Photo of Alfred J. Lewy, M.D., Ph.D.

Alfred J. Lewy M.D., Ph.D.

    • Professor of Psychiatry School of Medicine
    • Richard H. Phillips Professor of Adult Psychiatry Psychiatry School of Medicine

Dr. Lewy, along with Robert Sack, M.D., have been investigating the use of melatonin as a treatment for circadian phase disorders, including those found in shift workers and blind people. "I take care of two types of patients, those who need light or melatonin treatment and those who need psychotherapy and other medications for psychiatric and sleep disorders," he said. His specialty is in body clock disorders, sleep disorders and depression and anxiety. He has been involved in clinical trials regarding winter depression and the treatment of totally blind people who have drifting circadian rhythms. Dr. Lewy is also investigating how a daily dose of melatonin can synchronize the sleep cycles of totally blind people who have no light perception.

  • Residency:

    • Psychiatry-Mt. Zion Hospital, San Francisco
  • Fellowship:

    • Psychiatry-National Institute of Mental Health
  • Certifications:

    • Psychiatry, 1981

Publications

  • "Behavioral and biochemical effects of FK 33-824, a parenterally and orally active enkephalin analogue."  Endorphins in Mental Health Research. Palgrave Macmillan, 2016. p. 279-292.
  • "Circadian rhythms and mood disorders : A guide for the perplexed." Journal of Clinical Psychiatry In: , Vol. 76, No. 5, 01.05.2015, p. e662-e664.
  • "The role of circadian rhythms, light and melatonin in SAD and nonseasonal affective and anxiety disorders." Current Psychiatry Reviews In: , Vol. 10, No. 3, 01.01.2014, p. 214-222.
  • "Non-24-hour disorder in blind individuals revisited : Variability and the influence of environmental time cues." Sleep In: , Vol. 36, No. 7, 01.07.2013, p. 1091-1100.
  • "Rest-activity cycle and melatonin rhythm in blind free-runners have similar periods." Journal of Biological Rhythms In: , Vol. 25, No. 5, 10.2010, p. 381-384.
  • "Clinical implications of the melatonin phase response curve." Journal of Clinical Endocrinology and Metabolism  In: , Vol. 95, No. 7, 07.2010, p. 3158-3160.
  • "Depressive disorders may more commonly be related to circadian phase delays rather than advances : Time will tell." Sleep Medicine In: , Vol. 11, No. 2, 02.2010, p. 117-118.
  • "To sleep, perchance to reset your body clock." Psychiatric Times In: , Vol. 27, No. 1, 01.2010, p. 17-22.
  • "The neurohormone melatonin as a marker, medicament, and mediator."  Hormones, Brain and Behavior Online. Elsevier Inc., 2010. p. 2505-2528.
  • "Circadian Function and Therapeutic Potential of Melatonin in Humans."  Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 893-900.
  • "Circadian misalignment in mood disturbances." Current Psychiatry Reports In: , Vol. 11, No. 6, 12.2009, p. 459-465.
  • "Circadian misalignment in major depressive disorder." Psychiatry Research  In: , Vol. 168, No. 3, 15.08.2009, p. 259-261.
  • "Review of disrupted sleep patterns in Smith-Magenis syndrome and normal melatonin secretion in a patient with an atypical interstitial 17p11.2 deletion." American Journal of Medical Genetics, Part A  In: , Vol. 149, No. 7, 07.2009, p. 1382-1391.
  • "Winter Depression : Integrating Mood, Circadian Rhythms, and the Sleep/Wake and Light/Dark Cycles into a Bio-Psycho-Social-Environmental Model." Sleep Medicine Clinics  In: , Vol. 4, No. 2, 06.2009, p. 285-299.
  • "Phase angle of entrainment in morning- and evening-types under naturalistic conditions." Chronobiology International In: , Vol. 26, No. 3, 04.2009, p. 474-493.
  • "Measuring melatonin in humans." Journal of Clinical Sleep Medicine In: , Vol. 4, No. 1, 15.02.2008, p. 66-69.
  • "Current understanding and future implications of the circadian uses of melatonin, a neurohormone discovered by Aaron B. Lerner." The Journal of investigative dermatology In: , Vol. 127, No. 9, 09.2007, p. 2082-2085.
  • "Plasminogen activator inhibitor-1 has a circadian rhythm in blind individuals [3]." Thrombosis and Haemostasis In: , Vol. 98, No. 2, 08.2007, p. 479-481.
  • "Missed antenatal depression among high risk women : A secondary analysis." Archives of Women's Mental Health In: , Vol. 10, No. 3, 06.2007, p. 121-123.
  • "The phase shift hypothesis for the circadian component of winter depression." Dialogues in Clinical Neuroscience In: , Vol. 9, No. 3, 2007, p. 291-300.
  • "Melatonin and human chronobiology." Cold Spring Harbor Symposia on Quantitative Biology In: , Vol. 72, 2007, p. 623-636.
  • "The circadian basis of winter depression." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 103, No. 19, 09.05.2006, p. 7414-7419.
  • "Circadian uses of melatonin in humans." Chronobiology International  In: , Vol. 23, No. 1-2, 2006, p. 403-412.
  • "Sleep and circadian rhythms in the blind."  Neuroendocrine Correlates of Sleep/Wakefulness. Springer US, 2006. p. 311-323.
  • "Rutger Wever : an appreciation." Journal of biological rhythms.  In: , Vol. 20, No. 6, 12.2005, p. 554-555.
  • "Melatonin entrains free-running blind people according to a physiological dose-response curve." Chronobiology International In: , Vol. 22, No. 6, 11.2005, p. 1093-1106.
  • "Relative coordination to unknown "weak zeitgebers" in free-running blind individuals." Journal of Biological Rhythms In: , Vol. 20, No. 2, 04.2005, p. 159-167.
  • "Eventual Entrainment of the Human Circadian Pacemaker by Melatonin Is Independent of the Circadian Phase of Treatment Initiation : Clinical Implications." Journal of Biological Rhythms In: , Vol. 19, No. 1, 02.2004, p. 68-75.
  • "Zeitgeber hierarchy in humans : Resetting the circadian phase positions of blind people using melatonin." Chronobiology International In: , Vol. 20, No. 5, 2003, p. 837-852.
  • "Clinical applications of melatonin in circadian disorders." Dialogues in Clinical Neuroscience In: , Vol. 5, No. 4, 2003, p. 399-413.

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