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Colon Cancer – KRAS and BRAF genes

Test Description

KRAS and BRAF gene mutations are detected by a combination high-resolution melting curve analysis and DNA sequencing. The assays cover known substitutions of KRAS codons 12 and 13, and BRAF codon 600. The estimated sensitivity is 10% mutant allele.

Note: MSI testing is also available for colon cancer. For information see OHSU Molecular Diagnostics Center.

How To Order This Test

To order KRAS and BRAF mutation screening, send the following items to Dr. Corless at the address below.

  1. Completed Test Requisition Form (including patient’s billing information).
  2. A paraffin block or 15 unstained slides (uncharged slides preferred) representative of the tumor.
  3. A copy of the original pathology report.

Shipping address:

Knight Diagnostic Laboratory
2525 SW 3rd Ave.
Ste. 350
Portland, OR 97201
Ph: 503-494-5400

Shipping Information: Blocks and slides may be shipped at room temperature.

CPT Codes

  CPT Code
Lysis of Cells, Paraffin 83907
DNA extraction 83890
Enzymatic digestion 83892
PCR (per exon) 83898
DNA sequencing 83904
*Professional Fee 83912

*Note: The professional fee is only for molecular testing. There is no pathology consultation fee.

For additional information, contact Knight Diagnostic Laboratory Services Center at 503-494-5400.

Links: Back to Knight Diagnostic PTRL, Research Tests Available, GIST Test Descriptions, GIST Background Information