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Research activities in the Department of Pathology span the full breadth of basic, translational and clinical sciences. Ongoing projects can be divided into the following different areas:

Dr. Marjorie Grafe is studying CNS pathology in models of brain injury in rodents. Dr. Randy Woltjer is examining the effects of neurodegenerative diseases and myopathies in humans and in rodent models.

Hematologic Malignancies
Dr. Guang Fan is investigating the predictive and prognostic impacts of oncogenic mutations in cases of AML and pre-B ALL. Dr. Katalin Kemelen is doing similar studies in myelodysplastic studies, while Dr. Rita Braziel is overseeing marker studies in clinical trials of lymphoma. Dr. Marc Loriaux has developed a novel screening method for assessing drug sensitivity in newly diagnosed cases of AML. Dr. Tony Bakke is developing new flow cytometric assays for minimal residual disease.

Solid Tumors
Dr. Megan Troxell is studying PI3 kinase mutations in pre-malignant proliferations of the breast. Dr. Christopher Corless has developed mass spectroscopy-based panels that are used for oncogene mutation screening across a variety of solid tumors and hematologic malignancies. Drs. Terry Morgan and Jody Hooper are studying novel markers for the diagnosis of HPV-related lesions of the cervix and oropharynx, and Dr. Atiya Mansoor is examining clinicopathologic correlations in sarcomas.

Molecular Diagnostics
Dr. Richard Press is developing novel assays to a number of different infectious disease agents, as well as tests for minimal residual disease testing in hematologic tumors. Dr. Chris Corless is pursuing applications of massively parallel sequencing in translational and clinical studies.

Placenta and Fetal Growth
Dr. Terry Morgan is investigating the affects of altered blood flow on the development and function of the placenta. Decreased blood flow not only predisposes to pre-eclampsia, but results in reduced fetal size and a life-time increased risk for hypertension after birth.

Other Research Activities
Drs. Megan Troxell, Jody Hooper and Atiya Mansoor are studying a number of novel immunohistochemical markers for use in diagnostic pathology. Dr. Lynn Boshkov has ongoing studies of transfusion-related acute lung injury. Dr. Tony Bakke is working on assays to differentiate autoimmune disease flares from sepsis. Dr. Ken Gatter is studying legal issues related to property rights to human tissue samples, and the use of human tissue in research.

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