9." Food and Chemical Toxicology In: , 02.05.2017.
  • "RIFM fragrance ingredient safety assessment, 2-tert-butylcyclohexanol, CAS Registry Number 13491-79-7." Food and Chemical Toxicology In: , 02.05.2017.
  • "RIFM fragrance ingredient safety assessment, methyl anthranilate, CAS Registry Number 134-20-3." Food and Chemical Toxicology In: , 01.05.2017.
  • "RIFM fragrance ingredient safety assessment, methyl N-acetylanthranilate, CAS Registry Number 2719-08-6." Food and Chemical Toxicology In: , 25.04.2017.
  • "RIFM fragrance ingredient safety assessment, dihydro-α-terpineol, CAS Registry Number 498-81-7." Food and Chemical Toxicology In: , 17.04.2017.
  • "RIFM fragrance ingredient safety assessment, Isoamyl butyrate, CAS Registry Number 106-27-4." Food and Chemical Toxicology In: , 03.04.2017.
  • "RIFM fragrance ingredient safety assessment, .α.-methylcyclohexylmethyl acetate, CAS Registry Number 13487-27-9." Food and Chemical Toxicology In: , 03.04.2017.
  • "RIFM fragrance ingredient safety assessment, 3-methylbutyl valerate, CAS Registry Number 2050-09-1." Food and Chemical Toxicology In: , 17.03.2017.
  • "RIFM fragrance ingredient safety assessment, isoamyl acetate, CAS Registry Number 123-92-2." Food and Chemical Toxicology In: , 27.02.2017.
  • "RIFM fragrance ingredient safety assessment, 3-methylbutyl 2-methylpropanoate, CAS Registry Number 2050-01-3." Food and Chemical Toxicology In: , 23.02.2017.
  • "RIFM fragrance ingredient safety assessment, isoamyl hexanoate, CAS Registry Number 2198-61-0." Food and Chemical Toxicology In: , 23.02.2017.
  • "RIFM fragrance ingredient safety assessment, cuminyl nitrile, CAS Registry Number 13816-33-6." Food and Chemical Toxicology In: , 23.02.2017.
  • "RIFM fragrance ingredient safety assessment, 5-Acetyl-3-isopropyl-1,1,2,6-tetramethylindane, CAS Registry Number 68140-48-7." Food and Chemical Toxicology In: , 16.02.2017.
  • "RIFM fragrance ingredient safety assessment, Isoamyl octanoate, CAS Registry Number 2035-99-6." Food and Chemical Toxicology In: , 19.01.2017.
  • "RIFM fragrance ingredient safety assessment, isoamyl formate, CAS Registry Number 110-45-2." Food and Chemical Toxicology In: , 18.01.2017.
  • "RIFM fragrance ingredient safety assessment, isoamyl propionate, CAS Registry Number 105-68-0." Food and Chemical Toxicology In: , 18.01.2017.
  • "RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1-octanyl acetate, CAS Registry Number 20780-49-8." Food and Chemical Toxicology In: , 17.01.2017.
  • "RIFM fragrance ingredient safety assessment, 1-cyclohexylethyl butyrate, CAS Registry Number 63449-88-7." Food and Chemical Toxicology In: , 16.01.2017.
  • "RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5." Food and Chemical Toxicology In: , 16.01.2017.
  • "RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, 2-Methylbutanol, CAS Registry Number 137-32-6." Food and Chemical Toxicology In: , 13.01.2017.
  • "RIFM fragrance ingredient safety assessment, l-Cyclocitronellene formate, CAS Registry Number 25225-08-5." Food and Chemical Toxicology In: , 10.01.2017.
  • "RIFM fragrance ingredient safety assessment, isononyl propionate, CAS Registry Number 65155-45-5." Food and Chemical Toxicology In: , 10.01.2017.
  • "RIFM fragrance ingredient safety assessment, isotridecyl acetate, CAS registry number 69103-23-7." Food and Chemical Toxicology In: , 09.01.2017.
  • "RIFM fragrance ingredient safety assessment, benzenepropanenitrile, 4-ethyl-.α.,.α.-dimethyl, CAS Registry Number 134123-93-6." Food and Chemical Toxicology In: , 2017.
  • "RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5." Food and Chemical Toxicology In: , 02.12.2016.

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