Division Faculty


Faculty Profile:

Jeffrey A. Gold, MD

Associate Professor of Medicine
Division of Pulmonary and Critical Care Medicine, OHSU
Email: goldje@ohsu.edu


Degrees:
  • BS/BA – SUNY Binghamton, 1991
  • MD- New York University School of Medicine,. 1995


Residency:

  • Internal Medicine- Columbia Presbyterian Medical Center, N,Y NY,
    1995-1998


Fellowship:

  • Pulmonary and Critical Care Medicine- NYU Medical Center, NY,NY.
    1998-2001


Research Interest:

  • Innate immunity in septic shock
  • Treatment of Delerium tremens and severe alcohol withdrawal


Clinical Interest:

  • Septic Shock
  • Alcohol withdrawal
  • Acute lung injury

Representative Publications:

  • Gold JA , Cullinane S, Chen J, Seo S, Oz, MC, Oliver JA, Landry DW. Vasopressin in the treatment of Milrinone-induced hypotension in severe heart failure. Am J Card 2000; 85: 506-8.

  • Gold JA, Cullinane S, Chen J, Oz, MC, Oliver JA, Landry DW. Vasopressin as an alternative to norepinephrine in the treatment of Milrinone induced hypotension. Crit Care Med 2000; 28:249-52.

  • Gold JA , Parsey M, Yee H, Tse D, Weiden M. Role of CD40 in sepsis induced acute lung injury. Infection and Immunity 2003; 71:3521-8.

  • Gold JA, Hoshino Y, Tanaka N, Rom WN, Raju B, Condos R, Weiden MD. SP-A modulates the inflammatory response in macrophages during tuberculosis. Infection and Immunity 2004; 72: 645-50.

  • Gold JA, Hoshino Y, Jones MB, Hoshino S, Nolan A, Weiden MD. Exogenous Type I and Type II Interferon rescues human macrophages from B.anthracis cell death. Infection and Immunity 2004; 72:1291-7.

  • Raju B, Hoshino Y, Kuwabara K, Canova A, Gold JA, Condos R, Pine RI, Rom WN, Weiden M. Aerosolized Interferon-gamma Induces IP-10 but not iNOS Gene Expression in Lung Cells During Tuberculosis. Infection and Immunity 2004; 72:1275-183.

  • Hoshino Y, Tse DB, Rochford , Prabhakar S, Hoshino S, Kuwabara K, Ching E, Raju B, Gold JA, Borkowsky W, Rom WN, Weiden MD, Pine R. Mycobacterium tuberculosis infection of macrophages in vivo and in vitro induces CXCR4 (CD184) and Chemokine Expression leading to preferential X4 HIV-1 infection in coinfected macrophages. J. Immunology 2004; 172:6251-8.

  • Nolan A, Weiden M, Thurston G, Gold JA. Vascular Endothelial Growth Factor Blockade Reduces Serum Cytokines in a Murine Model of Polymicrobial Sepsis. Inflammation 2004, 28:271-5.

  • Nolan A, Weiden MD, Hoshino Y, Gold JA. CD40 but not CD154 knockout mice have reduced inflammatory response in polymicrobial sepsis: a potential role for E.coli HSP70 in CD40 mediated inflammation in vivo. SHOCK 2004 22:538-542.


Biosketch:

Dr. Gold’s main research focus is investigating the role of costimulatory molecules in the innate immune response during polymicrobial sepsis. The lab has previously described an essential role for the costimualtory receptor, CD40, in controlling inflammation in murine polymicrobial sepsis. Currently, the lab will be focusing on the effect of simultaneous inhibition of CD40 and CD80/86 in murine polymicrobial sepsis. This will be done in concert with human trials characterizing the expression profiles of costimualtory receptor and their soluble ligands in humans with sepsis.

Clinically, aside from the treatment of sepsis, Dr. Gold is extremely interested in new protocols for the management of alcohol withdrawal and delirium Tremens in the ICU.
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