Photo of Alejandro Lomniczi

Alejandro Lomniczi

  • (503) 346-5495
    • Research Assistant Professor Oregon National Primate Research Center
    • Affiliate Scientist, Primate Genetics Oregon National Primate Research Center

Dr Lomniczi is a Research Assistant Professor in the Division of Neuroscience and an Affiliate Scientist in the Primate Genetics Program at ONPRC-OHSU. He received his PhD degree from the University of Buenos Aires, Argentina in 2001. In 2002 he moved to Dr. Sergio Ojeda’s Lab to perform his postdoctoral training in Neuroendocrinology and Reproductive Biology at the Division of Neuroscience, ONPRC-OHSU. Dr. Lomniczi has mentored several students and postdoctoral fellows. He is a member of the editorial board of Neuroendocrinology and has been invited to give numerous lectures at national and international meetings. In addition, he has participated in diverse Neuroendocrine and Epigenetic related courses. His work has been cited more than 1500 times.

The Lomniczi Laboratory specializes in neuroendocrinology and cell biology, with emphasis in genetic and epigenetic mechanisms that control physiological responses. The primary focus of the Lab is to unveil how epigenetic landscapes of neurons and glial cells change in response to external conditions such as diet manipulation, stress, changes in circadian patterns, or exposure to endocrine disruptors that modulate cellular function.

Recent studies from the Lomniczi Lab have revealed that an epigenetic mechanism of transcriptional repression operating in the hypothalamus plays a vital role in timing female puberty. Dr. Lomniczi’ s results strongly suggest that the epigenetic control of puberty involves lifting of a transcriptional repressive tone exerted by the Polycomb group (PcG) of transcriptional silencers, with the simultaneous recruitment of a group of transcriptional activators from the Trithorax family. This dynamic Yin-Yang of repression vs activation is imposed on a regulatory system (epitomized by the Kiss1 gene) directly involved in the stimulatory control of GnRH secretion ultimately controlling reproductive function.

Currently, the Lomniczi Laboratory is exploring the role of epigenetics in conveying nutritional status information to the cellular networks involved in the hypothalamic control of GnRH secretion. They use a combination of multiple techniques including RNA-seq, ChIP-seq genome-wide DNA methylation analysis, and a battery of histological and physiological methods.

 

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Areas of interest

  • Reproductive Neuroendocrinology
  • Genetic and Epigenetic Programming
  • Brain Development
  • Puberty and Adolescence

Education

  • Ph.D., University of Buenos Aires Argentina 2002
  • B.A., University of Buenos Aires Argentina 1997

Memberships and associations

  • Editorial Board of Neuroendocrinology
  • Endocrine society, member
  • Society of Neuroscience, member

Publications

Selected publications

  • Lomniczi A, Ojeda SR. The Emerging Role of Epigenetics in the Regulation of Female Puberty. Endocr Dev. 2016;29:1-16. doi: 10.1159/000438840. Epub 2015 Dec 17. Review. PubMed PMID: 26680569; PubMed Central PMCID: PMC4955615.

  • Lomniczi A, Wright H, Castellano JM, Matagne V, Toro CA, Ramaswamy S, Plant TM, Ojeda SR. Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression. Nat Commun. 2015 Dec 16;6:10195. doi: 10.1038/ncomms10195. PubMed PMID: 26671628; PubMed Central PMCID: PMC4703871.

  • Lomniczi A, Wright H, Ojeda SR. Epigenetic regulation of female puberty. Front Neuroendocrinol. 2015 Jan;36:90-107. doi: 10.1016/j.yfrne.2014.08.003. Epub 2014 Aug 27. Review. PubMed PMID: 25171849.

  • Topaloglu AK, Lomniczi A, Kretzschmar D, Dissen GA, Kotan LD, McArdle CA, Koc AF, Hamel BC, Guclu M, Papatya ED, Eren E, Mengen E, Gurbuz F, Cook M, Castellano JM, Kekil MB, Mungan NO, Yuksel B, Ojeda SR. Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome. J Clin Endocrinol Metab. 2014 Oct;99(10):E2067-75. doi: 10.1210/jc.2014-1836. Epub 2014 Jul 17. PubMed PMID: 25033069; PubMed Central PMCID: PMC5393493.

  • Castellano JM, Wright H, Ojeda SR, Lomniczi A. An alternative transcription start site yields estrogen-unresponsive Kiss1 mRNA transcripts in the hypothalamus of prepubertal female rats. Neuroendocrinology. 2014;99(2):94-107. doi: 10.1159/000362280. Epub 2014 Mar 28. PubMed PMID: 24686008; PubMed Central PMCID: PMC4111975.

  • Ojeda SR, Lomniczi A. Puberty in 2013: Unravelling the mystery of puberty. Nat Rev Endocrinol. 2014 Feb;10(2):67-9. doi: 10.1038/nrendo.2013.233. Epub 2013 Nov 26. Review. PubMed PMID: 24275741.

  • Lomniczi A, Loche A, Castellano JM, Ronnekleiv OK, Bosch M, Kaidar G, Knoll JG, Wright H, Pfeifer GP, Ojeda SR. Epigenetic control of female puberty. Nat Neurosci. 2013 Mar;16(3):281-9. doi: 10.1038/nn.3319. Epub 2013 Jan 27. PubMed PMID: 23354331; PubMed Central PMCID: PMC3581714.

  • Lomniczi A, Garcia-Rudaz C, Ramakrishnan R, Wilmot B, Khouangsathiene S, Ferguson B, Dissen GA, Ojeda SR. A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates. Endocrinology. 2012 Jan;153(1):339-49. doi: 10.1210/en.2011-1540. Epub 2011 Nov 29. PubMed PMID: 22128021; PubMed Central PMCID: PMC3249686.

Publications

  • "The systemic and gonadal toxicity of 3-methylcholanthrene is prevented by daily administration of α-naphthoflavone." Toxicology  In: , Vol. 353-354, 15.04.2016, p. 58-69.
  • "The emerging role of epigenetics in the regulation of female puberty." Endocrine Development In: , Vol. 29, 2016, p. 1-16.
  • "Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility : An update." Reproduction in Domestic Animals  In: , 2016.
  • "Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression." Nature Communications In: , Vol. 6, 10195, 16.12.2015.
  • "Epigenetic regulation of female puberty." Frontiers in Neuroendocrinology In: , Vol. 36, 01.01.2015, p. 90-107.
  • "Gene networks, epigenetics and the control of female puberty." Research and Perspectives in Endocrine Interactions In: , Vol. 13, 2015, p. 97-119.
  • "Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome." Journal of Clinical Endocrinology and Metabolism In: , Vol. 99, No. 10, 01.10.2014, p. E2067-E2075.
  • "Puberty in 2013 : Unravelling the mystery of puberty." Nature Reviews Endocrinology  In: , Vol. 10, No. 2, 02.2014, p. 67-69.
  • "Loss of NTRK2/KISS1R signaling in oocytes causes premature Ovarian failure." Endocrinology In: , Vol. 155, No. 8, 2014, p. 3098-3111.
  • "An alternative transcription start site yields estrogen-unresponsive kiss1 mRNA transcripts in the hypothalamus of prepubertal female rats." Neuroendocrinology  In: , Vol. 99, No. 2, 2014, p. 94-107.
  • "A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates." Hormones and Behavior In: , Vol. 64, No. 2, 07.2013, p. 175-186.
  • "Epigenetic control of female puberty." Nature Neuroscience In: , Vol. 16, No. 3, 03.2013, p. 281-289.
  • "Applying Gene Silencing Technology to Contraception." Reproduction in Domestic Animals In: , Vol. 47, No. SUPPL. 6, 12.2012, p. 381-386.
  • "Targeted gene silencing to induce permanent sterility." Reproduction in Domestic Animals In: , Vol. 47, No. SUPPL.4, 08.2012, p. 228-232.
  • "Transcription of the human EAP1 gene is regulated by upstream components of a puberty-controlling Tumor Suppressor Gene network." Molecular and Cellular Endocrinology  In: , Vol. 351, No. 2, 04.04.2012, p. 184-198.
  • "Hypothalamic EAP1 (Enhanced at Puberty 1) is required for menstrual cyclicity in nonhuman primates." Endocrinology In: , Vol. 153, No. 1, 01.2012, p. 350-361.
  • "A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates." Endocrinology In: , Vol. 153, No. 1, 01.2012, p. 339-349.
  • "Transcriptional regulation of the human KiSS1 gene." Molecular and Cellular Endocrinology  In: , Vol. 342, No. 1-2, 06.08.2011, p. 8-19.
  • "A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2." Molecular and Cellular Biology In: , Vol. 31, No. 11, 06.2011, p. 2287-2298.
  • "The transcriptional control of female puberty." Brain Research In: , Vol. 1364, 10.12.2010, p. 164-174.
  • "Contribution of glial-neuronal interactions to the neuroendocrine control of female puberty." European Journal of Neuroscience  In: , Vol. 32, No. 12, 12.2010, p. 2003-2010.
  • "Gene networks and the neuroendocrine regulation of puberty." Molecular and Cellular Endocrinology In: , Vol. 324, No. 1-2, 08.2010, p. 3-11.
  • "Neuroendocrinology of puberty."  Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 367-375.
  • "New concepts on the control of the onset of puberty."   Pediatric Neuroendocrinology. Vol. 17 S. Karger AG, 2009. p. 44-51.
  • "New concepts on the control of the onset of puberty." Endocrine Development  In: , Vol. 17, 11.2009, p. 44-51.
  • "In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles." Methods In: , Vol. 49, No. 1, 09.2009, p. 70-77.
  • "A role for glial cells of the neuroendocrine brain in the central control of female sexual development."  Astrocytes in (Patho)Physiology of the Nervous System. Springer US, 2009. p. 487-511.
  • "Glial-gonadotrophin hormone (GnRH) neurone interactions in the median eminence and the control of gnrh secretion." Journal of Neuroendocrinology In: , Vol. 20, No. 6, 06.2008, p. 732-742.
  • "Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway." Endocrinology  In: , Vol. 149, No. 3, 03.2008, p. 1358-1365.
  • "A contactin-receptor-like protein tyrosine phosphatase β complex mediates adhesive communication between astroglial cells and gonadotrophin-releasing hormone neurones." Journal of Neuroendocrinology In: , Vol. 19, No. 11, 11.2007, p. 847-858.

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